Vfaba.Hedin2.R1.5g187440.1

Query:    4 YHIVIIFLLQMITSTKPLSFHYQTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLE-NDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVYP-TAISTIFDPVSFPSEAY 660
            + I II L QMIT  KP+SF+Y+ FKYDDVKLEGDASLL SYIQLTST+RYQSNA+SVGRVT FEPL LWDKTSRK+TDFTT+FSF+IYSNETGFGDGLAFF+ADPELP + + KEGGGLGLVDKYQILNS+++SF+AVEFDTHQN WDP GIHVGIN NSM+SQKTKPWLIDI+NKK YY CKIQYNSS + LKVSFTGNIV+ KPVK+Y+SYNVDLRDYLPE+VIFGFSAATGLMFEMNT+KSWSFNSSLE  D+K+SS I +   PS  PNS K  S K T+W  LGVGVGIA IFL+LG  C L+WKRAK +KEDS FDMKMDDEFQKGTGPK+FCYNKL +ATNNFEETQKIGQGGFGGVYKGYLK+IDSNVAIKRIS+ESKQGIKEYATEVKIIS+LRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKS+LTW +RYNIAMDLASALLYLHEEWEQCV+HRDIK+SNIMLD +FNAKLGDFGLARLVDHEKVSQ  TT+IAGTMGYIAPEYFTTGKATKESDIYSFGIVSLEL SGRKPID  AKE QV+IFD V  LYRLG+LLEV D KL G FDEEQMERLVVIGLWCANPNYS RP VRQVIQVLKFEA LPIL + MFES YP T +STIFDPVSFPSEAY
Sbjct:    9 HAIGIILLFQMITLVKPISFNYEGFKYDDVKLEGDASLLDSYIQLTSTSRYQSNAFSVGRVTFFEPLQLWDKTSRKITDFTTKFSFVIYSNETGFGDGLAFFIADPELPFVGYTKEGGGLGLVDKYQILNSTEHSFLAVEFDTHQNGWDPYGIHVGINFNSMVSQKTKPWLIDIRNKKTYYYCKIQYNSSAYTLKVSFTGNIVNDKPVKTYLSYNVDLRDYLPERVIFGFSAATGLMFEMNTIKSWSFNSSLEIQDDKLSSPISTTPSPSPIPNSLKISSNKRTVWAGLGVGVGIASIFLILGCFCFLMWKRAKEKKEDSNFDMKMDDEFQKGTGPKKFCYNKLVSATNNFEETQKIGQGGFGGVYKGYLKDIDSNVAIKRISRESKQGIKEYATEVKIISQLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSILTWQVRYNIAMDLASALLYLHEEWEQCVIHRDIKSSNIMLDDSFNAKLGDFGLARLVDHEKVSQ-STTIIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELASGRKPIDRKAKEGQVAIFDRVWDLYRLGRLLEVVDTKLGGAFDEEQMERLVVIGLWCANPNYSCRPSVRQVIQVLKFEASLPILSEEMFESTYPTTTMSTIFDPVSFPSEAY 666          

Query:    4 YHIVIIFLLQMITSTKPLSFHYQTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLE-NDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVYP-TAISTIFDPVSFPSEAY 660
            + I II L QMIT  KP+SF+Y+ FKYDDVKLEGDASLL SYIQLTST+RYQSNA+SVGRVT FEPL LWDKTSRK+TDFTT+FSF+IYSNETGFGDGLAFF+ADPELP + + KEGGGLGLVDKYQILNS+++SF+AVEFDTHQN WDP GIHVGIN NSM+SQKTKPWLIDI+NKK YY CKIQYNSS + LKVSFTGNIV+ KPVK+Y+SYNVDLRDYLPE+VIFGFSAATGLMFEMNT+KSWSFNSSLE  D+K+SS I +   PS  PNS K  S K T+W  LGVGVGIA IFL+LG  C L+WKRAK +KEDS FDMKMDDEFQKGTGPK+FCYNKL +ATNNFEETQKIGQGGFGGVYKGYLK+IDSNVAIKRIS+ESKQGIKEYATEVKIIS+LRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKS+LTW +RYNIAMDLASALLYLHEEWEQCV+HRDIK+SNIMLD +FNAKLGDFGLARLVDHEKVSQ  TT+IAGTMGYIAPEYFTTGKATKESDIYSFGIVSLEL SGRKPID  AKE QV+IFD V  LYRLG+LLEV D KL G FDEEQMERLVVIGLWCANPNYS RP VRQVIQVLKFEA LPIL + MFES YP T +STIFDPVSFPSEAY
Sbjct:   20 HAIGIILLFQMITLVKPISFNYEGFKYDDVKLEGDASLLDSYIQLTSTSRYQSNAFSVGRVTFFEPLQLWDKTSRKITDFTTKFSFVIYSNETGFGDGLAFFIADPELPFVGYTKEGGGLGLVDKYQILNSTEHSFLAVEFDTHQNGWDPYGIHVGINFNSMVSQKTKPWLIDIRNKKTYYYCKIQYNSSAYTLKVSFTGNIVNDKPVKTYLSYNVDLRDYLPERVIFGFSAATGLMFEMNTIKSWSFNSSLEIQDDKLSSPISTTPSPSPIPNSLKISSNKRTVWAGLGVGVGIASIFLILGCFCFLMWKRAKEKKEDSNFDMKMDDEFQKGTGPKKFCYNKLVSATNNFEETQKIGQGGFGGVYKGYLKDIDSNVAIKRISRESKQGIKEYATEVKIISQLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSILTWQVRYNIAMDLASALLYLHEEWEQCVIHRDIKSSNIMLDDSFNAKLGDFGLARLVDHEKVSQ-STTIIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELASGRKPIDRKAKEGQVAIFDRVWDLYRLGRLLEVVDTKLGGAFDEEQMERLVVIGLWCANPNYSCRPSVRQVIQVLKFEASLPILSEEMFESTYPTTTMSTIFDPVSFPSEAY 677          

Query:    4 YHIVIIFLLQMITSTKPLSFHY-QTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVK-SYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIP--SNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILP-QNMFESVY--PTAISTIF 650
            + I I FLLQ+ITS KPLSFHY Q+FKYDDVKLEGDASLLY YIQLT+T+RYQSNAYSVGRVT FEP+ LWD+TSRKLTDFTTQFSF I+SNETGFGDGLAFF ADP+LPL +H+++GGGLGLV+  QI+NS++YSFVAVEFDTHQN WDPSG HVGIN NSM SQ TKPW IDI+NKK YY CKI+YNSS H+LKVSFTGNI++GKP+K SY+SYNVDLRDYLP+KVIFGFSAATG MFEMNTLKSWSFNS+L++      +IP  +N  PS    SPK DS K TIW+ LGVGV +A  FL+LGW CIL+WKRAK +KEDS FD+KMDDEFQKGTGPKRFCYNKLA+ATNNFEE+QKIGQGGFG VYKGYLK+IDSNVAIKRIS+ESKQGIKEYATEVKIIS+LRHRNLVQLIGWCH KKD LLIYEFMQNGSLDSHLYRGKS+LTW MRYNIAMDLASALLYLHEEWEQCVLHRDIK+SNIMLD NFNAK+GDFGLARLVDHEK SQ  TTVIAGTMGY+APEYFTTGKATKESDIYSFGIVSLELVSGRKP+DL AKEDQ++I+DWV  LYRLG+ +EV D KL GVFDE +MERLVV+GLWCANPNYS RP VRQ+IQVLKFEA LPILP Q M +S Y  PT ++T+F
Sbjct:    9 HAIGITFLLQIITSVKPLSFHYNQSFKYDDVKLEGDASLLYPYIQLTATSRYQSNAYSVGRVTSFEPVQLWDRTSRKLTDFTTQFSFTIFSNETGFGDGLAFFFADPKLPLHNHIQQGGGLGLVNDDQIMNSTEYSFVAVEFDTHQNSWDPSGTHVGINFNSMKSQITKPWFIDIRNKKTYY-CKIEYNSSAHNLKVSFTGNIINGKPIKKSYLSYNVDLRDYLPDKVIFGFSAATGYMFEMNTLKSWSFNSTLQSHH---DNIPQIANPAPSPIKISPKIDSNKGTIWIGLGVGVVVASSFLILGWFCILMWKRAKMKKEDSTFDLKMDDEFQKGTGPKRFCYNKLASATNNFEESQKIGQGGFGVVYKGYLKDIDSNVAIKRISRESKQGIKEYATEVKIISQLRHRNLVQLIGWCHRKKDLLLIYEFMQNGSLDSHLYRGKSVLTWHMRYNIAMDLASALLYLHEEWEQCVLHRDIKSSNIMLDSNFNAKVGDFGLARLVDHEKGSQ--TTVIAGTMGYLAPEYFTTGKATKESDIYSFGIVSLELVSGRKPVDLNAKEDQMAIYDWVWELYRLGRFVEVVDTKLGGVFDEMKMERLVVVGLWCANPNYSLRPSVRQLIQVLKFEAALPILPLQKMNDSSYYAPTKMNTVF 656          

