Psat06G0064000-T1

Query:    1 MPTNGSIDRPNTNLVMVAVDKDKNSGYAFRWTTNNIDNPIIIAVHVKPKDIPHQEGQDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYT----KNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQN------GVASCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTNKSLESIELSGRGQRSSFN-HTSSLNENESSRLHKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEE-RTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHA 696
            MP++GS ++P TNLVMVAVDKDKNSG+AFRW TNNIDNPIIIAVHVK KDIPHQ      G NVFPPDEEDVANVF+PLREMC+D VVKMKEA+I+D+DIARGILEYAKRN +Q I+VGA SS+T    KNVLSRSLNMR+IS+KFKG+DD+ T +IKSAPDYSSV+V++K K+V++R AI+   N      G +SCKSEN LR+ TF R GSTNS +SG+S LH+ LK  LS+++SLE I++S RGQRS FN  ++S +EN+SS  HKY  +D  K +  SS AS+SQ LG MEAEMK L+LKL+QTMEMYNSACKEAI A+NKA EIN+WKLEE RTVEEVMMS+EAALAMAE EK KA AA K  DEAMKMAEKETQ+RL  ERKA +EIEE+D+ALNV+ R D+RYR+YTL++IE+AT+NFSLSMKIGEGGYGPVFKG L HTHVAIKILRPDA QGRKQFLQEVEVLCNIRHPNMVLLLGACQ+YGCLVYEYMDNGSLEDRLLRK NSPPIPW+KRFEI YEI TALLFLHQTKPE+IVHRDLKPANVLLDKNFVSKISDVGL+RLVPP VADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSD+YSLGIM LQIITA+PPMGLSHHVK++IE GNF DMLDP++TDWP E+ L FAKLALSCAELSKKDRPDLA +VIPEL+R +++G K Q   QNLSH 
Sbjct:    1 MPSHGS-NKPPTNLVMVAVDKDKNSGHAFRWITNNIDNPIIIAVHVKHKDIPHQ------GTNVFPPDEEDVANVFNPLREMCDDRVVKMKEAVIDDSDIARGILEYAKRNRIQTIIVGASSSFTSTLTKNVLSRSLNMRSISRKFKGYDDIPTTLIKSAPDYSSVFVVSKGKIVDTRSAISTSGNVVAQSHGFSSCKSENALRTQTF-RSGSTNS-RSGRSQLHEPLKF-LSSSQSLEVIDISNRGQRSPFNGDSTSSSENDSSGSHKYASLDATKQDWDSSLASDSQSLGSMEAEMKTLKLKLKQTMEMYNSACKEAITAQNKAKEINQWKLEEARTVEEVMMSKEAALAMAEEEKEKAKAAFKAADEAMKMAEKETQRRLQLERKAMKEIEEKDRALNVLTRNDIRYRKYTLEDIEHATQNFSLSMKIGEGGYGPVFKGILDHTHVAIKILRPDASQGRKQFLQEVEVLCNIRHPNMVLLLGACQEYGCLVYEYMDNGSLEDRLLRKQNSPPIPWRKRFEIAYEIVTALLFLHQTKPEAIVHRDLKPANVLLDKNFVSKISDVGLARLVPPSVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDVYSLGIMLLQIITAKPPMGLSHHVKRSIEIGNFSDMLDPLITDWPIEETLAFAKLALSCAELSKKDRPDLATLVIPELNRLRNVGTKSQKSYQNLSHV 698          

Query:    5 GSIDRPNTNLVMVAVDKDKNSGYAFRWTTNNIDNPIIIAVHVKPKDIPHQEG-QDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPL------QNGVASCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTN-------KSLESIELSGRGQRSS-FNHTSSLNENESSRLHKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERTVEEV-MMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHAPRPPTCPP 704
            G I++P+ NLVMVAV K KNSG+AFRWTTNNIDNPIIIAVHVK K  PH+      EG NVFPPDE+D+ANVF PLR+MCN+ VVK+KEAII DTDI+RGIL+YAKRN++Q I+VGAP+ Y KNVLSRSLNMRTISKKF+G DD+ATA++KSAPDYSSVYVI+K+K+VESRPAI PL       +G+A CKSEND  S  ++RG STNS +SG+S +H+ +KS  S N       +SLESI+LS R QR+   +H SSLNEN SS  +K+G ++  KLER SS  S+SQ++G+MEAEMKELRLKLRQTM MY SACKEAI A+NKANEI +WK+EE  + E  +MS+EAALA+AE EKAKA AA+K  DEAM++AEKE Q+R+  E+ A+++IEERDQALNV+AR D+RYRQYTLDEIE AT+NFSLSMKIGEGGYGPVFKGQL HT+VAIKILRPDA+QGRKQFLQEVEVLCNIRHPNMVLLLGACQ+YGCLVYEYMDNGSLEDRLLRK N+PPIPW+KRFEI YEIATALLFLHQTKPE+IVHRDLKPAN+LLDKNFVSKISDVGL+RLVPP VADSVTQYHMT AAGTLCYIDPEYQ TGKLTTKSDIYSLGIMFLQIITA+PPMGLSHHVK+AIEN NF DMLDP VTDWP ++AL FAK++L CAELSKKDRPDLAL VIPEL+R KD GC LQN+Q N SH P  P  PP
Sbjct:    4 GGINKPHINLVMVAVGKHKNSGHAFRWTTNNIDNPIIIAVHVKHKGTPHRSYVMFAEGTNVFPPDEKDIANVFSPLRQMCNEKVVKLKEAIIIDTDISRGILDYAKRNHIQTIIVGAPTGYKKNVLSRSLNMRTISKKFRGQDDLATAIMKSAPDYSSVYVISKDKVVESRPAIVPLGTVVAQSHGIAPCKSENDKWSQLYRRG-STNS-RSGRSSIHEFIKSFSSNNNNNNHNNESLESIDLSSRSQRTPPLSHNSSLNENGSSGSNKFGSLNVAKLERNSSLQSDSQLVGEMEAEMKELRLKLRQTMTMYKSACKEAISAQNKANEITQWKMEEERMVEEVIMSKEAALALAEKEKAKAKAAIKAADEAMRIAEKEAQRRMQVEKTAKKDIEERDQALNVLARKDIRYRQYTLDEIEKATQNFSLSMKIGEGGYGPVFKGQLDHTNVAIKILRPDANQGRKQFLQEVEVLCNIRHPNMVLLLGACQEYGCLVYEYMDNGSLEDRLLRKRNTPPIPWRKRFEIAYEIATALLFLHQTKPEAIVHRDLKPANILLDKNFVSKISDVGLARLVPPSVADSVTQYHMTEAAGTLCYIDPEYQNTGKLTTKSDIYSLGIMFLQIITAKPPMGLSHHVKRAIENENFFDMLDPDVTDWPVDEALAFAKISLRCAELSKKDRPDLALEVIPELNRLKDFGCDLQNYQHNQSH-PSGPLTPP 716          

Query:    5 GSIDRPNTNLVMVAVDKDKNSGYAFRWTTNNIDNPIIIAVHVKPKDIPHQEGQDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPL------QNGVASCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTN-------KSLESIELSGRGQRSS-FNHTSSLNENESSRLHKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERTVEEV-MMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHAPRPPTCPP 704
            G I++P+ NLVMVAV K KNSG+AFRWTTNNIDNPIIIAVHVK K  PHQ      G NVFPPDE+D+ANVF PLR+MCN+ VVK+KEAII DTDI+RGIL+YAKRN++Q I+VGAP+ Y KN  S  ++     K+ KG DD+ATA++KSAPDYSSVYVI+K+K+VESRPAI PL       +G+A CKSEND  S  ++RG STNS +SG+S +H+ +KS  S N       +SLESI+LS R QR+   +H SSLNEN SS  +K+G ++  KLER SS  S+SQ++G+MEAEMKELRLKLRQTM MY SACKEAI A+NKANEI +WK+EE  + E  +MS+EAALA+AE EKAKA AA+K  DEAM++AEKE Q+R+  E+ A+++IEERDQALNV+AR D+RYRQYTLDEIE AT+NFSLSMKIGEGGYGPVFKGQL HT+VAIKILRPDA+QGRKQFLQEVEVLCNIRHPNMVLLLGACQ+YGCLVYEYMDNGSLEDRLLRK N+PPIPW+KRFEI YEIATALLFLHQTKPE+IVHRDLKPAN+LLDKNFVSKISDVGL+RLVPP VADSVTQYHMT AAGTLCYIDPEYQ TGKLTTKSDIYSLGIMFLQIITA+PPMGLSHHVK+AIEN NF DMLDP VTDWP ++AL FAK++L CAELSKKDRPDLAL VIPEL+R KD GC LQN+Q N SH P  P  PP
Sbjct:    4 GGINKPHINLVMVAVGKHKNSGHAFRWTTNNIDNPIIIAVHVKHKGTPHQ------GTNVFPPDEKDIANVFSPLRQMCNEKVVKLKEAIIIDTDISRGILDYAKRNHIQTIIVGAPTGYKKNS-SFKVSKHEDYKQVKGQDDLATAIMKSAPDYSSVYVISKDKVVESRPAIVPLGTVVAQSHGIAPCKSENDKWSQLYRRG-STNS-RSGRSSIHEFIKSFSSNNNNNNHNNESLESIDLSSRSQRTPPLSHNSSLNENGSSGSNKFGSLNVAKLERNSSLQSDSQLVGEMEAEMKELRLKLRQTMTMYKSACKEAISAQNKANEITQWKMEEERMVEEVIMSKEAALALAEKEKAKAKAAIKAADEAMRIAEKEAQRRMQVEKTAKKDIEERDQALNVLARKDIRYRQYTLDEIEKATQNFSLSMKIGEGGYGPVFKGQLDHTNVAIKILRPDANQGRKQFLQEVEVLCNIRHPNMVLLLGACQEYGCLVYEYMDNGSLEDRLLRKRNTPPIPWRKRFEIAYEIATALLFLHQTKPEAIVHRDLKPANILLDKNFVSKISDVGLARLVPPSVADSVTQYHMTEAAGTLCYIDPEYQNTGKLTTKSDIYSLGIMFLQIITAKPPMGLSHHVKRAIENENFFDMLDPDVTDWPVDEALAFAKISLRCAELSKKDRPDLALEVIPELNRLKDFGCDLQNYQHNQSH-PSGPLTPP 708          

