Vfaba.Hedin2.R1.2g174240.1

Query:    1 MSLPPPTGPPQ-QN-TMVAVDRDKNSAYAFRWAVNHLDNPVIIAVHVKHKNLSNQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVN--QIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSHRPPTMPT 709
            MS+  P+G PQ QN TMVAVD+DKNSAYAFRWA+NHLDNPVI+AVHVKHKNL N GTNV+PPDE+DV+ IF+NLRAMCQ KA+TMKEAVIDD+DVVKGLL+FA RN IHSIV+GAS KNH+ S+KKFK  +DI   +IK APDYCSVYIISKLKI SARSAVR M N  Q IP K LPVQ    + EFE G+RS+LPR+  T EGS ESRSFDSI+  KG TRERPRS GSN+S+D ID+P  RGR+WASMDERDMAALGPI      D+D+ DS GTPS S+TS++LEAEMKRLR ELKQTMDMYSSACKQAISAKNQ +QIRRW+VEEE+KV EVR+SQEAALAMAEREKARAKAA+EAAE+AK KAE EA RRREAEMKA KEAEERDRVLTALAQ+DNRYRKYTMEEIEVAT++FSPSKK+GEGGYGPV+KGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYE+MDNGSLEDRLFRKN S+PL+WQKRFQI+AEI+TALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVP SVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTT+SD+YSLG+MLLQ+ITA+PPMGL H VK+A+EK    +ILDPAVTDWPVE ALSFAK+ALGC EL KKDRP+LA VVLPE+NRLRDLG TD + FTDTK+N HS RPP MPT
Sbjct:    1 MSVQQPSGAPQPQNITMVAVDKDKNSAYAFRWAINHLDNPVIVAVHVKHKNLPNLGTNVYPPDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNGNQSIPSK-LPVQVGQ-HAEFETGIRSVLPRSSVTNEGS-ESRSFDSITATKGQTRERPRSAGSNLSMDKIDIPGGRGRHWASMDERDMAALGPI------DLDVPDSLGTPSASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIRRWKVEEERKVEEVRMSQEAALAMAEREKARAKAAMEAAEDAKRKAEQEAQRRREAEMKARKEAEERDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKNNSHSPRPP-MPT 703          

Query:    1 MSLPPPTGPPQQN-TMVAVDRDKNSAYAFRWAVNHLDNPVIIAVHVKHKNLSNQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSHRPPTMPT 709
            MSL  P+GPPQQN TMVAVD+ K+SAYAFRWA+  +DNP+IIAVHVK+KNL NQGTNV+PPDED+V+ IF+NLRA+C SK +TMKE V+DD DVVKGLL+FA RN++HS+V+GASTKN MPS+KKFKA+ DI T++IK AP YCSVYIISKLKIVS R AVR + NQIIP K L VQ S    EFE G+RSI PRT GT EGS ESRSFDSISTVKG  R+RPRS GSN S+D ID    RGR+WASMDER++AALGPIV+ NR ++ LIDS+GT  TS+TS+ELEAEMKRLRLELKQTMDMYSSACKQAISAKNQ +QIRRW+ EE +KVVEVRLSQEAALA+AEREKA+AKAALEAAEEAK KAE EA RR+EAEMKA KEAEER++VL ALAQ+DNRYRKYTM EIEVAT+RFSPSKK+GEGGYGPVFKGHL HT VA+KLLNPEA+QGRKQF QEVEVLS IRHPNMVLLLGACPEH CLVYEYM+NG+LEDRLFRKN SKPLSWQKRF+IAAEI+TALLFLHQTKPEPIVHRDLKPSNILLD+NYVSK++DVGLARLVPPSV D+VTQYYMTSAAGTFCYIDPEYQQTG+LT +SD+YSLGIMLLQIITARPPMGL+H VK+AIEK  F +ILD AVTDWPVEEALSFAK+AL CAELCKKDRP+LA VVLPE+NRLR LG  D   FTDTK+N HS RPP MPT
Sbjct:    1 MSLQEPSGPPQQNVTMVAVDKGKSSAYAFRWAIRCIDNPIIIAVHVKNKNLLNQGTNVYPPDEDEVAQIFNNLRALCPSKMVTMKEVVVDDQDVVKGLLDFANRNLVHSLVIGASTKNLMPSLKKFKASQDIPTSIIKSAPGYCSVYIISKLKIVSTRPAVREIGNQIIPTKQLAVQVSP---EFESGIRSIQPRTSGTNEGS-ESRSFDSISTVKGPARDRPRSAGSNQSMDNIDPSGGRGRHWASMDEREIAALGPIVDVNRHELYLIDSFGTHPTSHTSKELEAEMKRLRLELKQTMDMYSSACKQAISAKNQAEQIRRWKEEEGRKVVEVRLSQEAALAIAEREKAKAKAALEAAEEAKRKAEQEAQRRKEAEMKARKEAEERNKVLNALAQNDNRYRKYTMMEIEVATERFSPSKKLGEGGYGPVFKGHLHHTPVAVKLLNPEAAQGRKQFNQEVEVLSSIRHPNMVLLLGACPEHCCLVYEYMENGTLEDRLFRKNNSKPLSWQKRFKIAAEIATALLFLHQTKPEPIVHRDLKPSNILLDKNYVSKVADVGLARLVPPSVADSVTQYYMTSAAGTFCYIDPEYQQTGMLTPKSDIYSLGIMLLQIITARPPMGLSHHVKRAIEKDQFSEILDSAVTDWPVEEALSFAKLALNCAELCKKDRPNLASVVLPELNRLRGLGFNDNQVFTDTKNNSHSLRPP-MPT 705          

Query:   50 LSNQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSI-STVKGSTRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSHRPP 705
            L+ +GT VF PDE+DV+++F NLR +CQ K +T+KEAV+DD DVVKGLL+FA +N++HSIV+GASTKNH+PS+KKFKA ND  T M+K APDYCSVY+ISKLKIVSARSAVR M NQ  P+K LP Q SS   EFEGG+RSILPRTG T E +SESRSFDSI  TVKG+ RERPRS GSN SLD ID+P  RGR WASMDER+M  L PI + N SD+DLIDSYGT  T+ TS+ELEAEMKRLR ELKQTMDMYSSACKQAISAKNQ +QIR+W++E EKK VE RLSQEAALAMAEREKARAKAALEAAEEAK KAE E  RRRE EMKA KEAEERDRVLTALAQ DNRYRKYTM+EIEVAT++FS SKK+GEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYE+MDNGSLEDRLFR+  SKPLSWQKRFQIAA+I+TALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSV DNVTQYYMTSAAGTFCYIDPEYQQTGILTT+SDVYSLGIMLLQIITA+PPMGL H VKKA+E    E+ILDP VTDWPVE ALSFAK+AL C EL KKDRPSLA V+LPE+NRLRDLGDTD   FTDTK+N H+ RPP
Sbjct:    5 LNAEGTLVFEPDEEDVANVFGNLRGLCQRKVVTVKEAVVDDNDVVKGLLDFANKNLVHSIVIGASTKNHLPSLKKFKAFNDTPTAMMKSAPDYCSVYVISKLKIVSARSAVRSMANQTSPIKQLPFQVSS-QSEFEGGIRSILPRTGETNE-ASESRSFDSIVGTVKGTARERPRSAGSNQSLDNIDLPGGRGRQWASMDEREMVTLAPIDDVN-SDLDLIDSYGTKPTNLTSQELEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIRQWKLEGEKKAVEARLSQEAALAMAEREKARAKAALEAAEEAKRKAEQEVQRRREVEMKARKEAEERDRVLTALAQKDNRYRKYTMQEIEVATEKFSLSKKLGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRRQNSKPLSWQKRFQIAADIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVADNVTQYYMTSAAGTFCYIDPEYQQTGILTTQSDVYSLGIMLLQIITAKPPMGLAHHVKKAVENDQIEEILDPVVTDWPVEAALSFAKLALSCTELSKKDRPSLATVILPELNRLRDLGDTDNHVFTDTKNNCHTPRPP 658          

Query:   50 LSNQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVN--QIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSHRPPTMPT 709
            L+  GTNV+PPDE+DV+ IF+NLRAMCQ KA+TMKEAVIDD+DVVKGLL+FA RN IHSIV+GAS KNH+ S+KKFK  +DI   +IK APDYCSVYIISKLKI SARSAVR M N  Q IP K LPVQ    + EFE G+RS+LPR+  T EGS ESRSFDSI+  KG TRERPRS GSN+S+D ID+P  RGR+WASMDERDMAALGPI      D+D+ DS GTPS S+TS++LEAEMKRLR ELKQTMDMYSSACKQAISAKNQ +QIRRW+VEEE+KV EVR+SQEAALAMAEREKARAKAA+EAAE+AK KAE EA RRREAEMKA KEAEERDRVLTALAQ+DNRYRKYTMEEIEVAT++FSPSKK+GEGGYGPV+KGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYE+MDNGSLEDRLFRKN S+PL+WQKRFQI+AEI+TALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVP SVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTT+SD+YSLG+MLLQ+ITA+PPMGL H VK+A+EK    +ILDPAVTDWPVE ALSFAK+ALGC EL KKDRP+LA VVLPE+NRLRDLG TD + FTDTK+N HS RPP MPT
Sbjct:   26 LTVVGTNVYPPDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNGNQSIPSK-LPVQVGQ-HAEFETGIRSVLPRSSVTNEGS-ESRSFDSITATKGQTRERPRSAGSNLSMDKIDIPGGRGRHWASMDERDMAALGPI------DLDVPDSLGTPSASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIRRWKVEEERKVEEVRMSQEAALAMAEREKARAKAAMEAAEDAKRKAEQEAQRRREAEMKARKEAEERDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKNNSHSPRPP-MPT 677          