Query:    1 MNTYH-----IVIIFLLQMIT-STKPLSFHYQT-FKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDG---KPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPN---SPKPDSKK--STIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPIL 633
            M TYH     I IIFLLQMIT S KPLSF+YQ  FKYD+VKLEGDASL+YSYIQLTST+RYQSNAYSVGRVT FEPL LWDK SRKLTDFTTQFSF+IYSNET FGDGL FF ADPELPL  H+K+GGGLGLVD + I++S +YSF+AVEFDT+ N WDPSG HVGIN NSM+S  TKPW IDI +K  +Y CKI+YNSS H+L VSFTGNI  G   +P KSY+SYNVDLRD LPEKVI GFSAATG MFEMN LKSWSFNSSL   ++ SS IP+N  PS  PN   SPK  S++  S+IW+ LGVGV IA  FL+LG +C LIWKR KG+KEDS+FDMKMDDEFQ GTGPK+FCY+KLA+ATNNF E QKIGQGGFGGVYKGYLK+IDSNVAIKRIS+ESKQGIKEYATEVKIIS+LRHRNLVQLIGWCH KKDFLLIYEFMQNGSLDSHLY GKS+LTW MRYNIA+DLA ALLYLHEEWEQCVLHRDIK+SNIMLD NFNAKLGDFGLARLVD+EK SQ +TTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLEL SGRKP+DL AKEDQ++IFDWV  LYRLG+LLEV D KLEG FD+EQMERLVVIGLWCANPNYSFRP VRQVIQVLKFEAPLPIL
Sbjct:    1 MATYHVGLHEIGIIFLLQMITISVKPLSFNYQQGFKYDNVKLEGDASLMYSYIQLTSTSRYQSNAYSVGRVTSFEPLQLWDKASRKLTDFTTQFSFVIYSNETDFGDGLTFFFADPELPLYYHIKQGGGLGLVDDFHIVHS-RYSFLAVEFDTYHNSWDPSGTHVGINFNSMISNITKPWFIDIMSKTAHYDCKIEYNSSTHNLNVSFTGNITYGDIFEPSKSYISYNVDLRDCLPEKVIVGFSAATGYMFEMNKLKSWSFNSSLNIHDENSSPIPTNPSPSPIPNVKISPKIVSRRGTSSIWVELGVGVAIAASFLILGGVCNLIWKRTKGKKEDSLFDMKMDDEFQNGTGPKKFCYHKLASATNNFAEKQKIGQGGFGGVYKGYLKDIDSNVAIKRISRESKQGIKEYATEVKIISQLRHRNLVQLIGWCHKKKDFLLIYEFMQNGSLDSHLYHGKSVLTWQMRYNIAIDLALALLYLHEEWEQCVLHRDIKSSNIMLDDNFNAKLGDFGLARLVDYEKGSQSQTTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELASGRKPVDLNAKEDQMAIFDWVWELYRLGRLLEVVDTKLEGGFDDEQMERLVVIGLWCANPNYSFRPSVRQVIQVLKFEAPLPIL 647          

Query:    4 YHIVIIFLLQM-ITSTKPLSFHYQT-FKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPN---SPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEA 628
            + I IIFL QM ITS KPLSF+YQ  FKYD+VKLEGDASLLYS IQLTST+ Y+   YSVGRVTCFEPL LW+KTSRKLTDFTTQFSF+I+SN+T FGDGLAFF ADP LPL  H+++GGGLGLV+ YQILNS+ YSFVAVEFDTHQN WDP G HVGIN NS+ S  TKPW +DI+NKK Y+ CKI+YNSS HDLKVSFT NI +G+P  S++SYNVDLRDYLPE+VIFGFSAATG MFEMN L SWSFNSSL     V S       PS  PN   S K DSK  +IW+ +GVGVGIA  FL+LGW CI +WKR+KG KEDSIFD+KMDDEFQKGTGPK+FCYNKL +ATNNF E +KIGQGGFGGVYKGYLK+ID+NVAIKRIS+ESKQGIKEYATEVKII +LRHRNLVQLIGWCH K+DFLLIYEFMQNGSLDSHLYRGKS+LTW MRYNIAMDLASALLYLHEEWEQCVLHRD+K+SNIMLD NFNAKLGDFGLARLVDHEK SQ +TT+IAGTMGYIAPEY TTGKATKESDIYSFGIVSLEL SGRKP+DL AKEDQ++IFDWV  LYRLG+LLEV D KL G FDEEQMERLVVIGLWCANPNYSFRP VRQVIQVLK EA
Sbjct:   27 HEIGIIFLFQMMITSVKPLSFNYQQGFKYDNVKLEGDASLLYSSIQLTSTSSYEDETYSVGRVTCFEPLQLWEKTSRKLTDFTTQFSFVIFSNKTYFGDGLAFFFADPRLPLYYHIRQGGGLGLVNDYQILNSNGYSFVAVEFDTHQNDWDPPGTHVGINFNSLRSNITKPWFMDIRNKKAYH-CKIEYNSSAHDLKVSFTENITNGEPSYSHLSYNVDLRDYLPERVIFGFSAATGYMFEMNKLLSWSFNSSLNQTSPVES-------PSPVPNIKISIKTDSKAGSIWVGVGVGVGIASSFLILGWFCISMWKRSKGNKEDSIFDLKMDDEFQKGTGPKKFCYNKLVSATNNFAEAEKIGQGGFGGVYKGYLKDIDTNVAIKRISRESKQGIKEYATEVKIIGQLRHRNLVQLIGWCHKKRDFLLIYEFMQNGSLDSHLYRGKSVLTWQMRYNIAMDLASALLYLHEEWEQCVLHRDVKSSNIMLDNNFNAKLGDFGLARLVDHEKGSQSDTTIIAGTMGYIAPEYITTGKATKESDIYSFGIVSLELASGRKPVDLNAKEDQMAIFDWVWELYRLGRLLEVVDTKLGGAFDEEQMERLVVIGLWCANPNYSFRPSVRQVIQVLKLEA 648          