Query:   60 EGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYT----KNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQN------GVASCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTNKSLESIELSGRGQRSSFN-HTSSLNENESSRLHKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEE-RTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHA 696
            EG NVFPPDEEDVANVF+PLREMC+D VVKMKEA+I+D+DIARGILEYAKRN +Q I+VGA SS+T    KNVLSRSLNMR+IS+KFKG+DD+ T +IKSAPDYSSV+V++K K+V++R AI+   N      G +SCKSEN LR+ TF R GSTNS +SG+S LH+ LK  LS+++SLE I++S RGQRS FN  ++S +EN+SS  HKY  +D  K +  SS AS+SQ LG MEAEMK L+LKL+QTMEMYNSACKEAI A+NKA EIN+WKLEE RTVEEVMMS+EAALAMAE EK KA AA K  DEAMKMAEKETQ+RL  ERKA +EIEE+D+ALNV+ R D+RYR+YTL++IE+AT+NFSLSMKIGEGGYGPVFKG L HTHVAIKILRPDA QGRKQFLQEVEVLCNIRHPNMVLLLGACQ+YGCLVYEYMDNGSLEDRLLRK NSPPIPW+KRFEI YEI TALLFLHQTKPE+IVHRDLKPANVLLDKNFVSKISDVGL+RLVPP VADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSD+YSLGIM LQIITA+PPMGLSHHVK++IE GNF DMLDP++TDWP E+ L FAKLALSCAELSKKDRPDLA +VIPEL+R +++G K Q   QNLSH 
Sbjct:   11 EGTNVFPPDEEDVANVFNPLREMCDDRVVKMKEAVIDDSDIARGILEYAKRNRIQTIIVGASSSFTSTLTKNVLSRSLNMRSISRKFKGYDDIPTTLIKSAPDYSSVFVVSKGKIVDTRSAISTSGNVVAQSHGFSSCKSENALRTQTF-RSGSTNS-RSGRSQLHEPLKF-LSSSQSLEVIDISNRGQRSPFNGDSTSSSENDSSGSHKYASLDATKQDWDSSLASDSQSLGSMEAEMKTLKLKLKQTMEMYNSACKEAITAQNKAKEINQWKLEEARTVEEVMMSKEAALAMAEEEKEKAKAAFKAADEAMKMAEKETQRRLQLERKAMKEIEEKDRALNVLTRNDIRYRKYTLEDIEHATQNFSLSMKIGEGGYGPVFKGILDHTHVAIKILRPDASQGRKQFLQEVEVLCNIRHPNMVLLLGACQEYGCLVYEYMDNGSLEDRLLRKQNSPPIPWRKRFEIAYEIVTALLFLHQTKPEAIVHRDLKPANVLLDKNFVSKISDVGLARLVPPSVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDVYSLGIMLLQIITAKPPMGLSHHVKRSIEIGNFSDMLDPLITDWPIEETLAFAKLALSCAELSKKDRPDLATLVIPELNRLRNVGTKSQKSYQNLSHV 656          

Query:   90 MKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYT----KNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQN------GVASCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTNKSLESIELSGRGQRSSFN-HTSSLNENESSRLHKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEE-RTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSH 695
            MKEA+I+D+DIARGILEYAKRN +Q I+VGA SS+T    KNVLSRSLNMR+IS+KFKG+DD+ T +IKSAPDYSSV+V++K K+V++R AI+   N      G +SCKSEN LR+ TF R GSTNS +SG+S LH+ LK  LS+++SLE I++S RGQRS FN  ++S +EN+SS  HKY  +D  K +  SS AS+SQ LG MEAEMK L+LKL+QTMEMYNSACKEAI A+NKA EIN+WKLEE RTVEEVMMS+EAALAMAE EK KA AA K  DEAMKMAEKETQ+RL  ERKA +EIEE+D+ALNV+ R D+RYR+YTL++IE+AT+NFSLSMKIGEGGYGPVFKG L HTHVAIKILRPDA QGRKQFLQEVEVLCNIRHPNMVLLLGACQ+YGCLVYEYMDNGSLEDRLLRK NSPPIPW+KRFEI YEI TALLFLHQTKPE+IVHRDLKPANVLLDKNFVSKISDVGL+RLVPP VADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSD+YSLGIM LQIITA+PPMGLSHHVK++IE GNF DMLDP++TDWP E+ L FAKLALSCAELSKKDRPDLA +VIPEL+R +++G K Q   QNLSH
Sbjct:    1 MKEAVIDDSDIARGILEYAKRNRIQTIIVGASSSFTSTLTKNVLSRSLNMRSISRKFKGYDDIPTTLIKSAPDYSSVFVVSKGKIVDTRSAISTSGNVVAQSHGFSSCKSENALRTQTF-RSGSTNS-RSGRSQLHEPLKF-LSSSQSLEVIDISNRGQRSPFNGDSTSSSENDSSGSHKYASLDATKQDWDSSLASDSQSLGSMEAEMKTLKLKLKQTMEMYNSACKEAITAQNKAKEINQWKLEEARTVEEVMMSKEAALAMAEEEKEKAKAAFKAADEAMKMAEKETQRRLQLERKAMKEIEEKDRALNVLTRNDIRYRKYTLEDIEHATQNFSLSMKIGEGGYGPVFKGILDHTHVAIKILRPDASQGRKQFLQEVEVLCNIRHPNMVLLLGACQEYGCLVYEYMDNGSLEDRLLRKQNSPPIPWRKRFEIAYEIVTALLFLHQTKPEAIVHRDLKPANVLLDKNFVSKISDVGLARLVPPSVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDVYSLGIMLLQIITAKPPMGLSHHVKRSIEIGNFSDMLDPLITDWPIEETLAFAKLALSCAELSKKDRPDLATLVIPELNRLRNVGTKSQKSYQNLSH 615          

Query:   10 PNTNLVMVAVDKDKNSGYAFRWTTNNIDNPIIIAVHVKPKDIPHQEGQDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQNGVASCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTNKSLESIELSGRGQRSSFNHTSSLNENESSRLHKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERTVEEVM-MSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHAPRPPTCPPSRSP 708
            P  N+ MVAV+KDKNSGYAFRWT  +IDNP+IIAVHVK K+IPH EG      NVFPPDE+D+A+VF PLR MC+  VV +KEA+I+D+DI +GI+EYA+RN V  IVVGAP S ++N L+R+LN+R+ SKKFKGH DV+T V+KSAPDYSSVYVI+K K+V +RPAI P+ N V S K EN +R+ + +RG STN  +S +S L +  + S S  +++         QRS F+HTS  +++  S  HK+   DG K +    + S+SQ LGDMEAEM+ LRLKL+QTM+MYNS CK+ ILA+ KA EIN+WK EER  EE   + +EAAL +AE EK KA AAL+  +EA+KM EKE Q+R+ AE KARRE +E+D+ALN++   D RYR+Y++ +IE AT+ FS S+K+GEGGYGPVF+GQL HT VAIKIL PDA  GR+QF QEVE+LC+IRHPNMVLLLGAC +YGCLVYEY++NGSLEDRLL K++SPPIPW KRFEI  EIATALLFLHQTKPE IVHRDLKPAN+LLDKNFVSKISDVGL+RLVPP VADSVTQYH+T+AAGT CYIDPEYQQTGKLT KSDIYSLGIM LQIITA+PPMGL+HHV+ AIE   F +MLD +++D P E+AL F KL+LSC ELSKKDRPDLA VV+PEL+R +D G   QN     SH P  PT  P+RSP
Sbjct:   12 PPLNVTMVAVEKDKNSGYAFRWTIEHIDNPVIIAVHVKHKNIPHHEG-----TNVFPPDEDDIAHVFKPLRHMCHGKVVMLKEAVIDDSDIVKGIVEYAQRNRVNTIVVGAPHS-SRNTLARTLNLRSGSKKFKGHHDVSTGVMKSAPDYSSVYVISKGKIVGARPAIRPMINVVPSQK-ENGVRTYSHRRG-STNG-RSERSALLEMPRCS-SAGQTM--------NQRSLFSHTSGYSDSSGS--HKFESADGNKQDCDLGSTSDSQFLGDMEAEMRMLRLKLKQTMDMYNSTCKDVILAQTKAKEINQWK-EERIAEEATKLPKEAALELAEKEKVKAQAALEAYEEAIKMVEKEAQRRIQAEVKARREAQEKDRALNLLIINDTRYRKYSIKDIEEATQKFSPSLKVGEGGYGPVFRGQLDHTPVAIKILNPDASHGRRQFQQEVEILCSIRHPNMVLLLGACPEYGCLVYEYLENGSLEDRLLMKNDSPPIPWWKRFEIAAEIATALLFLHQTKPEPIVHRDLKPANILLDKNFVSKISDVGLARLVPPSVADSVTQYHLTAAAGTFCYIDPEYQQTGKLTKKSDIYSLGIMLLQIITAKPPMGLAHHVRMAIEKETFSEMLDIMISDVPLEEALAFVKLSLSCTELSKKDRPDLATVVVPELNRLRDFGLAFQNR----SHPPHLPT--PTRSP 684          

Query:   10 PNTNLVMVAVDKDKNSGYAFRWTTNNIDNPIIIAVHVKPKDIPHQEGQDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQNGVASCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTNKSLESIELSGRGQRSSFNHTSSLNENESSRLHKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERTVEEVM-MSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHAPRPPTCPPSRSP 708
            P  N+ MVAV+KDKNSGYAFRWT  +IDNP+IIAVHVK K+IPH EG      NVFPPDE+D+A+VF PLR MC+  VV +KEA+I+D+DI +GI+EYA+RN V  IVVGAP S ++N L+R+LN+R+ SKKFKGH DV+T V+KSAPDYSSVYVI+K K+V +RPAI P+ N V S K EN +R+ + +RG STN  +S +S L +  + S S  +++         QRS F+HTS  +++  S  HK+   DG K +    + S+SQ LGDMEAEM+ LRLKL+QTM+MYNS CK+ ILA+ KA EIN+WK EER  EE   + +EAAL +AE EK KA AAL+  +EA+KM EKE Q+R+ AE KARRE +E+D+ALN++   D RYR+Y++ +IE AT+ FS S+K+GEGGYGPVF+GQL HT VAIKIL PDA  GR+QF QEVE+LC+IRHPNMVLLLGAC +YGCLVYEY++NGSLEDRLL K++SPPIPW KRFEI  EIATALLFLHQTKPE IVHRDLKPAN+LLDKNFVSKISDVGL+RLVPP VADSVTQYH+T+AAGT CYIDPEYQQTGKLT KSDIYSLGIM LQIITA+PPMGL+HHV+ AIE   F +MLD +++D P E+AL F KL+LSC ELSKKDRPDLA VV+PEL+R +D G   QN     SH P  PT  P+RSP
Sbjct:   12 PPLNVTMVAVEKDKNSGYAFRWTIEHIDNPVIIAVHVKHKNIPHHEG-----TNVFPPDEDDIAHVFKPLRHMCHGKVVMLKEAVIDDSDIVKGIVEYAQRNRVNTIVVGAPHS-SRNTLARTLNLRSGSKKFKGHHDVSTGVMKSAPDYSSVYVISKGKIVGARPAIRPMINVVPSQK-ENGVRTYSHRRG-STNG-RSERSALLEMPRCS-SAGQTM--------NQRSLFSHTSGYSDSSGS--HKFESADGNKQDCDLGSTSDSQFLGDMEAEMRMLRLKLKQTMDMYNSTCKDVILAQTKAKEINQWK-EERIAEEATKLPKEAALELAEKEKVKAQAALEAYEEAIKMVEKEAQRRIQAEVKARREAQEKDRALNLLIINDTRYRKYSIKDIEEATQKFSPSLKVGEGGYGPVFRGQLDHTPVAIKILNPDASHGRRQFQQEVEILCSIRHPNMVLLLGACPEYGCLVYEYLENGSLEDRLLMKNDSPPIPWWKRFEIAAEIATALLFLHQTKPEPIVHRDLKPANILLDKNFVSKISDVGLARLVPPSVADSVTQYHLTAAAGTFCYIDPEYQQTGKLTKKSDIYSLGIMLLQIITAKPPMGLAHHVRMAIEKETFSEMLDIMISDVPLEEALAFVKLSLSCTELSKKDRPDLATVVVPELNRLRDFGLAFQNR----SHPPHLPT--PTRSP 684          