Query:   83 MKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSHRPPTMPT 709
            MKE V+DD DVVKGLL+FA RN++HS+V+GASTKN MPS+KKFKA+ DI T++IK AP YCSVYIISKLKIVS R AVR + NQIIP K L VQ S    EFE G+RSI PRT GT EGS ESRSFDSISTVKG  R+RPRS GSN S+D ID    RGR+WASMDER++AALGPIV+ NR ++ LIDS+GT  TS+TS+ELEAEMKRLRLELKQTMDMYSSACKQAISAKNQ +QIRRW+ EE +KVVEVRLSQEAALA+AEREKA+AKAALEAAEEAK KAE EA RR+EAEMKA KEAEER++VL ALAQ+DNRYRKYTM EIEVAT+RFSPSKK+GEGGYGPVFKGHL HT VA+KLLNPEA+QGRKQF QEVEVLS IRHPNMVLLLGACPEH CLVYEYM+NG+LEDRLFRKN SKPLSWQKRF+IAAEI+TALLFLHQTKPEPIVHRDLKPSNILLD+NYVSK++DVGLARLVPPSV D+VTQYYMTSAAGTFCYIDPEYQQTG+LT +SD+YSLGIMLLQIITARPPMGL+H VK+AIEK  F +ILD AVTDWPVEEALSFAK+AL CAELCKKDRP+LA VVLPE+NRLR LG  D   FTDTK+N HS RPP MPT
Sbjct:    1 MKEVVVDDQDVVKGLLDFANRNLVHSLVIGASTKNLMPSLKKFKASQDIPTSIIKSAPGYCSVYIISKLKIVSTRPAVREIGNQIIPTKQLAVQVSP---EFESGIRSIQPRTSGTNEGS-ESRSFDSISTVKGPARDRPRSAGSNQSMDNIDPSGGRGRHWASMDEREIAALGPIVDVNRHELYLIDSFGTHPTSHTSKELEAEMKRLRLELKQTMDMYSSACKQAISAKNQAEQIRRWKEEEGRKVVEVRLSQEAALAIAEREKAKAKAALEAAEEAKRKAEQEAQRRKEAEMKARKEAEERNKVLNALAQNDNRYRKYTMMEIEVATERFSPSKKLGEGGYGPVFKGHLHHTPVAVKLLNPEAAQGRKQFNQEVEVLSSIRHPNMVLLLGACPEHCCLVYEYMENGTLEDRLFRKNNSKPLSWQKRFKIAAEIATALLFLHQTKPEPIVHRDLKPSNILLDKNYVSKVADVGLARLVPPSVADSVTQYYMTSAAGTFCYIDPEYQQTGMLTPKSDIYSLGIMLLQIITARPPMGLSHHVKRAIEKDQFSEILDSAVTDWPVEEALSFAKLALNCAELCKKDRPNLASVVLPELNRLRGLGFNDNQVFTDTKNNSHSLRPP-MPT 622          

Query:    4 PPPTGPPQQNTMVAVDRDKNSAYAFRWAVNHLDNPVIIAVHVKHKNLSNQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANN--DIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGG-MRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRSTGSNMSLDC-IDVPSSRGRNWASMDERDMAALGPI-VESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLD--FTDTKS--NGHSHRPPTMP 708
            PP   P Q  TMVAVD+DKNS +AFRWAVNHLDNP+IIAVHVKHKN S+  TNVFPPDE+DV++IF+ LR MC  KA+ MKEAVIDD DVV+GLLE+A RN IHSIVVGASTKN + S+KKFK     DI T MIK APDYCSVYIISKLKIVSARSAVR M    +  K LPVQA  P  E EGG +R   PR+  TYEG  E         ++   RERPRS GS MS+D  IDV  +  R+W SMDER++A L  + V    S  D+ DS+GT S   +S+ELEAEMKRLRLELKQTMDMYSSACKQAISAKNQ +QIR+W++EE++KV  VRLSQEAALA+AEREK RAKAALEAAEEA+ +AE +A RR++AEMKA  EAEE++R L+ALA +DNRYRKYT+ EIE AT++F P  KIGEGGYGPV+KGHLDHT VAIK+L P+A  G KQFQQE+EVLSCIRHP+MVLLLGACPEHGCLVYEYMDNGSLEDRL+RKN S+P+SW+KRFQIAAEI+TALLFLHQ KPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVP SV D +TQYYMTSAAGTFCYIDPEYQQTGILTT+SDVYSLGIMLLQIITA+PPMGL H VKKAIEKG FE+ILDP VTDWPVEEALSFAK+AL C+EL KKDRP+LA VVLPE+NRL +L  T + D  F  ++   N ++  PPT P
Sbjct:    6 PPCAAPLQNTTMVAVDKDKNSVHAFRWAVNHLDNPIIIAVHVKHKNFSHHVTNVFPPDEEDVANIFNTLRGMCTRKAVKMKEAVIDDSDVVRGLLEYANRNAIHSIVVGASTKNPLISLKKFKTYQYQDIPTAMIKSAPDYCSVYIISKLKIVSARSAVRSMSKGFMAPKQLPVQACPP-SEPEGGSVRGQPPRSRSTYEGPVEP--------MRIQARERPRSAGS-MSIDINIDV-HTHPRHW-SMDEREIAGLVTMDVTKQDSIPDVSDSFGT-SGPQSSKELEAEMKRLRLELKQTMDMYSSACKQAISAKNQAEQIRQWKMEEDRKVEVVRLSQEAALALAEREKIRAKAALEAAEEARRRAEQDAQRRKDAEMKARLEAEEKERALSALAHNDNRYRKYTIVEIEAATEKFYPLNKIGEGGYGPVYKGHLDHTPVAIKILRPDAVHGMKQFQQEIEVLSCIRHPHMVLLLGACPEHGCLVYEYMDNGSLEDRLYRKNNSRPISWRKRFQIAAEIATALLFLHQNKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPASVADTMTQYYMTSAAGTFCYIDPEYQQTGILTTKSDVYSLGIMLLQIITAKPPMGLAHIVKKAIEKGRFEEILDPVVTDWPVEEALSFAKLALKCSELSKKDRPNLATVVLPELNRLSELELTLHNDQVFYSSEGVINSYAACPPTPP 706          

Query:    4 PPPTGPPQQNTMVAVDRDKNSAYAFRWAVNHLDNPVIIAVHVKHKNLSNQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANN--DIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGG-MRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRSTGSNMSLDC-IDVPSSRGRNWASMDERDMAALGPI-VESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLD--FTDTKS--NGHSHRPPTMP 708
            PP   P Q  TMVAVD+DKNS +AFRWAVNHLDNP+IIAVHVKHKN S+  TNVFPPDE+DV++IF+ LR MC  KA+ MKEAVIDD DVV+GLLE+A RN IHSIVVGASTKN + S+KKFK     DI T MIK APDYCSVYIISKLKIVSARSAVR M    +  K LPVQA  P  E EGG +R   PR+  TYEG  E         ++   RERPRS GS MS+D  IDV  +  R+W SMDER++A L  + V    S  D+ DS+GT S   +S+ELEAEMKRLRLELKQTMDMYSSACKQAISAKNQ +QIR+W++EE++KV  VRLSQEAALA+AEREK RAKAALEAAEEA+ +AE +A RR++AEMKA  EAEE++R L+ALA +DNRYRKYT+ EIE AT++F P  KIGEGGYGPV+KGHLDHT VAIK+L P+A  G KQFQQE+EVLSCIRHP+MVLLLGACPEHGCLVYEYMDNGSLEDRL+RKN S+P+SW+KRFQIAAEI+TALLFLHQ KPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVP SV D +TQYYMTSAAGTFCYIDPEYQQTGILTT+SDVYSLGIMLLQIITA+PPMGL H VKKAIEKG FE+ILDP VTDWPVEEALSFAK+ L C+EL KKDRP+LA VVLPE+NRL +L  T + D  F  ++   N ++  PPT P
Sbjct:    6 PPCAAPLQNTTMVAVDKDKNSVHAFRWAVNHLDNPIIIAVHVKHKNFSHHVTNVFPPDEEDVANIFNTLRGMCTRKAVKMKEAVIDDSDVVRGLLEYANRNAIHSIVVGASTKNPLISLKKFKTYQYQDIPTAMIKSAPDYCSVYIISKLKIVSARSAVRSMSKGFMAPKQLPVQACPP-SEPEGGSVRGQPPRSRSTYEGPVEP--------MRIQARERPRSAGS-MSIDINIDV-HTHPRHW-SMDEREIAGLVTMDVTKQDSIPDVSDSFGT-SGPQSSKELEAEMKRLRLELKQTMDMYSSACKQAISAKNQAEQIRQWKMEEDRKVEVVRLSQEAALALAEREKIRAKAALEAAEEARRRAEQDAQRRKDAEMKARLEAEEKERALSALAHNDNRYRKYTIVEIEAATEKFYPLNKIGEGGYGPVYKGHLDHTPVAIKILRPDAVHGMKQFQQEIEVLSCIRHPHMVLLLGACPEHGCLVYEYMDNGSLEDRLYRKNNSRPISWRKRFQIAAEIATALLFLHQNKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPASVADTMTQYYMTSAAGTFCYIDPEYQQTGILTTKSDVYSLGIMLLQIITAKPPMGLAHIVKKAIEKGRFEEILDPVVTDWPVEEALSFAKLPLKCSELSKKDRPNLATVVLPELNRLSELELTLHNDQVFYSSEGMINSYAACPPTPP 706          