Query:    4 YHIVIIFLLQM-ITSTKPLSFHYQT-FKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPN---SPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEA 628
            + I IIFL QM ITS KPLSF+YQ  FKYD+VKLEGDASLLYS IQLTST+ Y+   YSVGRVTCFEPL LW+KTSRKLTDFTTQFSF+I+SN+T FGDGLAFF ADP LPL  H+++GGGLGLV+ YQILNS+ YSFVAVEFDTHQN WDP G HVGIN NS+ S  TKPW +DI+NKK Y+ CKI+YNSS HDLKVSFT NI +G+P  S++SYNVDLRDYLPE+VIFGFSAATG MFEMN L SWSFNSSL     V S       PS  PN   S K DSK  +IW+ +GVGVGIA  FL+LGW CI +WKR+KG KEDSIFD+KMDDEFQKGTGPK+FCYNKL +ATNNF E +KIGQGGFGGVYKGYLK+ID+NVAIKRIS+ESKQGIKEYATEVKII +LRHRNLVQLIGWCH K+DFLLIYEFMQNGSLDSHLYRGKS+LTW MRYNIAMDLASALLYLHEEWEQCVLHRD+K+SNIMLD NFNAKLGDFGLARLVDHEK SQ +TT+IAGTMGYIAPEY TTGKATKESDIYSFGIVSLEL SGRKP+DL AKEDQ++IFDWV  LYRLG+LLEV D KL G FDEEQMERLVVIGLWCANPNYSFRP VRQVIQVLK EA
Sbjct:    9 HEIGIIFLFQMMITSVKPLSFNYQQGFKYDNVKLEGDASLLYSSIQLTSTSSYEDETYSVGRVTCFEPLQLWEKTSRKLTDFTTQFSFVIFSNKTYFGDGLAFFFADPRLPLYYHIRQGGGLGLVNDYQILNSNGYSFVAVEFDTHQNDWDPPGTHVGINFNSLRSNITKPWFMDIRNKKAYH-CKIEYNSSAHDLKVSFTENITNGEPSYSHLSYNVDLRDYLPERVIFGFSAATGYMFEMNKLLSWSFNSSLNQTSPVES-------PSPVPNIKISIKTDSKAGSIWVGVGVGVGIASSFLILGWFCISMWKRSKGNKEDSIFDLKMDDEFQKGTGPKKFCYNKLVSATNNFAEAEKIGQGGFGGVYKGYLKDIDTNVAIKRISRESKQGIKEYATEVKIIGQLRHRNLVQLIGWCHKKRDFLLIYEFMQNGSLDSHLYRGKSVLTWQMRYNIAMDLASALLYLHEEWEQCVLHRDVKSSNIMLDNNFNAKLGDFGLARLVDHEKGSQSDTTIIAGTMGYIAPEYITTGKATKESDIYSFGIVSLELASGRKPVDLNAKEDQMAIFDWVWELYRLGRLLEVVDTKLGGAFDEEQMERLVVIGLWCANPNYSFRPSVRQVIQVLKLEA 630          

Query:    8 IIFLLQMITSTKPLSFHYQTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETG-FGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIP---------SNLEPSRTPN-SPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVY--PTAISTIFDPVSFPS 657
            IIFL+ MI+   PLSFHYQ F+YDD ++EGDA+L +S IQLT+TTRYQSNAYSVGRVT FE LHLWD +S  LTDFTTQFSF+I+SN++  FGDGLAFF ADP+LPL   ++EGGGLGLVD  Q+L S+ + FVAVEFDTHQN WDP G HVGIN NSM S  T PW IDI+  K  Y C I+YN+S H+L VSFTGN ++GKP+KS++S NVDLRDYLPE VIFGFSAATG MFEMNTL+SWSF+SSL+++E VS  IP          +  P  T N SP  +  K  + + + +G+GIA  FL+LG +CIL+WKRAKG+KEDS+FD+ MDDEFQKG GPKRFCY KLA+ATNNF ETQKIGQGGFGGVYKGYLK+++SNVAIKRIS+ES+QGIKEY +EVKIIS+LRHRNLVQLIGWCHMKKD LLIYEFMQNGSLDSHLYRGKS+LTW MRYNIAMDLA A+LYLHEEW+QCVLHRDIK+SN+MLD +F+AKLGDFGLARLVDHEK SQ  TT +AGTMGYIAPEYFT GKA KESDIYSFG+V LEL SGRKPIDL A E Q++IF+WV  LYRLGKLLEV D+KL G FDEEQME LVV+GLWCANP+Y+ RP +RQVIQVLK EAPLPILPQ   E  Y  P  +STIF  VS PS
Sbjct:    3 IIFLVPMISLVNPLSFHYQGFEYDDARIEGDATLSHSQIQLTATTRYQSNAYSVGRVTSFELLHLWDMSSGNLTDFTTQFSFVIFSNDSSSFGDGLAFFFADPKLPLSKQIQEGGGLGLVDGNQLLKSTSHPFVAVEFDTHQNSWDPPGTHVGINFNSMRSNITAPWSIDIRQMK-VYCCVIEYNASTHNLNVSFTGNKINGKPIKSHISCNVDLRDYLPEWVIFGFSAATGSMFEMNTLQSWSFHSSLQSNENVSRQIPPMAASPIPNPSPSPIATANISPTQEDNKGLL-MGIEIGIGIAASFLILGLVCILMWKRAKGKKEDSLFDLSMDDEFQKGIGPKRFCYKKLASATNNFAETQKIGQGGFGGVYKGYLKDLNSNVAIKRISRESRQGIKEYVSEVKIISQLRHRNLVQLIGWCHMKKDLLLIYEFMQNGSLDSHLYRGKSILTWQMRYNIAMDLALAVLYLHEEWKQCVLHRDIKSSNVMLDSSFSAKLGDFGLARLVDHEKGSQ--TTTLAGTMGYIAPEYFTIGKARKESDIYSFGVVLLELASGRKPIDLKANEGQITIFEWVWELYRLGKLLEVVDQKLGGAFDEEQMEHLVVVGLWCANPDYTTRPSIRQVIQVLKLEAPLPILPQKTPEPYYHSPPTMSTIFASVSSPS 661          

Query:    8 IIFLLQMITSTKPLSFHYQTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIP-------SNLEPSRTPN---SPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVY--PTAISTIFDPVS 654
            I+F L MIT   PLSFHYQ F+Y+D ++EGDA+L +S IQLT+TTRYQSNAYSVGRVT F+ L LWD +S KLTDFTT+FSF+IYSNET FGDG AFF ADP+LPL + +++GGGLGLVD  ++L  ++Y FVAVEFDTHQN WDP G HVGIN NSM S  T PW IDI+  K YY C I+YN+S H+L VSFTGN ++GKP+KSY+S NV+LRDYLPE+VIFGFSAATG MFEMNTL SWSF SSL +DEKVS+ IP        N  PS  P    SPK +  K  +   +  G+GIA  FL+LG +CI IWKRAK +KEDS+FD+ MDDEFQKG GPKRFCY +LA+ATNNF E QKIGQGGFGGVYKGYLK+++SNVAIKRIS+ES+QGIKEYA EVKIIS+LRHRNLVQLIGWCHMKKD LLIYEFMQNGSLDSHLYRGKS+LTW MRYNIAMDLA A+LYLHEEWEQCVLHRDIK+SN+MLD +FNAKLGDFGLARLVDHEK SQ  TT++AGT+GYIAPEY TTGKA KESDIYSFG+V LEL SGRKPIDL AKE Q++IF+WV  LYRLGKLLEV D KL G FDEEQME LV++GLWCANP+Y+ RP VRQVIQVL FEAPLP+LPQ M E  +  PT +STIF  VS
Sbjct:   21 IVFFL-MITFVNPLSFHYQGFEYNDARIEGDATLSHSEIQLTATTRYQSNAYSVGRVTSFKLLQLWDMSSGKLTDFTTEFSFVIYSNETSFGDGFAFFFADPKLPLSNQIQQGGGLGLVDGNRLLKPTKYPFVAVEFDTHQNSWDPPGTHVGINFNSMRSNITVPWSIDIRQMKVYY-CAIEYNASTHNLNVSFTGNQINGKPIKSYISCNVNLRDYLPERVIFGFSAATGFMFEMNTLLSWSFRSSLPSDEKVSNQIPPMAAPPIQNPSPSPFPTANISPKQEGNKGLL-KGIEAGIGIAASFLILGLVCIFIWKRAKLKKEDSVFDLSMDDEFQKGIGPKRFCYKELASATNNFAEAQKIGQGGFGGVYKGYLKKLNSNVAIKRISRESRQGIKEYAAEVKIISQLRHRNLVQLIGWCHMKKDLLLIYEFMQNGSLDSHLYRGKSILTWQMRYNIAMDLALAVLYLHEEWEQCVLHRDIKSSNVMLDLSFNAKLGDFGLARLVDHEKGSQ--TTILAGTVGYIAPEYCTTGKARKESDIYSFGVVLLELASGRKPIDLNAKEGQITIFEWVWELYRLGKLLEVVDSKLGGAFDEEQMEHLVIVGLWCANPDYTSRPSVRQVIQVLTFEAPLPVLPQKMPEPYHHSPT-MSTIFASVS 673          