Query:   13 NLVMVAVDKDKNSGYAFRWTTNNIDNPIIIAVHVKPKDIPHQEGQDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLS-------RSLNMRTISKKFKGHDD---VATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQNGVASCK-------------SENDLRSNT-FKRGGSTNSSKSGKSPLHDKLKSSLSTN-KSLESIELS-GRGQRSSFNHTSSLNENESSRLHKYGLVD----GQKLERGS----------STASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERT-VEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQ-QNLSHA 696
            N+ MVAVD DKNSGYAF W T++I+N IIIAVHVK K+IPHQ      G NV  PDE+D ANVF  +R +CN NVVK+KEA+++D+DI RGILE+A+RN++ +IVVGAPS+  KN L+       RS  +RT +KK K H +   VA A+IK APD+ SVYVI+K K+V  RPA +PL N VA  K             SEN +  N+   +     S++      + + +S +ST+ +S+ S +L+  RGQR S    S+ +EN SS   KYG +D       L+ GS          S AS+SQ  GD+E EMK+LRLKL+QTM+MY+SACK+AI A+NKA EIN WK+E R   ++V +S E ALAMAE EKAK   AL+  ++AMKMAEKE  +RL AE+ A+RE +E+D AL  +A  D R R+YT+++IE AT+ FS S+KIGEGGYGPVFKGQL HT VAIK+L P+A QGRKQF QEVEVL  IRHPNMVLLLGAC +YGCLVYEYM+NGSLEDRLL K+NSPPIPW KRFEI  EIATALLFLHQTKPE +VHRDLKPAN+LLD+NFVSKI DVGL+RLVPP VADSVTQYHMT+AAGT CYIDPEYQQTGKLTTKSDIYSLGI+ LQIITA+PPMG++HHV +AI+NG+F DMLDPVVTDWP E+AL FAKLAL CAELSKKDRP+LALVV+PEL+R +D G   Q +Q +N SH+
Sbjct:   16 NITMVAVDSDKNSGYAFHWATHHIENSIIIAVHVKHKNIPHQ------GTNVCRPDEDDEANVFSQIRPLCNPNVVKLKEAVVDDSDITRGILEFAQRNHIHSIVVGAPSTKNKNALTGVGKLTARSFTIRTGTKKHKEHHNPQKVAEAIIKEAPDHISVYVISKRKLVAVRPATSPLVNVVAPPKQPPVQPLQPNDYESENGVSYNSNMTQTPRVRSTRERAERKNARERSRISTSTQSMGSFDLTINRGQRLS----STSDENNSSGSLKYGSMDVTNSSGSLKYGSTDVTKHNMDLSIASDSQPSGDVEVEMKKLRLKLKQTMDMYSSACKDAISAQNKAEEINNWKMERRQRFKDVRLSEETALAMAEKEKAKVKDALEAAEKAMKMAEKEAHRRLQAEKMAKREAKEKDWALTALASKDFRCREYTIEDIEKATEKFSPSLKIGEGGYGPVFKGQLDHTPVAIKLLNPEASQGRKQFQQEVEVLSTIRHPNMVLLLGACPEYGCLVYEYMNNGSLEDRLLMKNNSPPIPWPKRFEIASEIATALLFLHQTKPEPLVHRDLKPANILLDRNFVSKIGDVGLARLVPPSVADSVTQYHMTTAAGTFCYIDPEYQQTGKLTTKSDIYSLGIVLLQIITAKPPMGIAHHVNRAIDNGSFSDMLDPVVTDWPVEEALAFAKLALKCAELSKKDRPNLALVVVPELNRLRDFGYTSQTNQIKNRSHS 731          

Query:   13 NLVMVAVDKDKNSGYAFRWTTNNIDNPIIIAVHVKPKDIPHQEGQDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDD---VATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQNGVA---------SCKSENDLRSNT-FKRGGSTNSSKSGKSPLHDKLKSSLSTN-KSLESIELS-GRGQRSSFNHTSSLNENESSRLHKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERT-VEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQ-QNLSHAPRPPT 701
            N+ MVAVD DKNSGYAF W T++I+N IIIAVHVK K+IPHQ      G NV  PDE+D ANVF  +R +CN N+VK+KEA+++D+DI RGILE+A+RN++  IVVGAPS+  KN L+    +   ++K K H +   VA A+IK APDY SVYVI+K K+V  RPA +PL N VA           +SEN +  N+   +     S++      H + +  +ST+ +S+ S +L+  R QR     +SS +EN SS   KYG  D  K +   S AS+SQ  GD+E EMK+LRLKL+QTM+MY+SACK+AI A+NKA EIN WK+E R   ++V +S E ALAMAE EKAK  AAL+  ++AMKMAEKE ++RL AE+ A+R+ +E+D AL  +A  + R R+YT+++IE AT+ FS S+KIGEGGYGPVFKGQL HT VAIK+L P+A QGRKQF QEVEVL  IRHPNMVLLLGAC +YGCLVYEYM+ GSLEDRLL K+NSPPIPW KRFEI  EIATALLFLHQTKPE +VHRDLKPAN+LLD+NFVSKISDVGL+RLVPP VADSVTQY+MT+AAGT CYIDPEYQQTGKLTTKSDIYS GI+ LQIITA+PPMG++HHVK+AI+NG+F DMLDPVVTDWP E+AL FAKLAL CAELSKKDRP+LALVV+PEL+R +D G   QN+Q +N SH+PRPPT
Sbjct:   14 NITMVAVDSDKNSGYAFHWATHHIENSIIIAVHVKHKNIPHQ------GTNVCRPDEDDEANVFSQIRPLCNPNIVKLKEAVVDDSDITRGILEFAQRNHIHCIVVGAPSTKNKNSLTSVGKL--TARKHKEHQNPQKVAEAIIKEAPDYISVYVISKRKLVAVRPATSPLVNVVAPPVQPLQPNDYESENGVSYNSNMTQTPRVRSTRERTERKHARERPRISTSTQSMGSFDLTINREQRL----SSSSDENNSSGSLKYGSTDVIKHDMDLSIASDSQSSGDVEVEMKKLRLKLKQTMDMYSSACKDAISAQNKAEEINLWKMERRQRFKDVRLSEETALAMAEKEKAKVKAALEAAEKAMKMAEKEARRRLQAEKMAKRDAKEKDWALTALASKEFRCREYTIEDIEKATEKFSPSLKIGEGGYGPVFKGQLDHTSVAIKLLNPEASQGRKQFQQEVEVLSTIRHPNMVLLLGACPEYGCLVYEYMNKGSLEDRLLMKNNSPPIPWPKRFEIASEIATALLFLHQTKPEPLVHRDLKPANILLDRNFVSKISDVGLARLVPPSVADSVTQYYMTAAAGTFCYIDPEYQQTGKLTTKSDIYSFGIVLLQIITAKPPMGIAHHVKRAIDNGSFSDMLDPVVTDWPVEEALAFAKLALKCAELSKKDRPNLALVVVPELNRLRDFGYTSQNNQIKNRSHSPRPPT 707          

Query:   60 EGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQNGVASCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTNKSLESIELSGRGQRSSFNHTSSLNENESSRLHKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERTVEEVM-MSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHAPRPPTCPPSRSP 708
            EG NVFPPDE+D+A+VF PLR MC+  VV +KEA+I+D+DI +GI+EYA+RN V  IVVGAP S ++N L+R+LN+R+ SKKFKGH DV+T V+KSAPDYSSVYVI+K K+V +RPAI P+ N V S K EN +R+ + +RG STN  +S +S L +  + S S  +++         QRS F+HTS  +++  S  HK+   DG K +    + S+SQ LGDMEAEM+ LRLKL+QTM+MYNS CK+ ILA+ KA EIN+WK EER  EE   + +EAAL +AE EK KA AAL+  +EA+KM EKE Q+R+ AE KARRE +E+D+ALN++   D RYR+Y++ +IE AT+ FS S+K+GEGGYGPVF+GQL HT VAIKIL PDA  GR+QF QEVE+LC+IRHPNMVLLLGAC +YGCLVYEY++NGSLEDRLL K++SPPIPW KRFEI  EIATALLFLHQTKPE IVHRDLKPAN+LLDKNFVSKISDVGL+RLVPP VADSVTQYH+T+AAGT CYIDPEYQQTGKLT KSDIYSLGIM LQIITA+PPMGL+HHV+ AIE   F +MLD +++D P E+AL F KL+LSC ELSKKDRPDLA VV+PEL+R +D G   QN     SH P  PT  P+RSP
Sbjct:   30 EGTNVFPPDEDDIAHVFKPLRHMCHGKVVMLKEAVIDDSDIVKGIVEYAQRNRVNTIVVGAPHS-SRNTLARTLNLRSGSKKFKGHHDVSTGVMKSAPDYSSVYVISKGKIVGARPAIRPMINVVPSQK-ENGVRTYSHRRG-STNG-RSERSALLEMPRCS-SAGQTM--------NQRSLFSHTSGYSDSSGS--HKFESADGNKQDCDLGSTSDSQFLGDMEAEMRMLRLKLKQTMDMYNSTCKDVILAQTKAKEINQWK-EERIAEEATKLPKEAALELAEKEKVKAQAALEAYEEAIKMVEKEAQRRIQAEVKARREAQEKDRALNLLIINDTRYRKYSIKDIEEATQKFSPSLKVGEGGYGPVFRGQLDHTPVAIKILNPDASHGRRQFQQEVEILCSIRHPNMVLLLGACPEYGCLVYEYLENGSLEDRLLMKNDSPPIPWWKRFEIAAEIATALLFLHQTKPEPIVHRDLKPANILLDKNFVSKISDVGLARLVPPSVADSVTQYHLTAAAGTFCYIDPEYQQTGKLTKKSDIYSLGIMLLQIITAKPPMGLAHHVRMAIEKETFSEMLDIMISDVPLEEALAFVKLSLSCTELSKKDRPDLATVVVPELNRLRDFGLAFQNR----SHPPHLPT--PTRSP 657          