Query:    8 GPPQQNTMVAVDRDKNSAYAFRWAVNHLDNPVIIAVHVKHKNLSNQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANN--DIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDL 684
             PPQ  TMVAVD+DKNSA AFRWAVNHLDNPVIIAVHVKHKN S+  TNVFPPDEDDV +IF++LR MC  KA+ MKEAV+DD DVV+GLLEFA RN+IHSIVVGAS KN + S+KK KA    DI T MIK APD+CSVYIISKLK+VSARSAVR +   +   K +PV  S P  +  G +R  +PR+   YEG++E              RERP+S G+ +S+D ID+P+ R RNW SMDER+++ LG +++ NR D  + +S    S+  +S+ELEAEMKRLRLELKQTMDMYSSACKQAISAKNQ +QIR+W++EE+++V  VR+SQEAALA+AE+EKARAKAA+EAAEEA+ +AE EA RR++AE KA  EAEE++R L+ LAQ+D RYR+YT+EEIE+AT++FSPS KIGEGGYGPVFKGHLDHT VAIK+L P+ASQG KQF QE+EVLSCIRHP+MVLLLGACPEHGCLVYEY+DNGSLEDRLFRKN S+P+ W+KRF+I+AEI+TALLFLHQ KPEPIVHRDLKPSNIL+DRNYVSKISDVGLARLVPPSV D VTQYYMTSAAGTFCYIDPEYQQTGILTT+SD+YSLGIMLLQIIT +PPMGL H V+KA+EKG FE++LDP +TDWPVEEALS+AK+AL CA+L KKDRP+LA  VLPE+ RL +L
Sbjct:    5 APPQNVTMVAVDKDKNSANAFRWAVNHLDNPVIIAVHVKHKNFSHHVTNVFPPDEDDVVNIFNSLRGMCTRKAVMMKEAVVDDADVVRGLLEFANRNLIHSIVVGASAKNPLSSLKKLKAYQCQDIPTAMIKSAPDFCSVYIISKLKLVSARSAVRSLSKNLTTPKSIPVPPSPPSPD-GGPLRGQIPRSRAIYEGAAEPMRVIH-------ARERPKSAGNGISIDHIDIPA-RPRNW-SMDEREISGLG-LMDLNRIDSGISESLPVSSSPQSSKELEAEMKRLRLELKQTMDMYSSACKQAISAKNQAEQIRQWKLEEDRRVEVVRMSQEAALAIAEKEKARAKAAMEAAEEARRRAEQEAQRRKDAEEKARVEAEEKERALSTLAQNDTRYRRYTIEEIELATEKFSPSNKIGEGGYGPVFKGHLDHTPVAIKILRPDASQGMKQFNQEIEVLSCIRHPHMVLLLGACPEHGCLVYEYLDNGSLEDRLFRKNSSRPIPWKKRFEISAEIATALLFLHQNKPEPIVHRDLKPSNILVDRNYVSKISDVGLARLVPPSVADTVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGIMLLQIITGKPPMGLAHLVRKAVEKGRFEEVLDPVITDWPVEEALSYAKLALQCAQLSKKDRPNLATEVLPELTRLSEL 672          

Query:   10 PQQNTMVAVDRDKNSAYAFRWAVNHLDNPVIIAVHVKHKNLS-NQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDY 689
            P   TMVAVD+DKNSAYAFRWA+NHLDNPVIIAVHVKHKNL  N GTNV PPDE+D+++IFS LR MC  KA+ +KEAVIDD D+V+GL E+A RN+IHSIVVGAS +N + S KK K   D+ T M+K APDY SVY+ISK KIV ARSA+R M N  +P K   VQA  PY E E G+R+      G         S+D  + V      RPRS GSN S+D I   +SR R+  SMDE+D++ L P+ +  + DMDL DS+G    S ++ E+EAEMKRLRLELKQTMDMYSSACKQAISAKNQ +QIR+W+++EE+ V E RLSQ+AALAMA +EK +A  A E AEEA+ +AE EA +RREAEMKA KE+EE+D+VL ALA+ DNRYR+YT+EEIE ATD+FS SKKIGEGGYGPV+KG LDHT VAIK+L+P+ASQGRKQFQQEVEVL  IRHPNMVLLLGACPE+GCLVYE+M+NGSL+DRLFR+N S PLSW+ RFQI+AEISTALLFLHQTKPEP+VHRDLKP NILLD+NYVSKI+DVGLARLVPPSV D VTQYYMTSAAGTFCYIDPEYQ +G+LT +SD+YS GIMLLQIITA+P MGL HQVK+AIEK  F +ILDPAVTDWPVE+AL FAK+AL CAEL KKDRP LA VVLP + RLRD G+  +
Sbjct:    8 PINATMVAVDKDKNSAYAFRWAINHLDNPVIIAVHVKHKNLHHNGGTNVHPPDEEDMANIFSALRGMCNRKAVEVKEAVIDDIDIVRGLQEYAHRNLIHSIVVGAS-RNPLSSFKKLKGY-DVPTAMLKTAPDYSSVYVISKWKIVQARSAIRQMTNAPVPPKNPLVQAM-PYNESENGIRTPPHHPNGI--------SYDKNNNVS----RRPRSAGSNQSMDHIIEIASRSRH-VSMDEKDISGLMPL-DLTKQDMDLSDSHGYSPKSQSTHEMEAEMKRLRLELKQTMDMYSSACKQAISAKNQAEQIRQWKLKEERMVEESRLSQKAALAMAAQEKLKAIVAWEEAEEARKRAEQEAQKRREAEMKAKKESEEKDQVLNALARSDNRYRRYTIEEIEAATDQFSSSKKIGEGGYGPVYKGKLDHTPVAIKILSPDASQGRKQFQQEVEVLCRIRHPNMVLLLGACPEYGCLVYEHMENGSLDDRLFRRNNSPPLSWRLRFQISAEISTALLFLHQTKPEPLVHRDLKPGNILLDKNYVSKIADVGLARLVPPSVADTVTQYYMTSAAGTFCYIDPEYQSSGMLTPKSDIYSFGIMLLQIITAKPAMGLAHQVKRAIEKDKFSEILDPAVTDWPVEKALEFAKLALDCAELSKKDRPDLATVVLPTLCRLRDFGNASH 671          

Query:   10 PQQNTMVAVDRDKNSAYAFRWAVNHLDNPVIIAVHVKHKNLS-NQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDY 689
            P   TMVAVD+DKNSAYAFRWA+NHLDNPVIIAVHVKHKNL  N GTNV PPDE+D+++IFS LR MC  KA+ +KEAVIDD D+V+GL E+A RN+IHSIVVGAS +N + S KK K   D+ T M+K APDY SVY+ISK KIV ARSA+R M N  +P K   VQA  PY E E G+R+      G         S+D  + V      RPRS GSN S+D I   +SR R+  SMDE+D++ L P+ +  + DMDL DS+G    S ++ E+EAEMKRLRLELKQTMDMYSSACKQAISAKNQ +QIR+W+++EE+ V E RLSQ+AALAMA +EK +A  A E AEEA+ +AE EA +RREAEMKA KE+EE+D+VL ALA+ DNRYR+YT+EEIE ATD+FS SKKIGEGGYGPV+KG LDHT VAIK+L+P+ASQGRKQFQQEVEVL  IRHPNMVLLLGACPE+GCLVYE+M+NGSL+DRLFR+N S PLSW+ RFQI+AEISTALLFLHQTKPEP+VHRDLKP NILLD+NYVSKI+DVGLARLVPPSV D VTQYYMTSAAGTFCYIDPEYQ +G+LT +SD+YS GIMLLQIITA+P MGL HQVK+AIEK  F +ILDPAVTDWPVE+AL FAK+AL CAEL KKDRP LA VVLP + RLRD G+  +
Sbjct:    8 PINATMVAVDKDKNSAYAFRWAINHLDNPVIIAVHVKHKNLHHNGGTNVHPPDEEDMANIFSALRGMCNRKAVEVKEAVIDDIDIVRGLQEYAHRNLIHSIVVGAS-RNPLSSFKKLKGY-DVPTAMLKTAPDYSSVYVISKWKIVQARSAIRQMTNAPVPPKNPLVQAM-PYNESENGIRTPPHHPNGI--------SYDKNNNVS----RRPRSAGSNQSMDHIIEIASRSRH-VSMDEKDISGLMPL-DLTKQDMDLSDSHGYSPKSQSTHEMEAEMKRLRLELKQTMDMYSSACKQAISAKNQAEQIRQWKLKEERMVEESRLSQKAALAMAAQEKLKAIVAWEEAEEARKRAEQEAQKRREAEMKAKKESEEKDQVLNALARSDNRYRRYTIEEIEAATDQFSSSKKIGEGGYGPVYKGKLDHTPVAIKILSPDASQGRKQFQQEVEVLCRIRHPNMVLLLGACPEYGCLVYEHMENGSLDDRLFRRNNSPPLSWRLRFQISAEISTALLFLHQTKPEPLVHRDLKPGNILLDKNYVSKIADVGLARLVPPSVADTVTQYYMTSAAGTFCYIDPEYQSSGMLTPKSDIYSFGIMLLQIITAKPAMGLAHQVKRAIEKDKFSEILDPAVTDWPVEKALEFAKLALDCAELSKKDRPDLATVVLPTLCRLRDFGNASH 671          

Query:   79 KAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSAR----------------------------------------SAVRPMVNQIIPMKILPV---QASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSI--STVKGSTRERPRSTGSNMSLDCIDVPSSRGRNWASMDER-DMAALGPIVESNRSDM---DLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPS-VVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGC-FEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSHRPPT 706
            + + ++  VI+  +V   + E   R+ I  IV+G S+++       F    DI + +  L P++C+VY++SK K+   R                                        S  RP+   +  M+  P    QAS P      G       T      + E+R   SI  S+   ++R  PR        + +   SS  R + +   R   + +G     +R+     ++ D+    S +     L  E+++LR EL+   +MY+ A  +   A  ++ ++ + R+EE  K+ E++L +  A  +AE+EK   + A   AE  + +AE E  +RREAE K+ ++ +E++++   L     +Y+ +  EEI  AT  FS   KIG G YG V+K +L HT   +K+L    +Q  KQFQQE+E+LS IRHP++VLLLGACPE G LVYEYM+NGSLEDRLF+ N S PL W +RF+IA E++ AL+FLH++KP+PI+HRDLKP+NILLD N+VSK+ DVGL+ +V    +    T Y  TS  GT CYIDPEYQ+TG ++++SD+YS G++LLQ++TA+P + LTH V+ A++    F +ILD    +WP+EE    A +AL C EL  KDRP L   +LP +  L+ + +     F+     G S +PPT
Sbjct:  106 RKVAVEVLVIESDNVAAAIAEEVTRDSIDRIVIGGSSRSF------FSRKADICSVISALMPNFCTVYVVSKGKLSCVRPSDSDGNATIREDGSERTNSSSGSSGPTSDSSDVMSSAHDSQSRPLSLPVRRMQHFPAIAGQASVPMETSSVGS----DETRCMSLDAEEARDVSSINRSSTDTTSRWTPRRRDYEERKEAMS-SSSSNREYGNFGTRFSWSGMGVDTTHSRASQQASNMSDALSEQSYTDNQVNLNFEVEKLRAELRHVQEMYAVAQTETFDASRKLGELNQRRLEEAIKLEELKLKEYEARELAEKEKQNFEKARRDAESMRERAEREIAQRREAERKSARDTKEKEKLEGTLGSPQLQYQHFAWEEIMAATSSFSEELKIGMGAYGAVYKCNLHHTTAVVKVLQSAENQLSKQFQQELEILSKIRHPHLVLLLGACPEQGALVYEYMENGSLEDRLFQVNNSPPLPWFERFRIAWEVAAALVFLHKSKPKPIIHRDLKPANILLDHNFVSKVGDVGLSTMVQVDPLSTKFTIYKQTSPVGTLCYIDPEYQRTGRISSKSDIYSFGMILLQLLTAKPAIALTHFVESAMDSNDEFLKILDQKAGNWPIEETRELAALALCCTELRGKDRPDLKDQILPALENLKKVAEKARNSFS-----GVSTQPPT 768          