Query:    8 IIFLLQMITSTKPLSFHYQTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIP-------SNLEPSRTPN---SPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVY--PTAISTIFDPVS 654
            I+F L MIT   PLSFHYQ F+Y+D ++EGDA+L +S IQLT+TTRYQSNAYSVGRVT F+ L LWD +S KLTDFTT+FSF+IYSNET FGDG AFF ADP+LPL + +++GGGLGLVD  ++L  ++Y FVAVEFDTHQN WDP G HVGIN NSM S  T PW IDI+  K YY C I+YN+S H+L VSFTGN ++GKP+KSY+S NV+LRDYLPE+VIFGFSAATG MFEMNTL SWSF SSL +DEKVS+ IP        N  PS  P    SPK +  K  +   +  G+GIA  FL+LG +CI IWKRAK +KEDS+FD+ MDDEFQKG GPKRFCY +LA+ATNNF E QKIGQGGFGGVYKGYLK+++SNVAIKRIS+ES+QGIKEYA EVKIIS+LRHRNLVQLIGWCHMKKD LLIYEFMQNGSLDSHLYRGKS+LTW MRYNIAMDLA A+LYLHEEWEQCVLHRDIK+SN+MLD +FNAKLGDFGLARLVDHEK SQ  TT++AGT+GYIAPEY TTGKA KESDIYSFG+V LEL SGRKPIDL AKE Q++IF+WV  LYRLGKLLEV D KL G FDEEQME LV++GLWCANP+Y+ RP VRQVIQVL FEAPLP+LPQ M E  +  PT +STIF  VS
Sbjct:   21 IVFFL-MITFVNPLSFHYQGFEYNDARIEGDATLSHSEIQLTATTRYQSNAYSVGRVTSFKLLQLWDMSSGKLTDFTTEFSFVIYSNETSFGDGFAFFFADPKLPLSNQIQQGGGLGLVDGNRLLKPTKYPFVAVEFDTHQNSWDPPGTHVGINFNSMRSNITVPWSIDIRQMKVYY-CAIEYNASTHNLNVSFTGNQINGKPIKSYISCNVNLRDYLPERVIFGFSAATGFMFEMNTLLSWSFRSSLPSDEKVSNQIPPMAAPPIQNPSPSPFPTANISPKQEGNKGLL-KGIEAGIGIAASFLILGLVCIFIWKRAKLKKEDSVFDLSMDDEFQKGIGPKRFCYKELASATNNFAEAQKIGQGGFGGVYKGYLKKLNSNVAIKRISRESRQGIKEYAAEVKIISQLRHRNLVQLIGWCHMKKDLLLIYEFMQNGSLDSHLYRGKSILTWQMRYNIAMDLALAVLYLHEEWEQCVLHRDIKSSNVMLDLSFNAKLGDFGLARLVDHEKGSQ--TTILAGTVGYIAPEYCTTGKARKESDIYSFGVVLLELASGRKPIDLNAKEGQITIFEWVWELYRLGKLLEVVDSKLGGAFDEEQMEHLVIVGLWCANPDYTSRPSVRQVIQVLTFEAPLPVLPQKMPEPYHHSPT-MSTIFASVS 673          

Query:   14 MITSTKPLSFHYQTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLE-NDEKVSSSIPSNLEPSRTPNSPKPDSKK-STIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVY-PTAISTIFDPVS 654
            + TS KPLSF YQ FKYDDVK EGDASLLYSYIQLTST+RYQ+N YSVGRVTCFEPL LWDKTSRKLTDFTT+FSF+IYSN+T FGDGLAFF ADPELPL +HM+EGGGLGLVDKYQI+NS++YSF+AVEFDTHQN WDPSG+HVGIN NSMMS KTKPW IDI NK  YY CKIQYNSS H+LKVS+TG+I++                           AATG++FEMNTL SWSFNSSL+ +D KVSS I +N  PS   NSPK DS K +TIW+ LGVGV                                                    +ATNNFEETQKIGQGGFGGVYKGYLK+ID+NVAIKRIS+ESKQGIKEYATEVKIIS+LRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTW MRYNIAMDLASALLYLHEEWEQCV+HRDIK+SNIMLDYNFNAKLGDFG+ARLVDHEK SQ  TT+IAGTMGYIAPEY+TTGKATKESDIYSFGIVSLEL SGRKPIDL AKEDQV+IFDWV  LYRLG+ LEV D KLEG+FDEEQMERLVVIGLWCANPNYSFRP  RQVIQVLKFEAPLPIL   M ES+Y P  ++TIF PVS
Sbjct:    2 ITTSVKPLSFDYQGFKYDDVKPEGDASLLYSYIQLTSTSRYQTNTYSVGRVTCFEPLQLWDKTSRKLTDFTTKFSFVIYSNKTNFGDGLAFFFADPELPLPEHMQEGGGLGLVDKYQIMNSTKYSFLAVEFDTHQNSWDPSGMHVGINFNSMMSIKTKPWSIDISNKTAYYDCKIQYNSSAHNLKVSYTGSIIN---------------------------AATGVVFEMNTLMSWSFNSSLQIHDVKVSSPISTNPSPSPIHNSPKIDSNKYTTIWVGLGVGV---------------------------------------------------VSATNNFEETQKIGQGGFGGVYKGYLKDIDTNVAIKRISRESKQGIKEYATEVKIISQLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWPMRYNIAMDLASALLYLHEEWEQCVIHRDIKSSNIMLDYNFNAKLGDFGMARLVDHEKESQ-STTIIAGTMGYIAPEYYTTGKATKESDIYSFGIVSLELASGRKPIDLNAKEDQVTIFDWVRELYRLGRFLEVVDTKLEGIFDEEQMERLVVIGLWCANPNYSFRPSARQVIQVLKFEAPLPILQHMMLESIYSPKTMNTIFGPVS 566          

Query:    9 IFLLQMITSTKPLSFHYQTFKYD--DVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGD---GLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNP-WDPSGI--HVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAK--EDQVSIFDWVLGLYRLGKLLEVADRKLE-GVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVY 642
            + +L  + S +   F+   F  D  ++  +GDA      ++LT+   Y   A   G  T  + + LW+  + K +DF+T+FSF I +   G+G+   G AFFLA   + L  +   GG LGL +      SS +  V VEFDT  NP WDP  +  HVGIN NS++S     W     N+       I Y+S+  +L VS+T ++       S +SY +DL   LP +V  GFSA +G + E N L SW F+SSLE                   +  K  + K  + + + V   +   F +   +  L  K+ K + E++     ++++ ++G GP++F Y  LA+A NNF + +K+G+GGFG VY+GYL  +D  VAIK+ +  SKQG +E+ TEVKIIS LRHRNLVQLIGWCH K +FL+IYEFM NGSLD+HL+  K  L W +R  I + LASALLYLHEEWEQCV+HRDIK SN+MLD NFNAKLGDFGLARL+DHE   Q  TT +AGT GY+APEY +TG+A+KESD+YSFG+V+LE+V+GRK +D      E   ++ + +  LY  G+++   D KL  G FDE+Q E L+++GLWCA+P+ + RP ++Q IQVL  EAP+P LP  M  + Y
Sbjct:   11 VLVLPFVCSVQ---FNISRFGSDVSEIAYQGDARA-NGAVELTNID-YTCRA---GWATYGKQVPLWNPGTSKPSDFSTRFSFRIDTRNVGYGNYGHGFAFFLAPARIQLPPN-SAGGFLGLFNGTNN-QSSAFPLVYVEFDTFTNPEWDPLDVKSHVGINNNSLVSSNYTSWNATSHNQD-IGRVLIFYDSARRNLSVSWTYDLTSDPLENSSLSYIIDLSKVLPSEVTIGFSATSGGVTEGNRLLSWEFSSSLE-----------------LIDIKKSQNDKKGMIIGISVSGFVLLTFFITSLIVFLKRKQQKKKAEETENLTSINEDLERGAGPRKFTYKDLASAANNFADDRKLGEGGFGAVYRGYLNSLDMMVAIKKFAGGSKQGKREFVTEVKIISSLRHRNLVQLIGWCHEKDEFLMIYEFMPNGSLDAHLFGKKPHLAWHVRCKITLGLASALLYLHEEWEQCVVHRDIKASNVMLDSNFNAKLGDFGLARLMDHELGPQ--TTGLAGTFGYMAPEYISTGRASKESDVYSFGVVTLEIVTGRKSVDRRQGRVEPVTNLVEKMWDLYGKGEVITAIDEKLRIGGFDEKQAECLMIVGLWCAHPDVNTRPSIKQAIQVLNLEAPVPHLPTKMPVATY 625          