Query:  282 DMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERT-VEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPG-VADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIE-NGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHAPRPPT---CP 703
            ++  E+++LR +LR   EMY  A  E   A  K  E+N+ +LEE   +EE+ +    A  +AE EK     A +  +   + AE+E  +R  AERK+ R+ +E+++    +    ++Y+ +  +EI  AT +FS  +KIG G YG V+K  L HT   +K+L+   +Q  KQF QE+E+L  IRHP++VLLLGAC + G LVYEYM+NGSLEDRL + +NSPP+PW +RF I +E+A AL+FLH++KP+ I+HRDLKPAN+LLD NFVSK+ DVGLS +V    ++   T Y  TS  GTLCYIDPEYQ+TG++++KSDIYS G++ LQ++TA+P + L+H V+ A++ N  F+ +LD    +WP E+    A LAL C EL  KDRPDL   ++P L   K +  K +N    +S   +PPT   CP
Sbjct:  348 NLNFEVEKLRAELRHVQEMYAVAQTETFDASRKLGELNQRRLEEAIKLEELKLKEYEARELAEKEKQNFEKARRDAESMRERAEREIAQRREAERKSARDTKEKEKLEGTLGSPQLQYQHFAWEEIMAATSSFSEELKIGMGAYGAVYKCNLHHTTAVVKVLQSAENQLSKQFQQELEILSKIRHPHLVLLLGACPEQGALVYEYMENGSLEDRLFQVNNSPPLPWFERFRIAWEVAAALVFLHKSKPKPIIHRDLKPANILLDHNFVSKVGDVGLSTMVQVDPLSTKFTIYKQTSPVGTLCYIDPEYQRTGRISSKSDIYSFGMILLQLLTAKPAIALTHFVESAMDSNDEFLKILDQKAGNWPIEETRELAALALCCTELRGKDRPDLKDQILPALENLKKVAEKARNSFSGVS--TQPPTHFICP 773          

Query:  282 DMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEE-RTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAI-ENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHAPRPPTCPPS 705
            ++  E+++LR +L+   EMY  A  E + A  K  E+N+ + EE   + E+    E A   A  EK +   A+K  ++  ++  KE   R  AE KA R+  E+D+    +    V+Y+ YT +EI  AT +F+ ++KIG G YG V+K  L HT  A+K+L     Q  KQF QE+E+L  IRHP++VLLLGAC + GCLVYEYMDNGSL+DRL+  +++PPIPW +RF I  E+A+AL+FLH++KP  I+HRDLKP N+LLD NFVSK+ DVGLS +V      S T +  TS  GTLCYIDPEYQ+TG ++ KSD+YSLG++ LQ+ITA+P + ++H V++AI ++  F+ +LD     WP  D    A L L C E+ ++DRPDL   +IP L R + +  K QN         R P+ PPS
Sbjct:  358 NLNFEIEKLRAELKHVQEMYAMAQTETVGASKKLTELNQRRFEESEKLVELKEKEEVAKDTASKEKQRYEEAMKEAEKVKELMMKEALHRREAEFKAERDAREKDKLQASLVSPGVQYQHYTWEEIAAATSDFAENLKIGIGAYGSVYKCNLHHTTGAVKVLHAGETQLSKQFDQELEILSKIRHPHLVLLLGACPERGCLVYEYMDNGSLDDRLMLVNDTPPIPWFERFRIALEVASALVFLHKSKPRPIIHRDLKPGNILLDHNFVSKLGDVGLSTMVNQDDVSSRTIFKQTSPVGTLCYIDPEYQRTGIISPKSDVYSLGVVILQLITAKPAIAITHMVEEAIGDDAEFMAILDKKAGSWPISDTRELAALGLCCTEMRRRDRPDLKDQIIPALERLRKVADKAQNLLS------RTPSGPPS 777          

Query:   14 LVMVAV--DKDKNSGYAFRWTTNNI---DNPIIIAVHVKPKDIPHQEGQDRE-GVNVFPPD-EEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQNGVASCKSENDLRSNTFKRGGSTNSSKSGK---SPLHDKLKSSLSTNKSLESIELSGRGQR---SSFNHTSSLNENESSRLHKYGLVD-----------------GQKLERGSS-------TASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERT-VEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKA---RREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKH------NSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAI--ENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQN--------HQQNLSHAPRPPTCPPSR 706
            +V VA+  +  K  G   RW        ++ +   +HV+P+D        ++   +V+  D +     +  P R+M     V++   ++   DIA  I +  + + +  +V+GA SS    + S  L    +S +          +  + P + SV+VI+K K++  R +    +  +A  +SE+   S++    G+ +S+ S +   +PL  +   +L+T        +  +         N   SL+ +ES  L++ G                      ++E  SS       T+S+SQI  D E E  +L+++LR    MY  A  E I A  K  ++N+ + EE T ++ + +  E A  + E+E+ +   A    +   +  E+ET++RL AE +A   R+E +  + AL        +Y ++  +EI  AT +FS  +KIG GGYG V++  L HT VA+K+L  D     KQF QE+E+L  IRHP+++LLLGAC + G LVYEYM NGSLE+RL+++         PP+ W +RF I +EIA+AL FLH  +P  IVHRDLKPAN+LLD+N VSKI DVGLS++V    + + T ++ T   GT  YIDPEYQ+TG +T +SDIY+ GI+ LQ++TAR  MGL+H ++KA+  + G F ++LD    DWP ++A     + L CAE+ K+DRPDL   ++P L R K++    +N        H  N   AP    CP ++
Sbjct:    7 IVAVAIKGNNSKTKG-VVRWALQEFASQEHVVFKLLHVQPRDSNSVSTTRKDLTTSVYKKDVDRKTREMLLPSRDMFVHREVQLDIMVLESDDIADAISKAVQDHGISELVIGASSSI---IFSWKLKRSNLSSR----------IADATPRFCSVHVISKGKLLNVRKSDMDTETSIADDRSESRFSSDS--HSGTVSSTSSHQFSSTPLLFQRIQALTTVNQKVGTNIGKQNNEPHHHHHNRAGSLDVDESKLLNQKGFYRTSSSGIGYGGSDISSWRSSQMEEASSSSTYSDPTSSSSQIHKDFELE--KLKIELRHIKGMYAVAQSEVIDASKKMQDLNQRRSEEATRLKNLTIREEEADEVVEMERERQEDAENEAELVRECIERETEERLEAEARAEEVRKEKQRLEDALEGGPLQRQQYMKFEWEEIVEATSSFSDELKIGVGGYGSVYRCNLHHTTVAVKVLHSDKSSLTKQFHQELEILSKIRHPHLLLLLGACPERGSLVYEYMHNGSLEERLMKRRPNVDTPQPPPLRWFERFRIAWEIASALYFLHTNEPRPIVHRDLKPANILLDRNNVSKIGDVGLSKMVNLDPSHASTVFNETGPVGTFFYIDPEYQRTGVVTPESDIYAFGIILLQLVTARSAMGLAHSIEKALRDQTGKFTEILDKTAGDWPVKEAKEMVMIGLRCAEMRKRDRPDLGKEILPVLERLKEVASIARNMFADNLIDHHHN---APTHFYCPITK 735          

Query:  290 LRLKLRQTMEMYNSACKEAILAKNKANEINKWKL-EERTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLG-CKLQNHQQNLSHAPRPPTCP 703
            L+ +L+ T+  Y  AC+E    +NK   ++   L E + V   +   E     A +EK + + A+K V+ A  +  +E  +R  AE  A R   E+ + ++ +  TD RYR+YT++EI  AT+ FS    IGEGGYG V++  L  T  A+K++R D  + +++FL+EVEVL  +RHP++VLLLGAC + GCLVYEY++NGSLE+ +  + N PP+PW  RF + +E+A  L FLH +KPE IVHRDLKP N+LL++N+VSKI+DVGL++LV     D+VT Y  +  AGTL YIDPEY +TG +  KSD+Y+ GI+ LQ++TAR P G+   V+ A++ G   +MLD  VTDWP  +    A++ L CAE   +DRPDL   VIP L R  +    K++    NL  AP    CP
Sbjct:  318 LKNELQSTVFKYKQACEELFSTQNKVKMLSTEYLNESKRVNNAVEKEELQRNTAALEKERYMKAVKEVETAKALLAREFCQRQIAEVNALRTYLEKKKVIDQLLGTDHRYRKYTIEEIVTATEGFSPEKVIGEGGYGKVYQCSLDSTPAAVKVVRLDTPEKKQEFLKEVEVLSQLRHPHVVLLLGACPENGCLVYEYLENGSLEEYIFHRKNKPPLPWFIRFRVIFEVACGLAFLHSSKPEPIVHRDLKPGNILLNRNYVSKIADVGLAKLVTDVAPDNVTMYRNSVLAGTLHYIDPEYHRTGTIRPKSDLYAFGIIILQLLTARNPSGIVPAVENAVKKGTLTEMLDKSVTDWPLAETEELARIGLKCAEFRCRDRPDLKSEVIPVLKRLVETANSKVKKEGSNL-RAPSHYFCP 732          

Query:  286 EMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIART-DVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPG--VADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGN---FVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHAP-RPPT---CP 703
            E+ +LR +LR   EMY  A  E + A  K NE+   K EE T+ E        +A  E EK           E  +  E+E  +R  AE KA  E +E+++          ++Y+++T +EI NAT +FS  +KIG G YG V+K  L HT  A+K+L        KQF QE+E+L  IRHP++VLLLGAC D+G LVYEYM+NGSLEDRL + ++S PIPW  R  I +E+A+AL+FLH++KP  I+HRDLKPAN+LL+ NFVSK+ DVGLS ++     ++   T Y  TS  GTLCYIDPEYQ+TG+++ KSD+Y+ G++ LQ++T +  M L++ V+ A+EN N    + +LD    +WP E+    A LAL C EL  KDRPDL   ++P L   K +  K +N   +LS AP +PP+   CP
Sbjct:  348 EISKLRAELRHAHEMYAVAQVETLDASRKLNEL---KFEELTLLE---HETKGIAKKETEKF----------EQKRREEREAAQRREAEMKATHEAKEKEKLEESSLVAPKLQYQEFTWEEIINATSSFSEDLKIGMGAYGDVYKCNLHHTIAAVKVLHSAESSLSKQFDQELEILSKIRHPHLVLLLGACPDHGALVYEYMENGSLEDRLFQVNDSQPIPWFVRLRIAWEVASALVFLHKSKPTPIIHRDLKPANILLNHNFVSKVGDVGLSTMIQAADPLSTKFTMYKQTSPVGTLCYIDPEYQRTGRISPKSDVYAFGMIILQLLTGQQAMALTYTVETAMENNNDDELIQILDEKAGNWPIEETRQLAALALQCTELRSKDRPDLEDQILPVLESLKKVADKARN---SLSAAPSQPPSHFFCP 756          