Query:  284 LEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAI-EKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSH 702
            L  E+++LR ELK   +MY+ A  + + A  ++ ++ + R EE +K+VE++  +E A   A +EK R + A++ AE+ K     EA  RREAE KA ++A E+D++  +L     +Y+ YT EEI  AT  F+ + KIG G YG V+K +L HT  A+K+L+   +Q  KQF QE+E+LS IRHP++VLLLGACPE GCLVYEYMDNGSL+DRL   N + P+ W +RF+IA E+++AL+FLH++KP PI+HRDLKP NILLD N+VSK+ DVGL+ +V    V + T +  TS  GT CYIDPEYQ+TGI++ +SDVYSLG+++LQ+ITA+P + +TH V++AI +   F  ILD     WP+ +    A + L C E+ ++DRP L   ++P + RLR + D      + T S   SH
Sbjct:  359 LNFEIEKLRAELKHVQEMYAMAQTETVGASKKLTELNQRRFEESEKLVELKEKEEVAKDTASKEKQRYEEAMKEAEKVKELMMKEALHRREAEFKAERDAREKDKLQASLVSPGVQYQHYTWEEIAAATSDFAENLKIGIGAYGSVYKCNLHHTTGAVKVLHAGETQLSKQFDQELEILSKIRHPHLVLLLGACPERGCLVYEYMDNGSLDDRLMLVNDTPPIPWFERFRIALEVASALVFLHKSKPRPIIHRDLKPGNILLDHNFVSKLGDVGLSTMVNQDDVSSRTIFKQTSPVGTLCYIDPEYQRTGIISPKSDVYSLGVVILQLITAKPAIAITHMVEEAIGDDAEFMAILDKKAGSWPISDTRELAALGLCCTEMRRRDRPDLKDQIIPALERLRKVADKAQNLLSRTPSGPPSH 778          

Query:  131 IATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPY-------GEFEGGMRSILP------RTGGTYEGSSESRSFDSISTVKGSTRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLIDS------YGTPSTSYTSRELEAEMK--RLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSHRPPT 706
            +   +++ AP+ C VYI+ K +I +   ++ P++N+       P  A++ +         F       LP        G     S+    F+++S     T  +P++  S+ +         R R  + + + + +         +S+++ I S         P TS  S+++E E +  RL+ EL+ T+  Y  AC++  S +N+V  +    + E K+V      +E     A  EK R   A++  E AK     E  +R+ AE+ A++   E+ +V+  L   D+RYRKYT+EEI  AT+ FSP K IGEGGYG V++  LD T  A+K++  +  + +++F +EVEVLS +RHP++VLLLGACPE+GCLVYEY++NGSLE+ +F +    PL W  RF++  E++  L FLH +KPEPIVHRDLKP NILL+RNYVSKI+DVGLA+LV     DNVT Y  +  AGT  YIDPEY +TG +  +SD+Y+ GI++LQ++TAR P G+   V+ A++KG   ++LD +VTDWP+ E    A+I L CAE   +DRP L   V+P + RL +  +      +  K  G + R P+
Sbjct:  145 VPLTVLRYAPETCEVYIVCKDRITT--KSMDPLINREPCTS--PHAAATAHDFLRDWAASFHTLRSPTLPDPRQSTEAGTRRSASARELRFEALSL----TCNKPKTPQSSKASSATTPEIFRRRRGSDIPQLNYSDFDKTCTKPQSNVENIVSEHRDSDRSPPETSRKSKKVEIEEEVERLKNELQSTVFKYKQACEELFSTQNKVKMLSTEYLNESKRVNNAVEKEELQRNTAALEKERYMKAVKEVETAKALLAREFCQRQIAEVNALRTYLEKKKVIDQLLGTDHRYRKYTIEEIVTATEGFSPEKVIGEGGYGKVYQCSLDSTPAAVKVVRLDTPEKKQEFLKEVEVLSQLRHPHVVLLLGACPENGCLVYEYLENGSLEEYIFHRKNKPPLPWFIRFRVIFEVACGLAFLHSSKPEPIVHRDLKPGNILLNRNYVSKIADVGLAKLVTDVAPDNVTMYRNSVLAGTLHYIDPEYHRTGTIRPKSDLYAFGIIILQLLTARNPSGIVPAVENAVKKGTLTEMLDKSVTDWPLAETEELARIGLKCAEFRCRDRPDLKSEVIPVLKRLVETAN------SKVKKEGSNLRAPS 727          

Query:  271 SYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQ---HDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKN------KSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAI--EKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSHRPPT 706
            +Y  P++S +    + E+++L++EL+    MY+ A  + I A  ++  + + R EE  ++  + + +E A  + E E+ R + A   AE  +   E E   R EAE +A +  +E+ R+  AL        +Y K+  EEI  AT  FS   KIG GGYG V++ +L HT VA+K+L+ + S   KQF QE+E+LS IRHP+++LLLGACPE G LVYEYM NGSLE+RL ++       +  PL W +RF+IA EI++AL FLH  +P PIVHRDLKP+NILLDRN VSKI DVGL+++V        T +  T   GTF YIDPEYQ+TG++T  SD+Y+ GI+LLQ++TAR  MGL H ++KA+  + G F +ILD    DWPV+EA     I L CAE+ K+DRP L K +LP + RL+++       F D   + H H  PT
Sbjct:  282 TYSDPTSSSSQIHKDFELEKLKIELRHIKGMYAVAQSEVIDASKKMQDLNQRRSEEATRLKNLTIREEEADEVVEMERERQEDAENEAELVRECIERETEERLEAEARAEEVRKEKQRLEDALEGGPLQRQQYMKFEWEEIVEATSSFSDELKIGVGGYGSVYRCNLHHTTVAVKVLHSDKSSLTKQFHQELEILSKIRHPHLLLLLGACPERGSLVYEYMHNGSLEERLMKRRPNVDTPQPPPLRWFERFRIAWEIASALYFLHTNEPRPIVHRDLKPANILLDRNNVSKIGDVGLSKMVNLDPSHASTVFNETGPVGTFFYIDPEYQRTGVVTPESDIYAFGIILLQLVTARSAMGLAHSIEKALRDQTGKFTEILDKTAGDWPVKEAKEMVMIGLRCAEMRKRDRPDLGKEILPVLERLKEVASIARNMFADNLID-HHHNAPT 727          

Query:  287 EMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDN-RYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPS--VVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFE---QILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGD 686
            E+ +LR EL+   +MY+ A  + + A  +++++         K  E+ L +     +A++E  +         E K + E EA +RREAEMKA  EA+E++++  +       +Y+++T EEI  AT  FS   KIG G YG V+K +L HT  A+K+L+   S   KQF QE+E+LS IRHP++VLLLGACP+HG LVYEYM+NGSLEDRLF+ N S+P+ W  R +IA E+++AL+FLH++KP PI+HRDLKP+NILL+ N+VSK+ DVGL+ ++  +  +    T Y  TS  GT CYIDPEYQ+TG ++ +SDVY+ G+++LQ++T +  M LT+ V+ A+E    +   QILD    +WP+EE    A +AL C EL  KDRP L   +LP +  L+ + D
Sbjct:  348 EISKLRAELRHAHEMYAVAQVETLDASRKLNEL---------KFEELTLLEHETKGIAKKETEKF--------EQKRREEREAAQRREAEMKATHEAKEKEKLEESSLVAPKLQYQEFTWEEIINATSSFSEDLKIGMGAYGDVYKCNLHHTIAAVKVLHSAESSLSKQFDQELEILSKIRHPHLVLLLGACPDHGALVYEYMENGSLEDRLFQVNDSQPIPWFVRLRIAWEVASALVFLHKSKPTPIIHRDLKPANILLNHNFVSKVGDVGLSTMIQAADPLSTKFTMYKQTSPVGTLCYIDPEYQRTGRISPKSDVYAFGMIILQLLTGQQAMALTYTVETAMENNNDDELIQILDEKAGNWPIEETRQLAALALQCTELRSKDRPDLEDQILPVLESLKKVAD 736          