Query:   28 FKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYS-NETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNP-WDPS--GIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVK--SYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIA---WIFLVLGWLC-ILIWKR-AKGEKEDSIFDM-KMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLY-RGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAK-------EDQVSIFDWVLGLYRLGKLL-EVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILP 634
            F + D   + D ++ ++  + TS          VG +T  + + +W   + K +DF+T FSF I + N +  G G+ FFLA P    L     GG L L  +    +SS +  V VEFDT  NP WDP+  G HVGIN NS++S     W     + +     KI Y+S   +L V++   +      K  S +SY +DL   LP  V+FGF AA G   E + L SW  +SSL++D                    K DS       R+G+ +GI+   ++FL    +  +++W R  + +KE  I +M  ++ + ++  GP++F Y  L +ATN F   +K+G+GGFG VY+G LKEI++ VA+K++S +S+QG  E+  EVKIISKLRHRNLVQLIGWC+ K +FLLIYE + NGSL+SHL+ +  +LL+W +RY I + LASALLYLHEEW+QCVLHRDIK SNIMLD  FN KLGDFGLARL++HE  S   TT +AGT GY+APEY   G A+KESDIYSFGIV LE+V+GRK ++   +       +D+ S+ + V  LY   +L+    D KL   FD+++ E L+V+GLWCA+P+ + RP ++Q IQV+ FE+PLP LP
Sbjct:   52 FYHGDATPDEDGTVNFNNAEQTS---------QVGWITYSKKVPIWSHKTGKASDFSTSFSFKIDARNLSADGHGICFFLA-PMGAQLPAYSVGGFLNLFTRKNNYSSS-FPLVHVEFDTFNNPGWDPNDVGSHVGINNNSLVSSNYTSWNAS-SHSQDICHAKISYDSVTKNLSVTWAYELTATSDPKESSSLSYIIDLAKVLPSDVMFGFIAAAGTNTEEHRLLSWELSSSLDSD--------------------KADS-------RIGLVIGISASGFVFLTFMVITTVVVWSRKQRKKKERDIENMISINKDLEREAGPRKFSYKDLVSATNRFSSHRKLGEGGFGAVYEGNLKEINTMVAVKKLSGDSRQGKNEFLNEVKIISKLRHRNLVQLIGWCNEKNEFLLIYELVPNGSLNSHLFGKRPNLLSWDIRYKIGLGLASALLYLHEEWDQCVLHRDIKASNIMLDSEFNVKLGDFGLARLMNHELGSH--TTGLAGTFGYMAPEYVMKGSASKESDIYSFGIVLLEIVTGRKSLERTQEDNSDTESDDEKSLVEKVWELYGKQELITSCVDDKLGEDFDKKEAECLLVLGLWCAHPDKNSRPSIKQGIQVMNFESPLPDLP 638          

Query:   14 MITSTKPLSFHYQTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYS---NETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPW--DPSGIHVGINLNSMMSQKTK-PWL---IDIKNKKGYYSCKIQYNSSVHDLKV--SFTGNIVDGK-PVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSS--------LENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYR----GKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQ-VSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFE---APLP 631
            +  S+  ++F +++F   ++   GD+ L    + LT          S G V    P+  +D  S     F+T FSF + +   + T  GDGLAFFL+     L      GG LGLV+  Q +   +  FVA+EFDT  +P   DP+G H+G++++S+ S  T  P L   ID+K+ K   S  I Y + +  L V  S+T  +   K P K  +S N+DL  +L  ++  GFS +T    E++ +++WSF +S          +   VS S   N +P   P+  +       I L +   V I     V G+  +  WK  K EKE       +  E    TG + F Y +L TAT  F  ++ IG+G FG VY+       +  A+KR    S +G  E+  E+ II+ LRH+NLVQL GWC+ K + LL+YEFM NGSLD  LY+    G   L W  R NIA+ LASAL YLH E EQ V+HRDIKTSNIMLD NFNA+LGDFGLARL +H+K     +T+ AGTMGY+APEY   G AT+++D +S+G+V LE+  GR+PID   +  + V++ DWV  L+  G++LE  D +L+G FDEE M++L+++GL CA+P+ + RP +R+V+Q+L  E   +P+P
Sbjct:   24 IFVSSDNMNFTFKSFTIRNLTFLGDSHLRNGVVGLTRELGVPDT--SSGTVIYNNPIRFYDPDSNTTASFSTHFSFTVQNLNPDPTSAGDGLAFFLSHDNDTL---GSPGGYLGLVNSSQPM---KNRFVAIEFDTKLDPHFNDPNGNHIGLDVDSLNSISTSDPLLSSQIDLKSGKSITSW-IDYKNDLRLLNVFLSYTDPVTTTKKPEKPLLSVNIDLSPFLNGEMYVGFSGSTEGSTEIHLIENWSFKTSGFLPVRSKSNHLHNVSDSSVVNDDPVVIPSKKRRHRHNLAIGLGISCPVLICLALFVFGYFTLKKWKSVKAEKE-------LKTELI--TGLREFSYKELYTATKGFHSSRVIGRGAFGNVYRAMFVSSGTISAVKRSRHNSTEGKTEFLAELSIIACLRHKNLVQLQGWCNEKGELLLVYEFMPNGSLDKILYQESQTGAVALDWSHRLNIAIGLASALSYLHHECEQQVVHRDIKTSNIMLDINFNARLGDFGLARLTEHDKSPV--STLTAGTMGYLAPEYLQYGTATEKTDAFSYGVVILEVACGRRPIDKEPESQKTVNLVDWVWRLHSEGRVLEAVDERLKGEFDEEMMKKLLLVGLKCAHPDSNERPSMRRVLQILNNEIEPSPVP 649          

Query:   14 MITSTKPLSFHYQTFK--YDDVKLEGDASLL-YSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSN-ETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNP--WDPSGIHVGINLNSMMSQK--TKPWLID---IKNKKGYYSCKIQ----YNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVG-VGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRG-KSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLY-AKEDQVSIFDWVLGLYRLGKLLEVADRKL-EGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPIL 633
            MI+S++ L+F Y  F     D+ L+G A++     ++LT+T+  ++     G   C E +   D  +  ++ F+T F F I+S   T  G G+AF +A P L L   +     +GL +     N + + F AVEFDT Q+    DP+  HVGI+LN + S    T  +  D    +N       +IQ    Y++  H + V+      D KP K  +SY  DL   L E +  GFS+ATG +   + L  WSF        +++   P  L  S+ P  P+ + ++ + + ++G+  + ++ IF ++ +L   I +R K  +E+        D+++   G  RF + +L  AT  F+E   +G GGFG VY+G L      VA+KR+S +SKQG+KE+  E+  I ++ HRNLV L+G+C  + + LL+Y++M NGSLD +LY   ++ L W  R  I   +AS L YLHEEWEQ V+HRD+K SN++LD +FN +LGDFGLARL DH   S  +TT + GT+GY+APE+  TG+AT  +D+Y+FG   LE+VSGR+PI+ + A +D   + +WV  L+  G ++E  D KL    +D E++E ++ +GL C++ +   RP +RQV+Q L+ +  LP L
Sbjct:   18 MISSSQNLNFTYNGFHPPLTDISLQGLATVTPNGLLKLTNTSVQKT-----GHAFCTERIRFKDSQNGNVSSFSTTFVFAIHSQIPTLSGHGIAFVVA-PTLGLPFALPSQY-IGLFNISNNGNDTNHIF-AVEFDTIQSSEFGDPNDNHVGIDLNGLRSANYSTAGYRDDHDKFQNLSLISRKRIQVWIDYDNRSHRIDVTVAPFDSD-KPRKPLVSYVRDLSSILLEDMYVGFSSATGSVLSEHFLVGWSF--------RLNGEAPM-LSLSKLPKLPRFEPRRISEFYKIGMPLISLSLIFSII-FLAFYIVRRKKKYEEEL-------DDWETEFGKNRFRFKELYHATKGFKEKDLLGSGGFGRVYRGILPTTKLEVAVKRVSHDSKQGMKEFVAEIVSIGRMSHRNLVPLLGYCRRRGELLLVYDYMPNGSLDKYLYNNPETTLDWKQRSTIIKGVASGLFYLHEEWEQVVIHRDVKASNVLLDADFNGRLGDFGLARLYDHG--SDPQTTHVVGTLGYLAPEHSRTGRATTTTDVYAFGAFLLEVVSGRRPIEFHSASDDTFLLVEWVFSLWLRGNIMEAKDPKLGSSGYDLEEVEMVLKLGLLCSHSDPRARPSMRQVLQYLRGDMALPEL 628          