Query:    7 IDRPNTNLV----MVAVDKD-KNSGYAFRWTTNNIDNPIIIAVHVKPKDIPHQEGQ--------------DREGVNVFPPDE-EDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPA-ITPLQNGVASCK---SENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTNKSLESIELSGRGQRSSFNHTSSLNENESSRLHKYGLV------------DGQ------KLERGSSTASNS------QILGDMEAEMKELRL--KLRQTMEMYNSACK-----EAILAKNKANEINKWKLEERTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQK------RLHAER-KARREIEE-RDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVV 672
            +D P + L+     VAVDK    S     W   N     I  +HV      HQ  Q                E V VF   E E V  + D    +C    V+ ++  I    I  GI++      ++ +V+GA +        R  + R    K +     A  V + AP    ++   K  ++ +R A +   ++  AS +   S +DL   TF    S +   S +    D ++  +S   S E    SGR    S N      E++ S +     V            DG       K+ + +S A +S      + L   +AE   L    + +Q+   Y+   K     E  +AK K   I   K E+  + E + S  A  AM E + AK+   ++ +++ + +A K  QK       L  ER +A RE EE R  A     +    +  ++  EIE AT +F  ++KIGEGGYG ++ G L HT VAIK+L P++ QG  ++ QEV+VL  +RHPN++ L+GAC +   LVYEY+  GSLEDRL  K NSPP+ WQ R  I  EI  AL+FLH  K  S+VH DLKPAN+LLD N VSK+SD G   L+ P  + SV     T   GT+ Y+DPE   +G+LT KSD+YS GI+ L+++T RP + +S+ VK A++NG   D+LDP+  DWP   A   A+LAL C E   ++RPDL   V
Sbjct:   35 MDEPVSRLIDEKIFVAVDKHVAKSKSTLIWALQNTGGKKICLIHV------HQPSQMIPLMGAKFPVGAVKEEEVRVFREKEREKVHMILDDYLRICQQRGVRAEKMFIEMESIENGIVQLISELGIRKLVMGAAAD-------RHYSRRMTDLKSRK----AIFVRREAPTLCQIWFTCKGYLIHTREATMDDTESEYASPRPSISASDLL-QTFSTPESEHQHIS-RVQSTDSVQQLVSNGSSTEQ---SGRVSDGSLNTDEEERESDGSEVTGSATVMSSGHSSPSSFPDGVDDSFNVKIRKATSEAHSSKQEAFAETLRRQKAEKNALDAIRRAKQSESAYSEELKRRKDTEIAVAKEKERFIT-IKNEQEVIMEELQSAMAQKAMLESQIAKSDGTMEKLNQKLDIAVKLLQKLRDEREELQTERDRALREAEELRSHAETSTLQLPQYFTDFSFSEIEEATNHFDSTLKIGEGGYGSIYVGLLRHTQVAIKMLNPNSSQGPVEYQQEVDVLSKMRHPNIITLIGACPEGWSLVYEYLPGGSLEDRLTCKDNSPPLSWQNRVRIATEICAALVFLHSNKAHSLVHGDLKPANILLDSNLVSKLSDFGTCSLLHPNGSKSVR----TDVTGTVAYLDPEASSSGELTPKSDVYSFGIILLRLLTGRPALRISNEVKYALDNGTLNDLLDPLAGDWPFVQAEQLARLALRCCETVSENRPDLGTEV 736          

Query:  377 ARREIEE----RDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHAPRPPT---CPPSR 706
            A RE+EE    R Q L+V+      + +++  E+E+AT+NFS S+KIGEGG+G V+KG L +  VAIK+LRPD+ QG+ QF QEV +L  +RHP++V LLGAC +   LVYE++ NGSLED L+       + WQ R  I  EI +AL+FLH+ KP  +VH DLKPAN+LL  N VSK+SD G+SRL+     ++ T Y      GT  Y+DPE+  TG+LT +SD+YS GI+ L+++T +PP+G+ + V+ A+E G+   ++D  V +WP       A LAL C ELS++ RPDL+  V   +   +D      +  ++      PP+   CP S+
Sbjct:  407 AVREVEELRQKRGQMLSVL--VTAMHCEFSSSEVESATENFSNSLKIGEGGFGCVYKGILRNMTVAIKVLRPDSLQGQSQFEQEVSILSRVRHPHLVTLLGACSESSTLVYEFLPNGSLEDFLMCSDKRQTLTWQARIRIIAEICSALIFLHKNKPHPVVHGDLKPANILLGVNLVSKLSDFGISRLLIQSSTNNTTLYRTMHPVGTPLYMDPEFLSTGELTPQSDVYSFGIVVLRLLTGKPPVGIKNIVEDAMEKGDLNSVIDTSVGEWPHLHIEQLAYLALRCTELSRRCRPDLSGEVWAIVEAIRDAALSSPSSSRSAQDQNSPPSYFICPISQ 741          

Query:  401 YTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKD 681
            Y+  EI  AT  F  S K+GEG YG V+KG L H  VA+K+L         +F + VE+L  +RHPN+V L+GAC +   L+Y+Y+ NGSLED    ++N P + W+ R  I  EI +ALLFLH   P  I+H +LKP+ +LLD N V+KI+D G+S+L+P    D               ++DP Y  + ++T +SDIY+ GI+ LQ++T RP  G+   VK A+EN N   +LD    DWP       A +A+ C + +  +RPDLA+V+     RF D
Sbjct:  448 YSFMEINEATNEFDPSWKLGEGKYGSVYKGNLQHLQVAVKMLPSYGSLNHFEFERRVEILSRVRHPNLVTLMGACPESRSLIYQYIPNGSLEDCFSSENNVPALSWESRIRIASEICSALLFLHSNIP-CIIHGNLKPSKILLDSNLVTKINDYGISQLIPIDGLDKSDP-----------HVDPHYFVSREMTLESDIYAFGIILLQLLTRRPVSGILRDVKCALENDNISAVLDNSAGDWPVARGKKLANVAIRCCKKNPMNRPDLAVVL-----RFID 711          

Query:  324 EERTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEE-RDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRL------VPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDL---ALVVIPELSR 678
            + +T EEV   R+  +   E+   K  A    V +   +   +  K  H    A +++ E RDQ+ ++I         ++  ++E AT++F  + ++G+  YG  +KG + +  V IK+        +K F QEV +L   RHPN++  +G C +   LVYE++ NG+LEDR++  +NS P+ W  R +I  EI  ALLFLH  K  ++VH DL+P N+L+D N+ SKI + G+S L       PP +               L Y+DPE+  TG+LTT SD+YSLG++ L+++T  PP+ LS  V +A+ + +   ++D    DWP  +A   A + LSC  +++K RPDL     +VI  L+R
Sbjct:   81 DRKTYEEV---RKVHILEEEIVTLKHQADTYLVQKEKAVTAYDQLK--HERDNAVQQVNELRDQSTHIIL-------DFSRKDMEQATEHFKNAREVGDTEYGHTYKGMIHNMKVLIKL-----SSSQKLFQQEVSILRQWRHPNIITFIGVCSEVSALVYEWLPNGNLEDRIICTNNSAPLSWYNRTQIIGEICCALLFLHSNKSTALVHGDLRPCNILIDANYRSKICNFGMSNLFLQLGTFPPNL------------TARLPYMDPEFNTTGELTTLSDVYSLGVIILRLLTGMPPLTLSEKVAEALGSDSLHLLIDKSAGDWPYIEAKQLALIGLSCTGMTRKKRPDLLNEVWIVIEPLTR 416          

Query:  399 RQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTH-----------VAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGAC--QDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTD---------------WPAEDALVFAKLALSCAELSKKDRPDLALVV 672
            + +T +E++ AT+NF  +  IGEGG+G V+KG +G              VA+K L+ +  QG K++L EV  L  + H N+V L+G C   +   LVYEYM  GSLE+ L R+  + PIPW+ R ++ +  A  L FLH+ K   +++RD K +N+LLD +F +K+SD GL++  P G    VT    T   GT  Y  PEY  TG+LT+KSD+YS G++ L++++ RP +  S   K  +E  N VD   P + D               +P + A   A +AL C     K RPD+A V+
Sbjct:   70 KAFTFNELKTATRNFKPNSMIGEGGFGCVYKGWIGERSLSPSKPGSGMVVAVKKLKSEGFQGHKEWLTEVHYLGRLHHMNLVKLIGYCLEGEKRLLVYEYMPKGSLENHLFRR-GAEPIPWKTRMKVAFSAARGLSFLHEAK---VIYRDFKASNILLDVDFNAKLSDFGLAKAGPTGDRTHVT----TQVIGTQGYAAPEYIATGRLTSKSDVYSFGVVLLELLSGRPTLDKS---KVGVER-NLVDWAIPYLVDRRKVFRIMDTKLGGQYPHKGACAAANIALRCLNTEPKLRPDMADVL 359          

Query:   12 TNLVMVAVDKDKNSGYAFRWTTNNIDNPII----IAVHVKPKDIPHQEGQDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQNGVA------------------SCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTNKSLE-SIEL-SGRGQRSSFNHTSSLNEN-ESSRLHKYGLVD--GQKLE----RGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEE-RTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLG 683
             N  +VA+DKDKNS +A RW  +++ N II    I +HV+ K+  H       G N+   D+ ++  +F P R  C    + M E I++DTD+++ +L+Y   N V N+V+G+ S   K+  +RSL       KF    DVA++V+KS P++ SVYVI+K K+  SR A  P+ N +                   S +S+ + R+   +R    N    G  P+ +  K  + TN SL+ + E   G+GQR+S   +S  +E+ +   +   G +D   +  +     GSS  S SQ   D+EAEMK L+++L+QTM+MY+SACKEA+ AK KANE+N+WK+EE R  EE   + EAALA+AE+EKAK  AAL+  ++A +MAE E Q+R  AE KARRE +E+D+AL+ + + DVRYR+Y++DEIE AT+ F+ + KIGEGGYGPV+ G L HT VAIK+LRPDA QG+KQF QEVEVL +IRHP+MVLLLGAC +YGCLVYE+MDNGSLEDRL R+ NSPP+ W+KRF+I  EIATAL FLHQ KPE +VHRDLKPAN+LLDKN+VSKISDVGL+RLVP  VA++VTQYHMTSAAGT CYIDPEYQQTGKLTTKSDI+SLGIM LQIITA+ PMGL+HHV +AI+ G F DMLDPVV DWP E+AL FAKL L CAEL K+DRPDL   ++PEL R ++LG
Sbjct:   14 VNSTVVAIDKDKNSHFAVRWAVDHLFNMIINSKMILLHVRLKNSNH-------GGNI---DDSELNQLFVPYRGYCARKGISMMEVILDDTDVSKAVLDYVNNNLVTNLVLGSSS---KSPFARSL-------KFTKSHDVASSVLKSTPEFCSVYVISKGKVHSSRTAQRPITNTLVPPRVPSSTFHLPDPDHDRSPRSQRNGRNTVPERYSHENK---GFKPVREMHK--IPTNGSLDFNYEFRQGKGQRNSTGRSSFSDESSDVGSMMMMGSIDLSAENFDMVGGSGSSDESASQSTRDIEAEMKRLKIELKQTMDMYSSACKEALNAKKKANELNQWKMEEARRFEEARNAEEAALAVAEMEKAKCRAALEAAEKAQRMAELEGQRRKQAEMKARRESQEKDRALSALVQNDVRYRKYSIDEIEVATERFANNRKIGEGGYGPVYHGTLDHTPVAIKVLRPDAAQGKKQFQQEVEVLSSIRHPHMVLLLGACPEYGCLVYEFMDNGSLEDRLFRRGNSPPLSWRKRFQIAAEIATALSFLHQAKPEPLVHRDLKPANILLDKNYVSKISDVGLARLVPASVANTVTQYHMTSAAGTFCYIDPEYQQTGKLTTKSDIFSLGIMLLQIITAKSPMGLAHHVSRAIDKGTFKDMLDPVVPDWPVEEALNFAKLCLRCAELRKRDRPDLGKEIVPELLRLRNLG 692          