Query:   12 QNTMVAVDRD-KNSAYAFRWAVNHLDNPVIIAVHVKHKN--------------LSNQGTNVFPPDEDDVSH-IFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNH----MPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGS----SESRSFDSISTV---KGSTRERPRSTGSNMSLDCIDVPS--SRGRNWASMDERDMAALGPIVESNRSDMDLIDSYGTPSTSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWR------VEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEA-HRRREAEMKAMKEAE--------ERDRVL-----------TALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVV 674
            +   VAVD+    S     WA+ +     I  +HV   +              +  +   VF   E +  H I  +   +CQ + +  ++  I+   +  G+++      I  +V+GA+   H    M  +K  K     A  + + AP  C ++   K  ++  R A          M     + +SP         S L +T  T E      S  +S DS+  +     ST +  R +  +++ D  +  S  S     A++     ++     +      ++     T     + +E  AE  R +   K  +D    A KQ+ SA ++  +++R +       +E+++ + ++  QE  + M E + A A+ A+  ++ AK    +E  +++ +  +K +++          ERDR L           T+  Q    +  ++  EIE AT+ F  + KIGEGGYG ++ G L HT VAIK+LNP +SQG  ++QQEV+VLS +RHPN++ L+GACPE   LVYEY+  GSLEDRL  K+ S PLSWQ R +IA EI  AL+FLH  K   +VH DLKP+NILLD N VSK+SD G   L+ P    N ++   T   GT  Y+DPE   +G LT +SDVYS GI+LL+++T RP + ++++VK A++ G    +LDP   DWP  +A   A++AL C E   ++RP L   V
Sbjct:   45 EKIFVAVDKHVAKSKSTLIWALQNTGGKKICLIHVHQPSQMIPLMGAKFPVGAVKEEEVRVFREKEREKVHMILDDYLRICQQRGVRAEKMFIEMESIENGIVQLISELGIRKLVMGAAADRHYSRRMTDLKSRK-----AIFVRREAPTLCQIWFTCKGYLIHTREAT---------MDDTESEYASPRPSISA---SDLLQTFSTPESEHQHISRVQSTDSVQQLVSNGSSTEQSGRVSDGSLNTDEEERESDGSEVTGSATVMSSGHSSPSSFPDGVDDSFNVKIRKATSEAHSSKQEAFAETLRRQKAEKNALDAIRRA-KQSESAYSE--ELKRRKDTEIAVAKEKERFITIKNEQE--VIMEELQSAMAQKAMLESQIAKSDGTMEKLNQKLDIAVKLLQKLRDEREELQTERDRALREAEELRSHAETSTLQLPQYFTDFSFSEIEEATNHFDSTLKIGEGGYGSIYVGLLRHTQVAIKMLNPNSSQGPVEYQQEVDVLSKMRHPNIITLIGACPEGWSLVYEYLPGGSLEDRLTCKDNSPPLSWQNRVRIATEICAALVFLHSNKAHSLVHGDLKPANILLDSNLVSKLSDFGTCSLLHP----NGSKSVRTDVTGTVAYLDPEASSSGELTPKSDVYSFGIILLRLLTGRPALRISNEVKYALDNGTLNDLLDPLAGDWPFVQAEQLARLALRCCETVSENRPDLGTEV 736          

Query:  379 AMKEAEE----RDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRD 683
            A++E EE    R ++L+ L      + +++  E+E AT+ FS S KIGEGG+G V+KG L +  VAIK+L P++ QG+ QF+QEV +LS +RHP++V LLGAC E   LVYE++ NGSLED L   +K + L+WQ R +I AEI +AL+FLH+ KP P+VH DLKP+NILL  N VSK+SD G++RL+  S  +N T Y      GT  Y+DPE+  TG LT +SDVYS GI++L+++T +PP+G+ + V+ A+EKG    ++D +V +WP       A +AL C EL ++ RP L+  V   +  +RD
Sbjct:  407 AVREVEELRQKRGQMLSVLVT--AMHCEFSSSEVESATENFSNSLKIGEGGFGCVYKGILRNMTVAIKVLRPDSLQGQSQFEQEVSILSRVRHPHLVTLLGACSESSTLVYEFLPNGSLEDFLMCSDKRQTLTWQARIRIIAEICSALIFLHKNKPHPVVHGDLKPANILLGVNLVSKLSDFGISRLLIQSSTNNTTLYRTMHPVGTPLYMDPEFLSTGELTPQSDVYSFGIVVLRLLTGKPPVGIKNIVEDAMEKGDLNSVIDTSVGEWPHLHIEQLAYLALRCTELSRRCRPDLSGEVWAIVEAIRD 713          

Query:  403 YTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLR 682
            Y+  EI  AT+ F PS K+GEG YG V+KG+L H  VA+K+L    S    +F++ VE+LS +RHPN+V L+GACPE   L+Y+Y+ NGSLED    +N    LSW+ R +IA+EI +ALLFLH   P  I+H +LKPS ILLD N V+KI+D G+++L+P   +D               ++DP Y  +  +T  SD+Y+ GI+LLQ++T RP  G+   VK A+E      +LD +  DWPV      A +A+ C +    +RP LA VVL  I+R++
Sbjct:  448 YSFMEINEATNEFDPSWKLGEGKYGSVYKGNLQHLQVAVKMLPSYGSLNHFEFERRVEILSRVRHPNLVTLMGACPESRSLIYQYIPNGSLEDCFSSENNVPALSWESRIRIASEICSALLFLHSNIP-CIIHGNLKPSKILLDSNLVTKINDYGISQLIPIDGLDKSDP-----------HVDPHYFVSREMTLESDIYAFGIILLQLLTRRPVSGILRDVKCALENDNISAVLDNSAGDWPVARGKKLANVAIRCCKKNPMNRPDLA-VVLRFIDRMK 714          

Query:  308 QAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARL------VPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVV 674
            Q +  +   +++R+  + EE+ V    L  +A   + ++EKA     + A ++ K       H R  A  +  +  ++   ++   ++ D          +E AT+ F  ++++G+  YG  +KG + +  V IKL     S  +K FQQEV +L   RHPN++  +G C E   LVYE++ NG+LEDR+   N S PLSW  R QI  EI  ALLFLH  K   +VH DL+P NIL+D NY SKI + G++ L       PP++   +             Y+DPE+  TG LTT SDVYSLG+++L+++T  PP+ L+ +V +A+       ++D +  DWP  EA   A I L C  + +K RP L   V
Sbjct:   77 QHVCDRKTYEEVRKVHILEEEIVT---LKHQADTYLVQKEKA-----VTAYDQLK-------HERDNAVQQVNELRDQSTHIILDFSRKD----------MEQATEHFKNAREVGDTEYGHTYKGMIHNMKVLIKL-----SSSQKLFQQEVSILRQWRHPNIITFIGVCSEVSALVYEWLPNGNLEDRIICTNNSAPLSWYNRTQIIGEICCALLFLHSNKSTALVHGDLRPCNILIDANYRSKICNFGMSNLFLQLGTFPPNLTARLP------------YMDPEFNTTGELTTLSDVYSLGVIILRLLTGMPPLTLSEKVAEALGSDSLHLLIDKSAGDWPYIEAKQLALIGLSCTGMTRKKRPDLLNEV 407          

Query:  403 YTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHT--------AVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPE--HGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVK----------KAIEKGCFEQILDPAVTD-WPVEEALSFAKIALGCAELCKKDRPSLAKVV 674
            +T+ E+E  T  F P   +GEGG+G V+KG++D           VA+K+LN E  QG +++  EV  L  +RHPN+V L+G C E  H  LVYE+M  GSLE+ LFRK  + PLSW +R  IA   +  L FLH  +  P+++RD K SNILLD +Y +K+SD GLA+  P     +V+    T   GT+ Y  PEY  TG LT RSDVYS G++LL+++T R  +  T   K          K  +K    QI+DP + + + V  A     +A  C     K RP ++ VV
Sbjct:   57 FTLFELETITKSFRPDYILGEGGFGTVYKGYIDDNLRVGLKSLPVAVKVLNKEGLQGHREWLTEVNFLGQLRHPNLVKLIGYCCEDDHRLLVYEFMLRGSLENHLFRKT-TAPLSWSRRMMIALGAAKGLAFLHNAE-RPVIYRDFKTSNILLDSDYTAKLSDFGLAKAGPQGDETHVS----TRVMGTYGYAAPEYVMTGHLTARSDVYSFGVVLLEMLTGRKSVDKTRPSKEQNLVDWARPKLNDKRKLLQIIDPRLENQYSVRAAQKACSLAYYCLSQNPKARPLMSDVV 343          

Query:   10 PQQNTMVAVDRDKNSAYAFRWAVNHL----DNPVIIAVHVKHKNLSNQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKL-KIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRST-------GSNMSLDCIDVP------SSRGRNWASM-----------DERD--MAALGPIVESNRSDMDLIDSYGTPSTS-----YTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGD 686
            P  +T+VA+D++K+S+YA RWAV+HL     NPV+I VHV+ KN SN G N+   + DD++ +F   R  C  K I+M E V+DD DV K +L++   N+++++V+GASTKN       F   +++ ++++K  PD+CSVY+ISK  K+ S+R A RP+ N + P ++                    P +G   +  S+S   D I  V+ S R +P  T         N +      P       + G N A+            DE D     +G +  S+++ MD    +G  S+S      +++++EAEM+RL+LELKQTMDMYSSACK+A++AK + +++ +W++EE +K  + RLS+EAALA+AE EKA+ + A+EAAE+A+  AELE  RR++AEMKA+ E +++DR ++ALA +D RYRKY++EEIE AT+RF+  +KIGEGGYGPV+ G LDHT VAIK+L P+A+QG+KQFQQEVEVL  IRHP+MVLLLGACPE+GCLVYE+M+NGSLEDRLFR   S PLSW+KRF+IAAEI+TAL FLHQ KPEP+VHRDLKP+NILLD+NYVSKISDVGLARLVP S+ D+VTQ++MTSAAGTFCYIDPEYQQTG+LTT+SDVYSLGI+LLQIIT RPPMGL HQV +AI KG F+++LDP V DWPV+EA SFA +AL CAEL K+DRP L K V+P + RL++ G+
Sbjct:   16 PVNSTVVAIDKEKHSSYAVRWAVDHLLNMIHNPVMILVHVRTKN-SNHGANL---NNDDLNQLFIPYRGYCARKGISMTEVVLDDSDVAKTILDYVNNNLVNNLVLGASTKNTFARSFMFSKPHEVQSSIMKSTPDFCSVYVISKGGKVQSSRPAQRPITNTLAPPRV--------------------PSSGFLIQSLSDSEQ-DLIPRVQRSARNKPNETTYPHNRAAFNTTQKGYKSPINGSMDFNNGFNQAAFQRNPTLQSSFSDESDGGFGVMGSVDLSSQNSMDFY--HGASSSSEESIPQSTKDIEAEMRRLKLELKQTMDMYSSACKEALTAKRKANELNQWKIEEARKFEKARLSEEAALAVAEIEKAKCRTAVEAAEKAQRMAELEGQRRKQAEMKAVSEEKDKDRAVSALAHNDVRYRKYSIEEIEEATERFANHRKIGEGGYGPVYNGELDHTPVAIKVLRPDAAQGKKQFQQEVEVLCSIRHPHMVLLLGACPEYGCLVYEFMENGSLEDRLFRTGNSPPLSWRKRFEIAAEIATALSFLHQAKPEPLVHRDLKPANILLDKNYVSKISDVGLARLVPASIADSVTQFHMTSAAGTFCYIDPEYQQTGMLTTKSDVYSLGILLLQIITGRPPMGLAHQVSRAISKGTFKEMLDPVVPDWPVQEAQSFATLALKCAELRKRDRPDLGKEVVPHLIRLKNFGN 701          