Query:   83 FTTQFSFIIYSN-ETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPW--DPSGIHVGINLNSMMSQKTKP--WLIDIKNKKGYY-------SCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIA---WIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLY--RGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLP-ILPQNMF 638
            F+T F+  +     T  G GLAF  A    P L        LGL++  ++  SS   F AVEFDT ++    D +  HVGI++NSM S  + P  + +    KK  +          I Y+S+   L V  +      KP  S +SY+VDL   L +++  GFSA+TGL+   + +  W+FN S    E  S S+PS       P  P    K+      L +GV +     IF VL    + + ++ K   ED + + ++D       GP RF Y +L  ATN F + + +G GGFG VYKG L   D  VA+KRIS ES+QG++E+ +EV  I  LRHRNLVQL+GWC  + D LL+Y+FM NGSLD +L+    + +LTW  R+ I   +AS LLYLHE WEQ V+HRDIK +N++LD   N ++GDFGLA+L +H   S    T + GT GY+APE   +GK T  +D+Y+FG V LE+  GR+PI+  A  +++ + DWV   ++ G + +V DR+L G FDEE++  ++ +GL C+N +   RP +RQV+  L+ + P P ++P   F
Sbjct:   84 FSTSFAIAMVPEFVTLGGHGLAF--AITPTPDLRGSLPSQYLGLLNSSRVNFSSH--FFAVEFDTVRDLEFEDINDNHVGIDINSMESSISTPAGYFLANSTKKELFLDGGRVIQAWIDYDSNKKRLDVKLSP--FSEKPKLSLLSYDVDLSSVLGDEMYVGFSASTGLLASSHYILGWNFNMS---GEAFSLSLPS------LPRIPSSIKKRKKKRQSLILGVSLLCSLLIFAVLVAASLFVVRKVK--DEDRVEEWELD------FGPHRFSYRELKKATNGFGDKELLGSGGFGKVYKGKLPGSDEFVAVKRISHESRQGVREFMSEVSSIGHLRHRNLVQLLGWCRRRDDLLLVYDFMPNGSLDMYLFDENPEVILTWKQRFKIIKGVASGLLYLHEGWEQTVIHRDIKAANVLLDSEMNGRVGDFGLAKLYEHG--SDPGATRVVGTFGYLAPELTKSGKLTTSTDVYAFGAVLLEVACGRRPIETSALPEELVMVDWVWSRWQSGDIRDVVDRRLNGEFDEEEVVMVIKLGLLCSNNSPEVRPTMRQVVMYLEKQFPSPEVVPAPDF 632          

Query:    8 IIFLLQMITSTKPLSFHYQTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYS-NETGFGDGLAFFLADPELPLLDHMK-EGGGLGLVDKYQILNSSQYSFVAVEFDTHQNP--WDPSGIHVGINLNSMMSQKTKPW-LIDIKNKKG-YYSCKIQYN--SSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLG----------------------------------VGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGT--GPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPI--DLYAKEDQVSI----FDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQN 636
            I  LL          F + T    ++KL GDA L    + LT      ++    G+V    P+      +   T F++ FSF I + N +  G GLAF ++    P  + +   GG LGL       N S   FVAVEFDT  +    D +  HVG ++N ++S  +     ++I  K G   +  I+Y+  + V ++ VS++    + KP    +S+ +DL  Y+ + +  GFS +T    E+++++ WSF+SS  +     S  P    P     +PK +S KS   L                                      GV  A  F +  +   L W  +K  K      ++  D F       PK F Y +L   T NF E++ IG G FG VY+G L E    VA+KR S  S+    E+ +E+ II  LRHRNLV+L GWCH K + LL+Y+ M NGSLD  L+  +  L W  R  I + +ASAL YLH E E  V+HRD+K+SNIMLD +FNAKLGDFGLAR ++H+K    E TV AGTMGY+APEY  TG+A++++D++S+G V LE+VSGR+PI  DL  +   V +     +WV GLY+ GK+   AD +LEG FDE +M R++V+GL C++P+ +FRP +R V+Q+L  EA +P++P++
Sbjct:    9 ISILLCFFNGATTTQFDFSTLAISNLKLLGDARLSNGIVGLTRDLSVPNSG--AGKVLYSNPIRFRQPGTHFPTSFSSFFSFSITNVNPSSIGGGLAFVIS----PDANSIGIAGGSLGLTGP----NGSGSKFVAVEFDTLMDVDFKDINSNHVGFDVNGVVSSVSGDLGTVNIDLKSGNTINSWIEYDGLTRVFNVSVSYS----NLKPKVPILSFPLDLDRYVNDFMFVGFSGSTQGSTEIHSIEWWSFSSSFGSSLGSGSGSP---PPRANLMNPKANSVKSPPPLASQPSSSAIPISSNTQLKTSSSSSCHSRFCKENPGTIAGVVTAGAFFLALFAGALFWVYSKKFKR-----VERSDSFASEIIKAPKEFSYKELKAGTKNFNESRIIGHGAFGVVYRGILPETGDIVAVKRCSHSSQDKKNEFLSELSIIGSLRHRNLVRLQGWCHEKGEILLVYDLMPNGSLDKALFESRFTLPWDHRKKILLGVASALAYLHRECENQVIHRDVKSSNIMLDESFNAKLGDFGLARQIEHDK--SPEATVAAGTMGYLAPEYLLTGRASEKTDVFSYGAVVLEVVSGRRPIEKDLNVQRHNVGVNPNLVEWVWGLYKEGKVSAAADSRLEGKFDEGEMWRVLVVGLACSHPDPAFRPTMRSVVQMLIGEADVPVVPKS 663          