Query:   13 NLVMVAVDKDKNSGYAFRWTT----NNIDNPIIIAVHVKPKDIPHQEGQDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVES-RPAITPLQNGVASCK-------------SENDL-----RSNTFK---------RGGSTNSSKSGKSPLHDKLKSSLSTNKSLESIELSGRGQRSSFNHTSSLNENESSRLHKYGLVD-----GQKLERGSSTASNSQI---LGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEE-RTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLG 683
            N  +VA+DK+K+S YA RW      N I NP++I VHV+ K+  H       G N+   + +D+  +F P R  C    + M E +++D+D+A+ IL+Y   N V N+V+GA    TKN  +RS         F    +V ++++KS PD+ SVYVI+K   V+S RPA  P+ N +A  +             SE DL     RS   K         R     + K  KSP++     S+  N            QR+     SS ++         G VD           G+S++S   I     D+EAEM+ L+L+L+QTM+MY+SACKEA+ AK KANE+N+WK+EE R  E+  +S EAALA+AE+EKAK   A++  ++A +MAE E Q+R  AE KA  E +++D+A++ +A  DVRYR+Y+++EIE AT+ F+   KIGEGGYGPV+ G+L HT VAIK+LRPDA QG+KQF QEVEVLC+IRHP+MVLLLGAC +YGCLVYE+M+NGSLEDRL R  NSPP+ W+KRFEI  EIATAL FLHQ KPE +VHRDLKPAN+LLDKN+VSKISDVGL+RLVP  +ADSVTQ+HMTSAAGT CYIDPEYQQTG LTTKSD+YSLGI+ LQIIT RPPMGL+H V +AI  G F +MLDPVV DWP ++A  FA LAL CAEL K+DRPDL   V+P L R K+ G
Sbjct:   18 NSTVVAIDKEKHSSYAVRWAVDHLLNMIHNPVMILVHVRTKNSNH-------GANL---NNDDLNQLFIPYRGYCARKGISMTEVVLDDSDVAKTILDYVNNNLVNNLVLGAS---TKNTFARSF-------MFSKPHEVQSSIMKSTPDFCSVYVISKGGKVQSSRPAQRPITNTLAPPRVPSSGFLIQSLSDSEQDLIPRVQRSARNKPNETTYPHNRAAFNTTQKGYKSPIN----GSMDFNNGFNQAAF----QRNP-TLQSSFSDESDGGFGVMGSVDLSSQNSMDFYHGASSSSEESIPQSTKDIEAEMRRLKLELKQTMDMYSSACKEALTAKRKANELNQWKIEEARKFEKARLSEEAALAVAEIEKAKCRTAVEAAEKAQRMAELEGQRRKQAEMKAVSEEKDKDRAVSALAHNDVRYRKYSIEEIEEATERFANHRKIGEGGYGPVYNGELDHTPVAIKVLRPDAAQGKKQFQQEVEVLCSIRHPHMVLLLGACPEYGCLVYEFMENGSLEDRLFRTGNSPPLSWRKRFEIAAEIATALSFLHQAKPEPLVHRDLKPANILLDKNYVSKISDVGLARLVPASIADSVTQFHMTSAAGTFCYIDPEYQQTGMLTTKSDVYSLGILLLQIITGRPPMGLAHQVSRAISKGTFKEMLDPVVPDWPVQEAQSFATLALKCAELRKRDRPDLGKEVVPHLIRLKNFG 700          

Query:   13 NLVMVAVDKDKNSGYAFRWTT----NNIDNPIIIAVHVKPKDIPHQEGQDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVES-RPAITPLQNGVASCK-------------SENDL-----RSNTFK---------RGGSTNSSKSGKSPLHDKLKSSLSTNKSLESIELSGRGQRSSFNHTSSLNENESSRLHKYGLVD-----GQKLERGSSTASNSQI---LGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEE-RTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLG 683
            N  +VA+DK+K+S YA RW      N I NP++I VHV+ K+  H       G N+   + +D+  +F P R  C       K  +++D+D+A+ IL+Y   N V N+V+GA    TKN  +RS         F    +V ++++KS PD+ SVYVI+K   V+S RPA  P+ N +A  +             SE DL     RS   K         R     + K  KSP++     S+  N            QR+     SS ++         G VD           G+S++S   I     D+EAEM+ L+L+L+QTM+MY+SACKEA+ AK KANE+N+WK+EE R  E+  +S EAALA+AE+EKAK   A++  ++A +MAE E Q+R  AE KA  E +++D+A++ +A  DVRYR+Y+++EIE AT+ F+   KIGEGGYGPV+ G+L HT VAIK+LRPDA QG+KQF QEVEVLC+IRHP+MVLLLGAC +YGCLVYE+M+NGSLEDRL R  NSPP+ W+KRFEI  EIATAL FLHQ KPE +VHRDLKPAN+LLDKN+VSKISDVGL+RLVP  +ADSVTQ+HMTSAAGT CYIDPEYQQTG LTTKSD+YSLGI+ LQIIT RPPMGL+H V +AI  G F +MLDPVV DWP ++A  FA LAL CAEL K+DRPDL   V+P L R K+ G
Sbjct:   18 NSTVVAIDKEKHSSYAVRWAVDHLLNMIHNPVMILVHVRTKNSNH-------GANL---NNDDLNQLFIPYRGYC-----ARKGVVLDDSDVAKTILDYVNNNLVNNLVLGAS---TKNTFARSF-------MFSKPHEVQSSIMKSTPDFCSVYVISKGGKVQSSRPAQRPITNTLAPPRVPSSGFLIQSLSDSEQDLIPRVQRSARNKPNETTYPHNRAAFNTTQKGYKSPIN----GSMDFNNGFNQAAF----QRNP-TLQSSFSDESDGGFGVMGSVDLSSQNSMDFYHGASSSSEESIPQSTKDIEAEMRRLKLELKQTMDMYSSACKEALTAKRKANELNQWKIEEARKFEKARLSEEAALAVAEIEKAKCRTAVEAAEKAQRMAELEGQRRKQAEMKAVSEEKDKDRAVSALAHNDVRYRKYSIEEIEEATERFANHRKIGEGGYGPVYNGELDHTPVAIKVLRPDAAQGKKQFQQEVEVLCSIRHPHMVLLLGACPEYGCLVYEFMENGSLEDRLFRTGNSPPLSWRKRFEIAAEIATALSFLHQAKPEPLVHRDLKPANILLDKNYVSKISDVGLARLVPASIADSVTQFHMTSAAGTFCYIDPEYQQTGMLTTKSDVYSLGILLLQIITGRPPMGLAHQVSRAISKGTFKEMLDPVVPDWPVQEAQSFATLALKCAELRKRDRPDLGKEVVPHLIRLKNFG 695          

Query:   90 MKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAITPLQNGVA------------------SCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTNKSLE-SIEL-SGRGQRSSFNHTSSLNEN-ESSRLHKYGLVD--GQKLE----RGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEE-RTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLG 683
            M E I++DTD+++ +L+Y   N V N+V+G+ S   K+  +RSL       KF    DVA++V+KS P++ SVYVI+K K+  SR A  P+ N +                   S +S+ + R+   +R    N    G  P+ +  K  + TN SL+ + E   G+GQR+S   +S  +E+ +   +   G +D   +  +     GSS  S SQ   D+EAEMK L+++L+QTM+MY+SACKEA+ AK KANE+N+WK+EE R  EE   + EAALA+AE+EKAK  AAL+  ++A +MAE E Q+R  AE KARRE +E+D+AL+ + + DVRYR+Y++DEIE AT+ F+ + KIGEGGYGPV+ G L HT VAIK+LRPDA QG+KQF QEVEVL +IRHP+MVLLLGAC +YGCLVYE+MDNGSLEDRL R+ NSPP+ W+KRF+I  EIATAL FLHQ KPE +VHRDLKPAN+LLDKN+VSKISDVGL+RLVP  VA++VTQYHMTSAAGT CYIDPEYQQTGKLTTKSDI+SLGIM LQIITA+ PMGL+HHV +AI+ G F DMLDPVV DWP E+AL FAKL L CAEL K+DRPDL   ++PEL R ++LG
Sbjct:    1 MMEVILDDTDVSKAVLDYVNNNLVTNLVLGSSS---KSPFARSL-------KFTKSHDVASSVLKSTPEFCSVYVISKGKVHSSRTAQRPITNTLVPPRVPSSTFHLPDPDHDRSPRSQRNGRNTVPERYSHENK---GFKPVREMHK--IPTNGSLDFNYEFRQGKGQRNSTGRSSFSDESSDVGSMMMMGSIDLSAENFDMVGGSGSSDESASQSTRDIEAEMKRLKIELKQTMDMYSSACKEALNAKKKANELNQWKMEEARRFEEARNAEEAALAVAEMEKAKCRAALEAAEKAQRMAELEGQRRKQAEMKARRESQEKDRALSALVQNDVRYRKYSIDEIEVATERFANNRKIGEGGYGPVYHGTLDHTPVAIKVLRPDAAQGKKQFQQEVEVLSSIRHPHMVLLLGACPEYGCLVYEFMDNGSLEDRLFRRGNSPPLSWRKRFQIAAEIATALSFLHQAKPEPLVHRDLKPANILLDKNYVSKISDVGLARLVPASVANTVTQYHMTSAAGTFCYIDPEYQQTGKLTTKSDIFSLGIMLLQIITAKSPMGLAHHVSRAIDKGTFKDMLDPVVPDWPVEEALNFAKLCLRCAELRKRDRPDLGKEIVPELLRLRNLG 607          