Query:    1 MSLPPPTGPPQ---QNTMVAVDRDKNSAYAFRWAVNHLDNPVI----IAVHVKHKNLSNQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKIL--------PVQASSPYGEFEGGMRSILP-RTGGTYEGSSESRSFDSISTVKGS---TRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPI--VESNRSDMDLIDSYGTP--STSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLG 685
            M+ P P+        +T+VA+D+DKNS +A RWAV+HL N +I    I +HV+ KN SN G N+   D+ +++ +F   R  C  K I+M E ++DD DV K +L++   N++ ++V+G+S+K+      KF  ++D+A++++K  P++CSVY+ISK K+ S+R+A RP+ N ++P ++         P    SP  +  G  R+ +P R     +G    R    I T  GS     E  +  G           +S GR+  S +  D+ ++  +  ++ +  + D++   G+   S S ++R++EAEMKRL++ELKQTMDMYSSACK+A++AK + +++ +W++EE ++  E R ++EAALA+AE EKA+ +AALEAAE+A+  AELE  RR++AEMKA +E++E+DR L+AL Q+D RYRKY+++EIEVAT+RF+ ++KIGEGGYGPV+ G LDHT VAIK+L P+A+QG+KQFQQEVEVLS IRHP+MVLLLGACPE+GCLVYE+MDNGSLEDRLFR+  S PLSW+KRFQIAAEI+TAL FLHQ KPEP+VHRDLKP+NILLD+NYVSKISDVGLARLVP SV + VTQY+MTSAAGTFCYIDPEYQQTG LTT+SD++SLGIMLLQIITA+ PMGL H V +AI+KG F+ +LDP V DWPVEEAL+FAK+ L CAEL K+DRP L K ++PE+ RLR+LG
Sbjct:    1 MARPHPSDDSHTLVNSTVVAIDKDKNSHFAVRWAVDHLFNMIINSKMILLHVRLKN-SNHGGNI---DDSELNQLFVPYRGYCARKGISMMEVILDDTDVSKAVLDYVNNNLVTNLVLGSSSKSPFARSLKFTKSHDVASSVLKSTPEFCSVYVISKGKVHSSRTAQRPITNTLVPPRVPSSTFHLPDPDHDRSPRSQRNG--RNTVPERYSHENKGFKPVREMHKIPT-NGSLDFNYEFRQGKGQR---------NSTGRSSFSDESSDVGSMMMMGSIDLSAENFDMVGGSGSSDESASQSTRDIEAEMKRLKIELKQTMDMYSSACKEALNAKKKANELNQWKMEEARRFEEARNAEEAALAVAEMEKAKCRAALEAAEKAQRMAELEGQRRKQAEMKARRESQEKDRALSALVQNDVRYRKYSIDEIEVATERFANNRKIGEGGYGPVYHGTLDHTPVAIKVLRPDAAQGKKQFQQEVEVLSSIRHPHMVLLLGACPEYGCLVYEFMDNGSLEDRLFRRGNSPPLSWRKRFQIAAEIATALSFLHQAKPEPLVHRDLKPANILLDKNYVSKISDVGLARLVPASVANTVTQYHMTSAAGTFCYIDPEYQQTGKLTTKSDIFSLGIMLLQIITAKSPMGLAHHVSRAIDKGTFKDMLDPVVPDWPVEEALNFAKLCLRCAELRKRDRPDLGKEIVPELLRLRNLG 692          

Query:   10 PQQNTMVAVDRDKNSAYAFRWAVNHL----DNPVIIAVHVKHKNLSNQGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKL-KIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSISTVKGSTRERPRST-------GSNMSLDCIDVP------SSRGRNWASM-----------DERD--MAALGPIVESNRSDMDLIDSYGTPSTS-----YTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGD 686
            P  +T+VA+D++K+S+YA RWAV+HL     NPV+I VHV+ KN SN G N+   + DD++ +F   R  C  K +     V+DD DV K +L++   N+++++V+GASTKN       F   +++ ++++K  PD+CSVY+ISK  K+ S+R A RP+ N + P ++                    P +G   +  S+S   D I  V+ S R +P  T         N +      P       + G N A+            DE D     +G +  S+++ MD    +G  S+S      +++++EAEM+RL+LELKQTMDMYSSACK+A++AK + +++ +W++EE +K  + RLS+EAALA+AE EKA+ + A+EAAE+A+  AELE  RR++AEMKA+ E +++DR ++ALA +D RYRKY++EEIE AT+RF+  +KIGEGGYGPV+ G LDHT VAIK+L P+A+QG+KQFQQEVEVL  IRHP+MVLLLGACPE+GCLVYE+M+NGSLEDRLFR   S PLSW+KRF+IAAEI+TAL FLHQ KPEP+VHRDLKP+NILLD+NYVSKISDVGLARLVP S+ D+VTQ++MTSAAGTFCYIDPEYQQTG+LTT+SDVYSLGI+LLQIIT RPPMGL HQV +AI KG F+++LDP V DWPV+EA SFA +AL CAEL K+DRP L K V+P + RL++ G+
Sbjct:   16 PVNSTVVAIDKEKHSSYAVRWAVDHLLNMIHNPVMILVHVRTKN-SNHGANL---NNDDLNQLFIPYRGYCARKGV-----VLDDSDVAKTILDYVNNNLVNNLVLGASTKNTFARSFMFSKPHEVQSSIMKSTPDFCSVYVISKGGKVQSSRPAQRPITNTLAPPRV--------------------PSSGFLIQSLSDSEQ-DLIPRVQRSARNKPNETTYPHNRAAFNTTQKGYKSPINGSMDFNNGFNQAAFQRNPTLQSSFSDESDGGFGVMGSVDLSSQNSMDFY--HGASSSSEESIPQSTKDIEAEMRRLKLELKQTMDMYSSACKEALTAKRKANELNQWKIEEARKFEKARLSEEAALAVAEIEKAKCRTAVEAAEKAQRMAELEGQRRKQAEMKAVSEEKDKDRAVSALAHNDVRYRKYSIEEIEEATERFANHRKIGEGGYGPVYNGELDHTPVAIKVLRPDAAQGKKQFQQEVEVLCSIRHPHMVLLLGACPEYGCLVYEFMENGSLEDRLFRTGNSPPLSWRKRFEIAAEIATALSFLHQAKPEPLVHRDLKPANILLDKNYVSKISDVGLARLVPASIADSVTQFHMTSAAGTFCYIDPEYQQTGMLTTKSDVYSLGILLLQIITGRPPMGLAHQVSRAISKGTFKEMLDPVVPDWPVQEAQSFATLALKCAELRKRDRPDLGKEVVPHLIRLKNFGN 696          

Query:   83 MKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKIL--------PVQASSPYGEFEGGMRSILP-RTGGTYEGSSESRSFDSISTVKGS---TRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPI--VESNRSDMDLIDSYGTP--STSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLG 685
            M E ++DD DV K +L++   N++ ++V+G+S+K+      KF  ++D+A++++K  P++CSVY+ISK K+ S+R+A RP+ N ++P ++         P    SP  +  G  R+ +P R     +G    R    I T  GS     E  +  G           +S GR+  S +  D+ ++  +  ++ +  + D++   G+   S S ++R++EAEMKRL++ELKQTMDMYSSACK+A++AK + +++ +W++EE ++  E R ++EAALA+AE EKA+ +AALEAAE+A+  AELE  RR++AEMKA +E++E+DR L+AL Q+D RYRKY+++EIEVAT+RF+ ++KIGEGGYGPV+ G LDHT VAIK+L P+A+QG+KQFQQEVEVLS IRHP+MVLLLGACPE+GCLVYE+MDNGSLEDRLFR+  S PLSW+KRFQIAAEI+TAL FLHQ KPEP+VHRDLKP+NILLD+NYVSKISDVGLARLVP SV + VTQY+MTSAAGTFCYIDPEYQQTG LTT+SD++SLGIMLLQIITA+ PMGL H V +AI+KG F+ +LDP V DWPVEEAL+FAK+ L CAEL K+DRP L K ++PE+ RLR+LG
Sbjct:    1 MMEVILDDTDVSKAVLDYVNNNLVTNLVLGSSSKSPFARSLKFTKSHDVASSVLKSTPEFCSVYVISKGKVHSSRTAQRPITNTLVPPRVPSSTFHLPDPDHDRSPRSQRNG--RNTVPERYSHENKGFKPVREMHKIPT-NGSLDFNYEFRQGKGQR---------NSTGRSSFSDESSDVGSMMMMGSIDLSAENFDMVGGSGSSDESASQSTRDIEAEMKRLKIELKQTMDMYSSACKEALNAKKKANELNQWKMEEARRFEEARNAEEAALAVAEMEKAKCRAALEAAEKAQRMAELEGQRRKQAEMKARRESQEKDRALSALVQNDVRYRKYSIDEIEVATERFANNRKIGEGGYGPVYHGTLDHTPVAIKVLRPDAAQGKKQFQQEVEVLSSIRHPHMVLLLGACPEYGCLVYEFMDNGSLEDRLFRRGNSPPLSWRKRFQIAAEIATALSFLHQAKPEPLVHRDLKPANILLDKNYVSKISDVGLARLVPASVANTVTQYHMTSAAGTFCYIDPEYQQTGKLTTKSDIFSLGIMLLQIITAKSPMGLAHHVSRAIDKGTFKDMLDPVVPDWPVEEALNFAKLCLRCAELRKRDRPDLGKEIVPELLRLRNLG 607          