Query:    6 IVIIFLLQMITSTKPLSFHYQTFKY-DDVKLEGDAS-LLYSYIQLTSTTRYQSN---AYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDP-SGIHVGINLNSMMSQKTKPWL-IDIKNKKGY-YSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWK-RAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLY---RGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQ----VSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVYPTAISTIFD 651
            + +I   ++ T  K L F +  F   ++++L  D S +++  IQ+T           A   GR    +P  LW K   K   F T F   I +     G+GLAF L   E         G  LG+V++    N+ +   V+VEFDT ++  D   G HV +N+N++ S   +      IK   G   +  ++Y+     + VS   ++ + + +    S  +DL  YLPE V  GF+A+T    E+N ++SWSF                           K D   + +WL   + + I +I  +  +L  L  + R+K  + +   + ++D+       P++F   +L  AT NF    K+GQGGFG V+KG  +  D  +A+KR+S++S QG +E+  E+  I  L HRNLV+L+GWC+ +K++LL+YE+M NGSLD +L+   + +S LTW  R NI   L+ AL YLH   E+ +LHRDIK SN+MLD +FNAKLGDFGLAR++   +++   T  IAGT GY+APE F  G+AT E+D+Y+FG++ LE+VSG+KP  +  K++Q     SI +W+  LYR G + + AD  +  +FD+E+M+ ++++GL C +PN + RP ++ V++VL  E   P +P      V+P    +  D
Sbjct:   10 LFLILTCKIETQVKCLKFDFPGFNVSNELELIRDNSYIVFGAIQVTPDVTGGPGGTIANQAGRALYKKPFRLWSK--HKSATFNTTFVINISNKTDPGGEGLAFVLTPEETA--PQNSSGMWLGMVNERTNRNN-ESRIVSVEFDTRKSHSDDLDGNHVALNVNNINSVVQESLSGRGIKIDSGLDLTAHVRYDGKNLSVYVSRNLDVFEQRNL--VFSRAIDLSAYLPETVYVGFTASTSNFTELNCVRSWSFEGL------------------------KIDGDGNMLWLW--ITIPIVFIVGIGAFLGALYLRSRSKAGETNPDIEAELDN---CAANPQKFKLRELKRATGNFGAENKLGQGGFGMVFKGKWQGRD--IAVKRVSEKSHQGKQEFIAEITTIGNLNHRNLVKLLGWCYERKEYLLVYEYMPNGSLDKYLFLEDKSRSNLTWETRKNIITGLSQALEYLHNGCEKRILHRDIKASNVMLDSDFNAKLGDFGLARMIQQSEMTHHSTKEIAGTPGYMAPETFLNGRATVETDVYAFGVLMLEVVSGKKPSYVLVKDNQNNYNNSIVNWLWELYRNGTITDAADPGMGNLFDKEEMKSVLLLGLACCHPNPNQRPSMKTVLKVLTGETSPPDVPTERPAFVWPAMPPSFSD 633          

Query:   16 TSTKPLSFHYQTFKY--DDVKLEGDASLLYSYI-QLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSN-ETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPW--DPSGIHVGINLNSMMSQKTKP---W-LIDIKNKKGYYSCK-----IQYNSSVHDLKVSFT--GNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPK--PDSKKSTIWLRLGVG--VGIAWIFLV-LGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSL-LTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQ-VSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPIL 633
            +S++ L+F Y +F     ++ ++G A++  + I +LT  T       S G     EP+   D  +  ++ F+T F   IYS   T  G G+AFF+A P  P+L        LGL       N + +  +AVEFDT  NP   D +  HVGIN+NS+ S K+     W  I+  N     S K     + Y+   + + V+    G +   KP K+ +S   DL     + +  GFSAATG +   + +  WSF         V       L  S+ P  P+  P S +     R+ +   + I  +F+V L +L   I +R +   E+        ++++   G  R  +  L  AT  F++   +G GGFG VY+G +      +A+KR+S ES+QG+KE+  E+  I ++ HRNLV L+G+C  + + LL+Y++M NGSLD +LY    + L W  R+N+ + +AS L YLHEEWEQ V+HRDIK SN++LD  +N +LGDFGLARL DH   S  +TT + GT GY+AP++  TG+AT  +D+++FG++ LE+  GR+PI++  + D+ V + D V G +  G +L+  D  L  V+D+ ++E ++ +GL C++ +   RP +RQV+Q L+ +A LP L
Sbjct:   22 SSSQSLNFTYNSFHRPPTNISIQGIATVTSNGILKLTDKT-----VISTGHAFYTEPIRFKDSPNDTVSSFSTTFVIGIYSGIPTISGHGMAFFIA-PN-PVLSSAMASQYLGLFSSTNNGNDTNH-ILAVEFDTIMNPEFDDTNDNHVGININSLTSVKSSLVGYWDEINQFNNLTLISRKRMQVWVDYDDRTNQIDVTMAPFGEV---KPRKALVSVVRDLSSVFLQDMYLGFSAATGYVLSEHFVFGWSF--------MVKGKTAPPLTLSKVPKFPRVGPTSLQRFYKNRMPLFSLLLIPVLFVVSLIFLVRFIVRRRRKFAEEF-------EDWETEFGKNRLRFKDLYYATKGFKDKDLLGSGGFGRVYRGVMPTTKKEIAVKRVSNESRQGLKEFVAEIVSIGRMSHRNLVPLLGYCRRRDELLLVYDYMPNGSLDKYLYDCPEVTLDWKQRFNVIIGVASGLFYLHEEWEQVVIHRDIKASNVLLDAEYNGRLGDFGLARLCDHG--SDPQTTRVVGTWGYLAPDHVRTGRATTATDVFAFGVLLLEVACGRRPIEIEIESDESVLLVDSVFGFWIEGNILDATDPNLGSVYDQREVETVLKLGLLCSHSDPQVRPTMRQVLQYLRGDATLPDL 635          

Query:   77 SRKLTDFTTQFSF-IIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPW--DPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYY-------------------------SCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPS-NLE--PSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLY-RGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPIL 633
            S  +  F+T F   II + E     G+AF +A  +   L     G  +GLV+     N++ + F AVEFDT  N    D SG HVGI++N + S       +D  N  GYY                            +Q N ++  L+V+        +P K  +S  V++   + +    GFS+ATG++F  + +  WSF        K++ + P+ N+   PS     PKP SK  T+ + L +   +    +       +  +R   E         + +E++   GP RF Y  L  AT+ F + + +G GGFG VY+G L    + VA+K+++  S+QG++E+  EV  I +LRHRNLVQL+G+C  K + LL+Y++M NGSLD  LY +GK  L W  R+ I   +AS LLYLHE+WEQ V+HRDIK SN++LD + N +LGDFGLARL DH   +   TT + GTMGY+APE   TGKA+K SD+++FG   LE+  GRKP+   A++++V + DWVL  +R G + +  D +L G F E +   ++ +GL C++P    RP  RQ++Q L+ + PLP L
Sbjct:   83 STAMQSFSTAFVIGIIGAFEDLSSHGMAFIIAKSKN--LTSALPGQFMGLVNSANNGNATNHLF-AVEFDTILNSEFNDMSGNHVGIDVNGLNS-------VDADNA-GYYDDGTGDFKNMSLVSRRPMQVWVDFDGQTMQVNVTMAPLEVA--------RPKKPLLSKIVNISSVIDDTAYVGFSSATGILFCRHYVLGWSF--------KMNGAAPALNISSLPSLPVTFPKPRSK--TLEIVLPIASAVLVFAVAAAVFVFMRRRRMFSE---------LKEEWEVTFGPHRFSYKDLFHATDGFSDKRLLGIGGFGRVYRGVLPSSKAEVAVKKVAHGSRQGMREFVAEVVSIGRLRHRNLVQLLGYCRRKGELLLVYDYMPNGSLDKQLYDQGKITLRWAQRFRIIRGVASGLLYLHEDWEQVVVHRDIKASNVLLDADMNGRLGDFGLARLYDHG--TDPHTTHVVGTMGYLAPELGHTGKASKASDVFAFGAFMLEVACGRKPVAQDARDNRVVLVDWVLDRWRAGAITDTVDPRLHGDFVESEASLVLRLGLLCSHPLPGARPGTRQLVQYLEGDVPLPEL 631          