Query:   13 NLVMVAVDKDKNSGYAFRWTTNNI--DNPIIIAVHVKPK--------------DIPHQEGQDREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESR------PAITPL-----QNGVA------SCKSENDLRSNTFK---RGGSTNSSKSGKSP-----LHDKLKSSLSTNKSLESIELSGRG--QRSSFNHTSSLNENESS-RLHKYGLVD---------GQK-LERGSSTA------------SNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKL-EERTVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLG 683
             LV VA+D+DKNS  A +W  +N+      ++ VHVKP+                  Q   D   V   P  E     +F P R +C+   ++ K+ ++ ++D+AR ++EYA +  ++ +VVG  SS     L           +F    D+  A+ K+APD+ +VY I K K+   +      P+++PL     QNG+       S  +       +F+   R    + S S + P     L  +    LS   S  S   SGR   +R+S +   + + N +  RL  +  VD         G++ ++  S TA            S SQ   D+EAEM+ L+L+L+QTMEMY++ACKEA+ AK+KA E+ +WKL EER  EE  ++ EAALA+AE EKAK+ AA++  + A ++A+ E++KR+ AE KA +E E R +A+N +A+ DVRYR+Y+++EIE+AT+ F    KIGEG YGPV+K  L HT VA+K LRPDA QGR QF +EVEVLC+IRHPNMVLLLGAC + GCLVYE+M NGSLEDRL R+ +SP + WQ RF I  EI T LLFLHQTKPE +VHRDLKPAN+LLD+NFVSK++DVGL+RLVPP VA++VTQYHMTS AGT CYIDPEYQQTG L  KSDIYSLGIMFLQ+IT +PPMGL+H+V++A+E GN  D+LDP V+DWP ED   FAKLAL CAE+ +KDRPDL+ V++PEL+R + L 
Sbjct:   16 GLVAVAIDRDKNSQGALKWAVDNLLQKGQTVVLVHVKPRASSLSTNPSINSNSSKTSQINGDSSLVCGEP--EGSYKQLFLPFRCLCSRKDIQCKDVLLEESDVARALVEYANQVMIEVLVVG--SSSKGGFL-----------RFNKPIDIPGAITKTAPDFCTVYAITKGKLSTKKTASRAAPSVSPLRIQLQQNGLKPHPPLPSATTNTRAERQSFESQHRRSLDDQSDSFRPPYNKRGLTGRSYGELSIPDSEISFNSSGRPSIERNSPSLYDNSDPNRTPPRLSNFSDVDYCSFESMTFGRRSMDLSSPTAFSTGSFENERFSSASQGGDDVEAEMRRLKLELKQTMEMYSTACKEALTAKHKATELQRWKLAEERKFEEAKLAEEAALAIAEKEKAKSKAAMEAAEAAQRIADIESRKRVDAETKALKESEARTKAVNALAK-DVRYRKYSIEEIEDATEFFDDKYKIGEGSYGPVYKCYLDHTPVAVKALRPDAAQGRSQFQKEVEVLCSIRHPNMVLLLGACPECGCLVYEFMANGSLEDRLFRQGDSPALSWQTRFRIAAEIGTVLLFLHQTKPEPLVHRDLKPANILLDRNFVSKLADVGLARLVPPSVANTVTQYHMTSTAGTFCYIDPEYQQTGMLGVKSDIYSLGIMFLQLITGKPPMGLTHYVERALEKGNLKDLLDPAVSDWPVEDTTEFAKLALKCAEIRRKDRPDLSKVILPELNRLRVLA 737          

Query:    1 MPTNGSI---DRPNTNLVMVAVDKDKNSGYAFRWTTNNI--DNPIIIAVHVKPKDIP--------HQEGQDREGVNVFPPDEEDVAN-VFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESR------PAITPLQNGVAS----------CKSENDLRSN--TF-------------------KRGGSTNSSKSGKSPL----HDKLKSSLSTNKSLESIELSGR-----------------------GQRSSFNHTSSLNENESSRLHKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERTVEEVMMSREAALAMAEVE-KAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLGCKLQNHQQNLSHAPRP-PT 701
            MP N ++   +  ++ +V VA+DKDK+S +A +W  +N+      +I VHVK +  P            +  +  ++   D E ++  +F P R  C    ++ ++ ++ ++D+A+ ++EY  +  ++ +VVG  SS     L           +F    D+  ++ K+APD+ +VY+I+K K+   R      P   PL++ V              S N LR++  +F                   +R    + S+S +SP     + +    L+  +S  S   SGR                          S  +++SSL+++ +       +      E     +S SQ + D+EAEM+ L+L+L+QTMEMY++ACKEA+ AK KA E+ +WKLEE    E   + E A      + KAK+ AA++  + A ++AE E +KR++AE KA +E EE+ +AL  +A +DVRYR+Y++++IE AT+ F+   KIGEGGYGPV+K  L HT VA+K+LRPDA QGR QF QEVEVL  IRHPNMVLLLGAC + GCLVYE+M NGSLEDRL R  NSPP+ WQ RF I  EI T LLFLHQ KPE +VHRDLKP N+LLD+NFVSKISDVGL+RLVPP VAD+VTQY MTS AGT CYIDPEYQQTG L  KSDIYSLGIMFLQ+ITA+PPMGL+H+V++A+E G  VD+LDPVV+DWP ED   FAKLAL CAEL +KDRPDLA V++PEL+R + L  +  +H   + ++P P PT
Sbjct:    3 MPKNNNVGVKEGGSSGVVAVAIDKDKSSQHALKWAVDNLLQRGQSVILVHVKLRPSPLNNSASLHASSAKLSQDSSLVCRDPEGISKEIFLPFRCFCTRKDIQCQDVLLEESDVAKALVEYVNQAAIEVLVVG--SSSKGGFL-----------RFNKPTDIPGSITKNAPDFCTVYIISKGKIQTMRSASRSAPMTAPLRSSVQPPSLKPPQPMPSTSANSLRADRRSFESNQRRSVEDQQRRSMEDQQRRSIDDQSESFRSPFTRRGNGRSYGDLTVPESDISFISSGRPSIDRIFPSLYDNNDPSRTPPRLSNFSDMDYSSSLDQSSNYGRRSVDMNSPTDFE-SERFSSASQSIDDVEAEMRRLKLELKQTMEMYSTACKEALTAKQKATELQRWKLEEERKLEEARNAEEAALAIAEKEKAKSKAAMEAAEAAQRIAELEAKKRVNAEMKALKESEEKTKALTALANSDVRYRKYSIEDIELATEFFAEKYKIGEGGYGPVYKCYLDHTPVAVKVLRPDAAQGRSQFQQEVEVLSCIRHPNMVLLLGACPECGCLVYEFMANGSLEDRLFRLGNSPPLSWQMRFRIAAEIGTGLLFLHQAKPEPLVHRDLKPGNILLDRNFVSKISDVGLARLVPPTVADTVTQYRMTSTAGTFCYIDPEYQQTGMLGVKSDIYSLGIMFLQLITAKPPMGLTHYVERALEKGTLVDLLDPVVSDWPMEDTEEFAKLALKCAELRRKDRPDLAKVILPELNRLRTLADE-SSHSVVVGNSPLPSPT 768          

Query:   15 VMVAVDKDKNSGYAFRWTTNNIDNP--IIIAVHVKPKDIPHQEGQ--DREGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPAIT---PL--------------------------QNGVASCKSENDLRSNTFKRGGSTNSSKSGKSPLHDKLKSSLSTNK-SLESIELSGRGQRSSFNHTSSLNENESSRL---HKYGLVDGQKLERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEER-TVEEVMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLG 683
            V +A+D+DK S  A +W  +N+  P   +  +HVK K      G   ++ G        +DV  +F P R  C    +  +E ++ + D A GI+EY + N +  +V+GA                T+ K+ K  D V  AVIK AP++ +VY I+K K+   R A +   PL                             V S + E +++S   ++     + ++  S   D   S +S+++ S++  E      RS++  +SS +E +S  L   +       Q+  R SS +  SQ   D+E+EM+ L+L+L+ TM+MYNSACKEAI AK    E++KWK E +  +EE ++++EAA+A+AE EKAK+ AA++ ++ A +MAE E QKR   E  A RE+E  ++A++ +  ++  YR+YT++EIE  T  FS S KIGEG YG V+KG L +T VAIK++RPDA QGR QF QEVEVL  IRHPNMVLLLGAC +YGCLVYEYM NGSL+D LLR+ NSP + WQ RF I  EIAT+L FLHQ KPE +VHRDLKPAN+LLD++ VSKISDVGL+RLVPP + D  T Y MTS AGTLCYIDPEYQQTG L TKSDIYS GI+ LQI+TA+ PMGL++ V+KAIE GNF  +LDP+VTDWP E+AL+ AK+ L CAEL +KDRPDL  VV+P L R  +L 
Sbjct:   14 VAIAIDRDKGSQAALKWAVDNLLTPGETLTLIHVKVKQTLANNGTQPNKSG--------DDVKELFLPFRCFCTRKDINCEEVVLENVDAAEGIIEYVQENAIDILVLGASKI-------------TLLKRLKAVD-VTNAVIKGAPNFCTVYAISKGKISSVRSATSSPPPLCTIRPQLPARSSNANNNNFSPRAQRRLQSVQSIQDEIEIKSPYLRKEYDQGTYQALVS---DSDLSFVSSDRPSMDWFE----DNRSNYATSSSSSEKQSIDLCSSYSAFSTSSQESGRLSSLSMYSQ--DDVESEMRRLKLELKYTMDMYNSACKEAIAAKKTTIELHKWKEERKHKLEEAILAKEAAMAIAENEKAKSRAAMEALEAAHRMAETEAQKRKQIETAALREVEHENKAMHALPHSNRMYRKYTIEEIEQGTTKFSDSHKIGEGSYGTVYKGTLDYTPVAIKVVRPDATQGRSQFQQEVEVLTCIRHPNMVLLLGACAEYGCLVYEYMSNGSLDDCLLRRGNSPVLSWQLRFRIAAEIATSLNFLHQLKPEPLVHRDLKPANILLDQHMVSKISDVGLARLVPPTIDDIATHYRMTSTAGTLCYIDPEYQQTGMLGTKSDIYSFGIVLLQILTAKTPMGLTNQVEKAIEEGNFAKILDPLVTDWPIEEALILAKIGLQCAELRRKDRPDLGTVVLPGLKRLMNLA 689          