Query:   16 VAVDRDKNSAYAFRWAVNHL--DNPVIIAVHVKHKN--LSN------------QGTNVFPPDEDDVS-HIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVR------PMVNQIIPMKILPVQA--SSPYGEFEGGMRSILPRTGGTYEGSS--------------ESRSFDSISTVKGSTRERPRST--GSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLIDS------YG-------TP---------STSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGD 686
            VA+D+DK+S +A +WAV++L      +I VHVK +   L+N            Q +++   D + +S  IF   R  C  K I  ++ ++++ DV K L+E+  +  I  +VVG+S+K       +F    DI  ++ K APD+C+VYIISK KI + RSA R      P+ + + P  + P Q   S+         RS       + E                 +S SF S  T +G+ R     T   S++S      PS   R + S+ + +  +  P   SN SDMD   S      YG       +P         S S +  ++EAEM+RL+LELKQTM+MYS+ACK+A++AK +  +++RW++EEE+K+ E R ++EAALA+AE+EKA++KAA+EAAE A+  AELEA +R  AEMKA+KE+EE+ + LTALA  D RYRKY++E+IE+AT+ F+   KIGEGGYGPV+K +LDHT VA+K+L P+A+QGR QFQQEVEVLSCIRHPNMVLLLGACPE GCLVYE+M NGSLEDRLFR   S PLSWQ RF+IAAEI T LLFLHQ KPEP+VHRDLKP NILLDRN+VSKISDVGLARLVPP+V D VTQY MTS AGTFCYIDPEYQQTG+L  +SD+YSLGIM LQ+ITA+PPMGLTH V++A+EKG    +LDP V+DWP+E+   FAK+AL CAEL +KDRP LAKV+LPE+NRLR L D
Sbjct:   22 VAIDKDKSSQHALKWAVDNLLQRGQSVILVHVKLRPSPLNNSASLHASSAKLSQDSSLVCRDPEGISKEIFLPFRCFCTRKDIQCQDVLLEESDVAKALVEYVNQAAIEVLVVGSSSKG---GFLRFNKPTDIPGSITKNAPDFCTVYIISKGKIQTMRSASRSAPMTAPLRSSVQPPSLKPPQPMPSTSANSLRADRRSFESNQRRSVEDQQRRSMEDQQRRSIDDQSESFRSPFTRRGNGRSYGDLTVPESDISFISSGRPSI-DRIFPSLYDNNDPSRTPPRLSNFSDMDYSSSLDQSSNYGRRSVDMNSPTDFESERFSSASQSIDDVEAEMRRLKLELKQTMEMYSTACKEALTAKQKATELQRWKLEEERKLEEARNAEEAALAIAEKEKAKSKAAMEAAEAAQRIAELEAKKRVNAEMKALKESEEKTKALTALANSDVRYRKYSIEDIELATEFFAEKYKIGEGGYGPVYKCYLDHTPVAVKVLRPDAAQGRSQFQQEVEVLSCIRHPNMVLLLGACPECGCLVYEFMANGSLEDRLFRLGNSPPLSWQMRFRIAAEIGTGLLFLHQAKPEPLVHRDLKPGNILLDRNFVSKISDVGLARLVPPTVADTVTQYRMTSTAGTFCYIDPEYQQTGMLGVKSDIYSLGIMFLQLITAKPPMGLTHYVERALEKGTLVDLLDPVVSDWPMEDTEEFAKLALKCAELRRKDRPDLAKVILPELNRLRTLAD 751          

Query:    8 GPPQQNTMVAVDRDKNSAYAFRWAVNHLD--NPVIIAVHVKHKNLSN----QGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVR-----PMV------NQIIPMKILPVQASSPYGEFEGGMRSI---LPRTG------------GTYEGSSESRSFDSISTVKGS-----TRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAA--LGPIVESNRSDMD----LIDSYGTPSTSYTSREL---EAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHD-NRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSHRP 704
            G    +  +A+D+DK+S  A +W + +L      +  +HV  K+ S+    +G       E     +F +    C  K I   + V++D D VK ++E+   + I ++V+GA ++N    +++FK   D+ T++ K APD+C+VY+ISK KI S R+A R     P V      ++ I ++     A++P      G RSI   + R G            G +  S    SF S S  + S     +  RP    S+ + D  +  S+R    ++  E+ + +  LG I  ++ S ++    + D  G  S S++S+ L   EA+MKRLRLELKQTMDMYSSAC++A++A+N+  ++++ R EEE+++ E+++++E A+++ E E+A+AK ALEAAE A   AE+EA RR  AEMK +KE++       + ++H   RYRKY+++EIE  T  F+ S+K+GEGGYGPVF+GHLDHT+VA+K+L P+A+QGR QF +EVEVLSCIRHPNMVLLLGACPE+G LVYEYM  GSL+DRLFR+  + P+SWQ RF+IAAEI+T LLFLHQTKPEPIVHRDLKP N+LLD NYVSKISDVGLARLV P+V +NVTQY +TSAAGTFCYIDPEYQQTG+L  +SDVYSLGIMLLQ++TA+ PMGL + V++AIE+G  + +LDPAV DWP+EEALS AK++L CAEL +KDRP L K V+PE++RLR++G+ + LD       G S  P
Sbjct:   12 GTRNGSVAIAIDKDKSSQNAIKWTLENLATRGQTLALIHVLPKSQSSLDIEEGITHKQQMEKQTKDLFVSFHCYCSRKEIHCLDVVLEDVDKVKAIVEYVTVSAIENLVLGAPSRNSF--MRRFK--TDLPTSVSKAAPDFCNVYVISKGKISSLRNASRLAPYHPSVLSEVDDHETIAIERKHKTANTP--ALPKGRRSIDSDVTRLGLPKPPHGHMKLMGDFSDSESEFSFISASQQESSDLSFISSGRPSVDRSSFTYDLPE--SARTSRMSTSSEQSIGSHRLG-IKFTDLSYLNGSSSVSDESGRTSCSFSSQSLNDVEAQMKRLRLELKQTMDMYSSACREALTARNEATELQKLRTEEERRLEELKMTEETAMSIVENERAKAKTALEAAEAANRLAEVEAKRRVHAEMKVLKESD-------SFSRHSIVRYRKYSVQEIEEGTANFAESRKVGEGGYGPVFRGHLDHTSVAVKVLRPDAAQGRSQFHKEVEVLSCIRHPNMVLLLGACPEYGILVYEYMARGSLDDRLFRRGNTPPISWQLRFRIAAEIATGLLFLHQTKPEPIVHRDLKPGNVLLDHNYVSKISDVGLARLV-PAVAENVTQYRVTSAAGTFCYIDPEYQQTGMLGVKSDVYSLGIMLLQLLTAKQPMGLAYYVEQAIEEGTLKDMLDPAVPDWPLEEALSLAKLSLQCAELRRKDRPDLGKEVMPELSRLREIGE-ESLDSVYYAGQGRSSHP 737          

Query:    8 GPPQQNTMVAVDRDKNSAYAFRWAVNHLD--NPVIIAVHVKHKNLSN----QGTNVFPPDEDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVR-----PMV------NQIIPMKILPVQASSPYGEFEGGMRSI---LPRTG------------GTYEGSSESRSFDSISTVKGS-----TRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAA--LGPIVESNRSDMD----LIDSYGTPSTSYTSREL---EAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHD-NRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGDTDYLDFTDTKSNGHSHRP 704
            G    +  +A+D+DK+S  A +W + +L      +  +HV  K+ S+    +G       E     +F +    C  K I   + V++D D VK ++E+   + I ++V+GA ++N    +++FK   D+ T++ K APD+C+VY+ISK KI S R+A R     P V      ++ I ++     A++P      G RSI   + R G            G +  S    SF S S  + S     +  RP    S+ + D  +  S+R    ++  E+ + +  LG I  ++ S ++    + D  G  S S++S+ L   EA+MKRLRLELKQTMDMYSSAC++A++A+N+  ++++ R EEE+++ E+++++E A+++ E E+A+AK ALEAAE A   AE+EA RR  AEMK +KE++       + ++H   RYRKY+++EIE  T  F+ S+K+GEGGYGPVF+GHLDHT+VA+K+L P+A+QGR QF +EVEVLSCIRHPNMVLLLGACPE+G LVYEYM  GSL+DRLFR+  + P+SWQ RF+IAAEI+T LLFLHQTKPEPIVHRDLKP N+LLD NYVSKISDVGLARLV P+V +NVTQY +TSAAGTFCYIDPEYQQTG+L  +SDVYSLGIMLLQ++TA+ PMGL + V++AIE+G  + +LDPAV DWP+EEALS AK++L CAEL +KDRP L K V+PE++RLR++G+ + LD       G S  P
Sbjct:   12 GTRNGSVAIAIDKDKSSQNAIKWTLENLATRGQTLALIHVLPKSQSSLDIEEGITHKQQMEKQTKDLFVSFHCYCSRKEIHCLDVVLEDVDKVKAIVEYVTVSAIENLVLGAPSRNSF--MRRFK--TDLPTSVSKAAPDFCNVYVISKGKISSLRNASRLAPYHPSVLSEVDDHETIAIERKHKTANTP--ALPKGRRSIDSDVTRLGLPKPPHGHMKLMGDFSDSESEFSFISASQQESSDLSFISSGRPSVDRSSFTYDLPE--SARTSRMSTSSEQSIGSHRLG-IKFTDLSYLNGSSSVSDESGRTSCSFSSQSLNDVEAQMKRLRLELKQTMDMYSSACREALTARNEATELQKLRTEEERRLEELKMTEETAMSIVENERAKAKTALEAAEAANRLAEVEAKRRVHAEMKVLKESD-------SFSRHSIVRYRKYSVQEIEEGTANFAESRKVGEGGYGPVFRGHLDHTSVAVKVLRPDAAQGRSQFHKEVEVLSCIRHPNMVLLLGACPEYGILVYEYMARGSLDDRLFRRGNTPPISWQLRFRIAAEIATGLLFLHQTKPEPIVHRDLKPGNVLLDHNYVSKISDVGLARLV-PAVAENVTQYRVTSAAGTFCYIDPEYQQTGMLGVKSDVYSLGIMLLQLLTAKQPMGLAYYVEQAIEEGTLKDMLDPAVPDWPLEEALSLAKLSLQCAELRRKDRPDLGKEVMPELSRLREIGE-ESLDSVYYAGQGRSSHP 737          