Query:   15 VMVAVDKDKNSGYAFRWTTNNIDN--PIIIAVHVKPKDIPHQEGQD-REGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPA--ITPLQNGVAS-------------CKSENDLRSNTFKRGGSTNSSKSG--KSPL-HDKLKSSLSTNKS---------LESIEL----SGRGQ--RSSFNH-------TSSLNENESSRL--HKYGL--VDGQKLERGSSTASN----------SQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERTVEEVM-MSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLG 683
            V +A+DKDK+S  A +WT  N+      +  +HV PK    Q   D  EG+      E+   ++F      C+   +   + ++ D D  + I+EY   + ++N+V+GAP        SR+  MR    +FK   D+ T+V K+APD+ +VYVI+K K+   R A  + P    V S              K+ N       +R   ++ ++ G  K P  H KL    S ++S          ES +L    SGR    RSSF +       TS ++ +    +  H+ G+   D   L  GSS+ S+          SQ L D+EA+MK LRL+L+QTM+MY+SAC+EA+ A+N+A E+ K + EE    E + M+ E A+++ E E+AKA  AL+  + A ++AE E ++R+HAE K  +E +   +       + VRYR+Y++ EIE  T NF+ S K+GEGGYGPVF+G L HT VA+K+LRPDA QGR QF +EVEVL  IRHPNMVLLLGAC +YG LVYEYM  GSL+DRL R+ N+PPI WQ RF I  EIAT LLFLHQTKPE IVHRDLKP NVLLD N+VSKISDVGL+RLV P VA++VTQY +TSAAGT CYIDPEYQQTG L  KSD+YSLGIM LQ++TA+ PMGL+++V++AIE G   DMLDP V DWP E+AL  AKL+L CAEL +KDRPDL   V+PELSR +++G
Sbjct:   18 VAIAIDKDKSSQNAIKWTLENLATRGQTLALIHVLPKS---QSSLDIEEGITHKQQMEKQTKDLFVSFHCYCSRKEIHCLDVVLEDVDKVKAIVEYVTVSAIENLVLGAP--------SRNSFMR----RFK--TDLPTSVSKAAPDFCNVYVISKGKISSLRNASRLAPYHPSVLSEVDDHETIAIERKHKTANTPALPKGRRSIDSDVTRLGLPKPPHGHMKLMGDFSDSESEFSFISASQQESSDLSFISSGRPSVDRSSFTYDLPESARTSRMSTSSEQSIGSHRLGIKFTDLSYLN-GSSSVSDESGRTSCSFSSQSLNDVEAQMKRLRLELKQTMDMYSSACREALTARNEATELQKLRTEEERRLEELKMTEETAMSIVENERAKAKTALEAAEAANRLAEVEAKRRVHAEMKVLKESDSFSR------HSIVRYRKYSVQEIEEGTANFAESRKVGEGGYGPVFRGHLDHTSVAVKVLRPDAAQGRSQFHKEVEVLSCIRHPNMVLLLGACPEYGILVYEYMARGSLDDRLFRRGNTPPISWQLRFRIAAEIATGLLFLHQTKPEPIVHRDLKPGNVLLDHNYVSKISDVGLARLV-PAVAENVTQYRVTSAAGTFCYIDPEYQQTGMLGVKSDVYSLGIMLLQLLTAKQPMGLAYYVEQAIEEGTLKDMLDPAVPDWPLEEALSLAKLSLQCAELRRKDRPDLGKEVMPELSRLREIG 719          

Query:   15 VMVAVDKDKNSGYAFRWTTNNIDN--PIIIAVHVKPKDIPHQEGQD-REGVNVFPPDEEDVANVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVESRPA--ITPLQNGVAS-------------CKSENDLRSNTFKRGGSTNSSKSG--KSPL-HDKLKSSLSTNKS---------LESIEL----SGRGQ--RSSFNH-------TSSLNENESSRL--HKYGL--VDGQKLERGSSTASN----------SQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERTVEEVM-MSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLG 683
            V +A+DKDK+S  A +WT  N+      +  +HV PK    Q   D  EG+      E+   ++F      C+   +   + ++ D D  + I+EY   + ++N+V+GAP        SR+  MR    +FK   D+ T+V K+APD+ +VYVI+K K+   R A  + P    V S              K+ N       +R   ++ ++ G  K P  H KL    S ++S          ES +L    SGR    RSSF +       TS ++ +    +  H+ G+   D   L  GSS+ S+          SQ L D+EA+MK LRL+L+QTM+MY+SAC+EA+ A+N+A E+ K + EE    E + M+ E A+++ E E+AKA  AL+  + A ++AE E ++R+HAE K  +E +   +       + VRYR+Y++ EIE  T NF+ S K+GEGGYGPVF+G L HT VA+K+LRPDA QGR QF +EVEVL  IRHPNMVLLLGAC +YG LVYEYM  GSL+DRL R+ N+PPI WQ RF I  EIAT LLFLHQTKPE IVHRDLKP NVLLD N+VSKISDVGL+RLV P VA++VTQY +TSAAGT CYIDPEYQQTG L  KSD+YSLGIM LQ++TA+ PMGL+++V++AIE G   DMLDP V DWP E+AL  AKL+L CAEL +KDRPDL   V+PELSR +++G
Sbjct:   18 VAIAIDKDKSSQNAIKWTLENLATRGQTLALIHVLPKS---QSSLDIEEGITHKQQMEKQTKDLFVSFHCYCSRKEIHCLDVVLEDVDKVKAIVEYVTVSAIENLVLGAP--------SRNSFMR----RFK--TDLPTSVSKAAPDFCNVYVISKGKISSLRNASRLAPYHPSVLSEVDDHETIAIERKHKTANTPALPKGRRSIDSDVTRLGLPKPPHGHMKLMGDFSDSESEFSFISASQQESSDLSFISSGRPSVDRSSFTYDLPESARTSRMSTSSEQSIGSHRLGIKFTDLSYLN-GSSSVSDESGRTSCSFSSQSLNDVEAQMKRLRLELKQTMDMYSSACREALTARNEATELQKLRTEEERRLEELKMTEETAMSIVENERAKAKTALEAAEAANRLAEVEAKRRVHAEMKVLKESDSFSR------HSIVRYRKYSVQEIEEGTANFAESRKVGEGGYGPVFRGHLDHTSVAVKVLRPDAAQGRSQFHKEVEVLSCIRHPNMVLLLGACPEYGILVYEYMARGSLDDRLFRRGNTPPISWQLRFRIAAEIATGLLFLHQTKPEPIVHRDLKPGNVLLDHNYVSKISDVGLARLV-PAVAENVTQYRVTSAAGTFCYIDPEYQQTGMLGVKSDVYSLGIMLLQLLTAKQPMGLAYYVEQAIEEGTLKDMLDPAVPDWPLEEALSLAKLSLQCAELRRKDRPDLGKEVMPELSRLREIG 719          

Query:    4 NGSIDRPNTNLVMVAVDKDKNSGYAFRWTTNNIDN--PIIIAVHVKPKDIPHQEGQDREGVNVFPPDEEDVA-NVFDPLREMCNDNVVKMKEAIINDTDIARGILEYAKRNYVQNIVVGAPSSYTKNVLSRSLNMRTISKKFKGHDDVATAVIKSAPDYSSVYVIAKEKMVE----SRPAITPLQNGVASCKSENDLRSNTFK---------RGGST-----NSSKSGKSPLHDK--------------LKSSLSTNKSLESIELSGRG--QRSSFNHTSSLNENESSRLHKYGLVDGQKL-----------------------ERGSSTASNSQILGDMEAEMKELRLKLRQTMEMYNSACKEAILAKNKANEINKWKLEERTVEE-VMMSREAALAMAEVEKAKAVAALKTVDEAMKMAEKETQKRLHAERKARREIEERDQALNVIARTDVRYRQYTLDEIENATKNFSLSMKIGEGGYGPVFKGQLGHTHVAIKILRPDAHQGRKQFLQEVEVLCNIRHPNMVLLLGACQDYGCLVYEYMDNGSLEDRLLRKHNSPPIPWQKRFEICYEIATALLFLHQTKPESIVHRDLKPANVLLDKNFVSKISDVGLSRLVPPGVADSVTQYHMTSAAGTLCYIDPEYQQTGKLTTKSDIYSLGIMFLQIITARPPMGLSHHVKKAIENGNFVDMLDPVVTDWPAEDALVFAKLALSCAELSKKDRPDLALVVIPELSRFKDLG 683
            NG+     +  V VA+DKDK S +A +WT +N+ +    I  +HV  +   H      EG        E +A ++F      C+   +  ++ ++ D D  R I EY   + ++N+VVG+ S        R+  MR    +FK   D+ T V KSAPD+ +VYVI+K K+      SRPA  P QN +  C+ +N       K           GST      S ++ +SPL  +                S  S   S  S   SGR   +RSSF    SL+  ES+R  +      Q +                       E G +++ +SQ L D+EAEMK LRL+L+QTM+MY++ACKEA+ A+ +A E+ K + EE    E    S EAA+++ E E+AKA AAL+  + A ++AE E+++RL AE K  +E +         +R  VRYR+YT+DEIE AT NF+ S K+GEGGYGPVF+G L HT VA+K+LRPDA QGR QF +EVEVL  IRHPNMVLLLGAC ++G LVYEYM  GSLEDRL  + N+PPI WQ RF I  EIAT LLFLHQTKPE IVHRDLKP NVLLD N+VSKISDVGL+RLV P VA++VTQY +TSAAGT CYIDPEYQQTG L  KSD+YSLGIM LQI+TA+ PMGL+++V++AIE G   DMLDP V DWP E+AL  AKL+L CAEL +KDRPDL   ++PEL+R +++G
Sbjct:    7 NGAKKETGSGSVAVAIDKDKGSQHALKWTIDNLASRGQTISLIHVLCRS--HSSSDLEEGTPQQKQQMEKIAKDLFVSFHCYCSRKEINCRDILLEDADKVRAITEYVSSSAIENLVVGSAS--------RNGFMR----RFK--TDLPTTVSKSAPDFCNVYVISKGKIASVRNASRPA--PYQNSMQQCEIDNHHPHTPDKAPKYHDHPNSAGSTPSRPRKSVEADRSPLVKRKPYGDFYDSDSDLSFISPSSHRDSDISFISSGRPSVERSSF----SLDFPESARTSRMSTSSEQSIGSNRLGIKFSDPDFLNESSTFSEESGRTSSYSSQSLDDVEAEMKRLRLELKQTMDMYSTACKEALSARQQATELQKLRTEEERRLEEAKSSEEAAMSIVEKERAKAKAALEAAEAAKRLAEVESKRRLTAEMKTMKESDS-------FSRGFVRYRKYTVDEIEEATSNFAESQKVGEGGYGPVFRGFLDHTSVAVKVLRPDAAQGRSQFQKEVEVLSCIRHPNMVLLLGACPEFGILVYEYMAKGSLEDRLFMRGNTPPITWQLRFRIAAEIATGLLFLHQTKPEPIVHRDLKPGNVLLDYNYVSKISDVGLARLV-PAVAENVTQYRVTSAAGTFCYIDPEYQQTGMLGVKSDVYSLGIMLLQILTAKQPMGLAYYVEQAIEEGTLKDMLDPAVPDWPIEEALSLAKLSLQCAELRRKDRPDLGKEILPELNRLREIG 717