Query:   12 QNTMVAVDRDKNSAYAFRWAVNHLDNP--VIIAVHVKHK-NLSNQGTNVFPPDE--DDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSISTVKGST--------RERPRST------GSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDM--------DLIDSYGTPST--SYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGD 686
            ++  +A+DRDK S  A +WAV++L  P   +  +HVK K  L+N GT    P++  DDV  +F   R  C  K I  +E V+++ D  +G++E+ + N I  +V+GAS    +  +K+ KA  D+   +IK AP++C+VY ISK KI S RSA         P  +  ++   P         +  PR           R   S+ +++           +E  + T       S++S    D PS    +W   +  + A      E    D+              G  S+   Y+  ++E+EM+RL+LELK TMDMY+SACK+AI+AK    ++ +W+ E + K+ E  L++EAA+A+AE EKA+++AA+EA E A   AE EA +R++ E  A++E E  ++ + AL   +  YRKYT+EEIE  T +FS S KIGEG YG V+KG LD+T VAIK++ P+A+QGR QFQQEVEVL+CIRHPNMVLLLGAC E+GCLVYEYM NGSL+D L R+  S  LSWQ RF+IAAEI+T+L FLHQ KPEP+VHRDLKP+NILLD++ VSKISDVGLARLVPP++ D  T Y MTS AGT CYIDPEYQQTG+L T+SD+YS GI+LLQI+TA+ PMGLT+QV+KAIE+G F +ILDP VTDWP+EEAL  AKI L CAEL +KDRP L  VVLP + RL +L +
Sbjct:   12 ESVAIAIDRDKGSQAALKWAVDNLLTPGETLTLIHVKVKQTLANNGTQ---PNKSGDDVKELFLPFRCFCTRKDINCEEVVLENVDAAEGIIEYVQENAIDILVLGAS---KITLLKRLKAV-DVTNAVIKGAPNFCTVYAISKGKISSVRSATSS------PPPLCTIRPQLPARSSNANNNNFSPRA---------QRRLQSVQSIQDEIEIKSPYLRKEYDQGTYQALVSDSDLSFVSSDRPS---MDWFEDNRSNYATSSSSSEKQSIDLCSSYSAFSTSSQESGRLSSLSMYSQDDVESEMRRLKLELKYTMDMYNSACKEAIAAKKTTIELHKWKEERKHKLEEAILAKEAAMAIAENEKAKSRAAMEALEAAHRMAETEAQKRKQIETAALREVEHENKAMHALPHSNRMYRKYTIEEIEQGTTKFSDSHKIGEGSYGTVYKGTLDYTPVAIKVVRPDATQGRSQFQQEVEVLTCIRHPNMVLLLGACAEYGCLVYEYMSNGSLDDCLLRRGNSPVLSWQLRFRIAAEIATSLNFLHQLKPEPLVHRDLKPANILLDQHMVSKISDVGLARLVPPTIDDIATHYRMTSTAGTLCYIDPEYQQTGMLGTKSDIYSFGIVLLQILTAKTPMGLTNQVEKAIEEGNFAKILDPLVTDWPIEEALILAKIGLQCAELRRKDRPDLGTVVLPGLKRLMNLAE 690          

Query:   16 VAVDRDKNSAYAFRWAVNHL--DNPVIIAVHVKHK----------NLSNQGTNVFPPD--------EDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRPMVNQIIPMKILPVQASSPYGEFEGGMRSILPRTGGTYEGSSESRSFDSI---STVKGSTRERP---------RSTG------SNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNRSDMDLID----SYG-------TP--------------STSYTSRELEAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGD 686
            VA+DRDKNS  A +WAV++L      ++ VHVK +          N ++  T+    D        E     +F   R +C  K I  K+ ++++ DV + L+E+A + +I  +VVG+S+K       +F    DI   + K APD+C+VY I+K K+ + ++A R     + P++I   Q          G++   P    T    +E +SF+S    S    S   RP         RS G      S +S +    PS   RN  S+ +       P   SN SD+D       ++G       +P              S S    ++EAEM+RL+LELKQTM+MYS+ACK+A++AK++  +++RW++ EE+K  E +L++EAALA+AE+EKA++KAA+EAAE A+  A++E+ +R +AE KA+KE+E R + + ALA+ D RYRKY++EEIE AT+ F    KIGEG YGPV+K +LDHT VA+K L P+A+QGR QFQ+EVEVL  IRHPNMVLLLGACPE GCLVYE+M NGSLEDRLFR+  S  LSWQ RF+IAAEI T LLFLHQTKPEP+VHRDLKP+NILLDRN+VSK++DVGLARLVPPSV + VTQY+MTS AGTFCYIDPEYQQTG+L  +SD+YSLGIM LQ+IT +PPMGLTH V++A+EKG  + +LDPAV+DWPVE+   FAK+AL CAE+ +KDRP L+KV+LPE+NRLR L +
Sbjct:   20 VAIDRDKNSQGALKWAVDNLLQKGQTVVLVHVKPRASSLSTNPSINSNSSKTSQINGDSSLVCGEPEGSYKQLFLPFRCLCSRKDIQCKDVLLEESDVARALVEYANQVMIEVLVVGSSSKG---GFLRFNKPIDIPGAITKTAPDFCTVYAITKGKLSTKKTASR-AAPSVSPLRIQLQQ---------NGLKPHPPLPSATTNTRAERQSFESQHRRSLDDQSDSFRPPYNKRGLTGRSYGELSIPDSEISFNSSGRPSIE-RNSPSLYDNSDPNRTPPRLSNFSDVDYCSFESMTFGRRSMDLSSPTAFSTGSFENERFSSASQGGDDVEAEMRRLKLELKQTMEMYSTACKEALTAKHKATELQRWKLAEERKFEEAKLAEEAALAIAEKEKAKSKAAMEAAEAAQRIADIESRKRVDAETKALKESEARTKAVNALAK-DVRYRKYSIEEIEDATEFFDDKYKIGEGSYGPVYKCYLDHTPVAVKALRPDAAQGRSQFQKEVEVLCSIRHPNMVLLLGACPECGCLVYEFMANGSLEDRLFRQGDSPALSWQTRFRIAAEIGTVLLFLHQTKPEPLVHRDLKPANILLDRNFVSKLADVGLARLVPPSVANTVTQYHMTSTAGTFCYIDPEYQQTGMLGVKSDIYSLGIMFLQLITGKPPMGLTHYVERALEKGNLKDLLDPAVSDWPVEDTTEFAKLALKCAEIRRKDRPDLSKVILPELNRLRVLAE 738          

Query:    1 MSLPPPTGPPQQ----NTMVAVDRDKNSAYAFRWAVNHLDN--PVIIAVHVKHKNLSNQGTNVFPPD-----EDDVSHIFSNLRAMCQSKAITMKEAVIDDYDVVKGLLEFAKRNVIHSIVVGASTKNHMPSIKKFKANNDIATNMIKLAPDYCSVYIISKLKIVSARSAVRP--MVNQIIPMKI------LPVQA--------------SSPYGEFEGGMRSILPRTG-GTYEGSSESRSFDSISTVKGS-----TRERPRSTGSNMSLDCIDVPSSRGRNWASMDERDMAALGPIVESNR-----SDMDLIDSYGTPS------TSYTSREL---EAEMKRLRLELKQTMDMYSSACKQAISAKNQVDQIRRWRVEEEKKVVEVRLSQEAALAMAEREKARAKAALEAAEEAKWKAELEAHRRREAEMKAMKEAEERDRVLTALAQHDNRYRKYTMEEIEVATDRFSPSKKIGEGGYGPVFKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEYMDNGSLEDRLFRKNKSKPLSWQKRFQIAAEISTALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPPSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTRSDVYSLGIMLLQIITARPPMGLTHQVKKAIEKGCFEQILDPAVTDWPVEEALSFAKIALGCAELCKKDRPSLAKVVLPEINRLRDLGD 686
            M LP   G  ++    +  VA+D+DK S +A +W +++L +    I  +HV  ++ S+       P      E     +F +    C  K I  ++ +++D D V+ + E+   + I ++VVG++++N    +++FK   D+ T + K APD+C+VY+ISK KI S R+A RP    N +   +I       P +A              S P    E     ++ R   G +  S    SF S S+ + S     +  RP    S+ SLD  +  S+R    ++  E+ +        SNR     SD D ++   T S      +SY+S+ L   EAEMKRLRLELKQTMDMYS+ACK+A+SA+ Q  ++++ R EEE+++ E + S+EAA+++ E+E+A+AKAALEAAE AK  AE+E+ RR  AEMK MKE++   R          RYRKYT++EIE AT  F+ S+K+GEGGYGPVF+G LDHT+VA+K+L P+A+QGR QFQ+EVEVLSCIRHPNMVLLLGACPE G LVYEYM  GSLEDRLF +  + P++WQ RF+IAAEI+T LLFLHQTKPEPIVHRDLKP N+LLD NYVSKISDVGLARLV P+V +NVTQY +TSAAGTFCYIDPEYQQTG+L  +SDVYSLGIMLLQI+TA+ PMGL + V++AIE+G  + +LDPAV DWP+EEALS AK++L CAEL +KDRP L K +LPE+NRLR++G+
Sbjct:    1 MWLPKANGAKKETGSGSVAVAIDKDKGSQHALKWTIDNLASRGQTISLIHVLCRSHSSSDLEEGTPQQKQQMEKIAKDLFVSFHCYCSRKEINCRDILLEDADKVRAITEYVSSSAIENLVVGSASRNGF--MRRFK--TDLPTTVSKSAPDFCNVYVISKGKIASVRNASRPAPYQNSMQQCEIDNHHPHTPDKAPKYHDHPNSAGSTPSRPRKSVEADRSPLVKRKPYGDFYDSDSDLSFISPSSHRDSDISFISSGRPSVERSSFSLDFPE--SARTSRMSTSSEQSIG-------SNRLGIKFSDPDFLNESSTFSEESGRTSSYSSQSLDDVEAEMKRLRLELKQTMDMYSTACKEALSARQQATELQKLRTEEERRLEEAKSSEEAAMSIVEKERAKAKAALEAAEAAKRLAEVESKRRLTAEMKTMKESDSFSRGFV-------RYRKYTVDEIEEATSNFAESQKVGEGGYGPVFRGFLDHTSVAVKVLRPDAAQGRSQFQKEVEVLSCIRHPNMVLLLGACPEFGILVYEYMAKGSLEDRLFMRGNTPPITWQLRFRIAAEIATGLLFLHQTKPEPIVHRDLKPGNVLLDYNYVSKISDVGLARLV-PAVAENVTQYRVTSAAGTFCYIDPEYQQTGMLGVKSDVYSLGIMLLQILTAKQPMGLAYYVEQAIEEGTLKDMLDPAVPDWPIEEALSLAKLSLQCAELRRKDRPDLGKEILPELNRLREIGE 718