Query:   45 YIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNP--WDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCK------------------IQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKS--LLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLP 631
            Y  LT+TT++     + G+    E + + + ++  ++ F+  F F I       G     F+  P   L     +   LG+ +K     +S  + +A+E D H++    D    HVGIN+N + S  +           GYY  K                  I Y+     L V+     +   P+K  +S N DL  YL EK+  GF+A+TG +  ++ L  W  N  +E   ++  SIP        P  PK  S ++   L + + V +   F V  W+  + + R K  KE       + +E++   GP RF Y +L  AT  F+E Q +G+GGFG VYKG L   D+ +A+KR S +S+QG+ E+  E+  I +LRH NLV+L+G+C  K++  L+Y++M NGSLD +L R ++   LTW  R+ I  D+A+ALL+LH+EW Q ++HRDIK +N+++D   NA+LGDFGLA+L D  +    ET+ +AGT GYIAPE+  TG+AT  +D+Y+FG+V LE+V GR+ I+  A E++  + DW+L L+  GK+ + A+  +    +  Q+E ++ +G+ C++   S RP +  V+++L   + LP
Sbjct:   40 YFTLTNTTKH-----TFGQAFENEHVEIKNSSTGVISSFSVNFFFAIVPEHNQQGSHGMTFVISPTRGLPGASSDQY-LGIFNKTNNGKASN-NVIAIELDIHKDEEFGDIDDNHVGININGLRSVASA--------SAGYYDDKDGSFKKLSLISREVMRLSIVYSQPDQQLNVTLFPAEIPVPPLKPLLSLNRDLSPYLLEKMYLGFTASTGSVGAIHYLMGWLVNGVIEYP-RLELSIPV------LPPYPKKTSNRTKTVLAVCLTVSVFAAF-VASWIGFVFYLRHKKVKE-------VLEEWEIQYGPHRFAYKELFNATKGFKEKQLLGKGGFGQVYKGTLPGSDAEIAVKRTSHDSRQGMSEFLAEISTIGRLRHPNLVRLLGYCRHKENLYLVYDYMPNGSLDKYLNRSENQERLTWEQRFRIIKDVATALLHLHQEWVQVIIHRDIKPANVLIDNEMNARLGDFGLAKLYD--QGFDPETSKVAGTFGYIAPEFLRTGRATTSTDVYAFGLVMLEVVCGRRIIERRAAENEEYLVDWILELWENGKIFDAAEESIRQEQNRGQVELVLKLGVLCSHQAASIRPAMSVVMRILNGVSQLP 616          

Query:    9 IFLLQMITSTKPLSFHYQTFKYD--DVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGD---GLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNP-WDPSGI--HVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAK--EDQVSIFDWVLGLYRLGKLLEVADRKLE-GVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVY 642
            + +L  + S +   F+   F  D  ++  +GDA      ++LT+   Y   A   G  T  + + LW+  + K +DF+T+FSF I +   G+G+   G AFFLA   + L  +   GG LGL +      SS +  V VEFDT  NP WDP  +  HVGIN NS++S     W     N+       I Y+S+  +L VS+T ++       S +SY +DL   LP +V  GFSA +G + E N L SW F+SSLE                   +  K  + K  + + + V   +   F +   +  L  K+ K + E++     ++++ ++G GP++F Y  LA+A NNF + +K+G+GGFG VY+GYL  +D  VAIK+ +  SKQG +E+ TEVKIIS LRHRNLVQLIGWCH K +FL+IYEFM NGSLD+HL+  K  L W +R  I + LASALLYLHEEWEQCV+HRDIK SN+MLD NFNAKLGDFGLARL+DHE   Q  TT +AGT GY+APEY +TG+A+KESD+YSFG+V+LE+V+GRK +D      E   ++ + +  LY  G+++   D KL  G FDE+Q E L+++GLWCA+P+ + RP ++Q IQVL  EAP+P LP  M  + Y
Sbjct:   11 VLVLPFVCSVQ---FNISRFGSDVSEIAYQGDARA-NGAVELTNID-YTCRA---GWATYGKQVPLWNPGTSKPSDFSTRFSFRIDTRNVGYGNYGHGFAFFLAPARIQLPPN-SAGGFLGLFNGTNN-QSSAFPLVYVEFDTFTNPEWDPLDVKSHVGINNNSLVSSNYTSWNATSHNQD-IGRVLIFYDSARRNLSVSWTYDLTSDPLENSSLSYIIDLSKVLPSEVTIGFSATSGGVTEGNRLLSWEFSSSLE-----------------LIDIKKSQNDKKGMIIGISVSGFVLLTFFITSLIVFLKRKQQKKKAEETENLTSINEDLERGAGPRKFTYKDLASAANNFADDRKLGEGGFGAVYRGYLNSLDMMVAIKKFAGGSKQGKREFVTEVKIISSLRHRNLVQLIGWCHEKDEFLMIYEFMPNGSLDAHLFGKKPHLAWHVRCKITLGLASALLYLHEEWEQCVVHRDIKASNVMLDSNFNAKLGDFGLARLMDHELGPQ--TTGLAGTFGYMAPEYISTGRASKESDVYSFGVVTLEIVTGRKSVDRRQGRVEPVTNLVEKMWDLYGKGEVITAIDEKLRIGGFDEKQAECLMIVGLWCAHPDVNTRPSIKQAIQVLNLEAPVPHLPTKMPVATY 625          

Query:   28 FKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYS-NETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNP-WDPS--GIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCKIQYNSSVHDLKVSFTGNIVDGKPVK--SYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIA---WIFLVLGWLC-ILIWKR-AKGEKEDSIFDM-KMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLY-RGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAK-------EDQVSIFDWVLGLYRLGKLL-EVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILP 634
            F + D   + D ++ ++  + TS          VG +T  + + +W   + K +DF+T FSF I + N +  G G+ FFLA P    L     GG L L  +    +SS +  V VEFDT  NP WDP+  G HVGIN NS++S     W     + +     KI Y+S   +L V++   +      K  S +SY +DL   LP  V+FGF AA G   E + L SW  +SSL++D                    K DS       R+G+ +GI+   ++FL    +  +++W R  + +KE  I +M  ++ + ++  GP++F Y  L +ATN F   +K+G+GGFG VY+G LKEI++ VA+K++S +S+QG  E+  EVKIISKLRHRNLVQLIGWC+ K +FLLIYE + NGSL+SHL+ +  +LL+W +RY I + LASALLYLHEEW+QCVLHRDIK SNIMLD  FN KLGDFGLARL++HE  S   TT +AGT GY+APEY   G A+KESDIYSFGIV LE+V+GRK ++   +       +D+ S+ + V  LY   +L+    D KL   FD+++ E L+V+GLWCA+P+ + RP ++Q IQV+ FE+PLP LP
Sbjct:   52 FYHGDATPDEDGTVNFNNAEQTS---------QVGWITYSKKVPIWSHKTGKASDFSTSFSFKIDARNLSADGHGICFFLA-PMGAQLPAYSVGGFLNLFTRKNNYSSS-FPLVHVEFDTFNNPGWDPNDVGSHVGINNNSLVSSNYTSWNAS-SHSQDICHAKISYDSVTKNLSVTWAYELTATSDPKESSSLSYIIDLAKVLPSDVMFGFIAAAGTNTEEHRLLSWELSSSLDSD--------------------KADS-------RIGLVIGISASGFVFLTFMVITTVVVWSRKQRKKKERDIENMISINKDLEREAGPRKFSYKDLVSATNRFSSHRKLGEGGFGAVYEGNLKEINTMVAVKKLSGDSRQGKNEFLNEVKIISKLRHRNLVQLIGWCNEKNEFLLIYELVPNGSLNSHLFGKRPNLLSWDIRYKIGLGLASALLYLHEEWDQCVLHRDIKASNIMLDSEFNVKLGDFGLARLMNHELGSH--TTGLAGTFGYMAPEYVMKGSASKESDIYSFGIVLLEIVTGRKSLERTQEDNSDTESDDEKSLVEKVWELYGKQELITSCVDDKLGEDFDKKEAECLLVLGLWCAHPDKNSRPSIKQGIQVMNFESPLPDLP 638          

Query:   14 MITSTKPLSFHYQTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYS---NETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPW--DPSGIHVGINLNSMMSQKTK-PWL---IDIKNKKGYYSCKIQYNSSVHDLKV--SFTGNIVDGK-PVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSS--------LENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYR----GKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQ-VSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFE---APLP 631
            +  S+  ++F +++F   ++   GD+ L    + LT          S G V    P+  +D  S     F+T FSF + +   + T  GDGLAFFL+     L      GG LGLV+  Q +   +  FVA+EFDT  +P   DP+G H+G++++S+ S  T  P L   ID+K+ K   S  I Y + +  L V  S+T  +   K P K  +S N+DL  +L  ++  GFS +T    E++ +++WSF +S          +   VS S   N +P   P+  +       I L +   V I     V G+  +  WK  K EKE       +  E    TG + F Y +L TAT  F  ++ IG+G FG VY+       +  A+KR    S +G  E+  E+ II+ LRH+NLVQL GWC+ K + LL+YEFM NGSLD  LY+    G   L W  R NIA+ LASAL YLH E EQ V+HRDIKTSNIMLD NFNA+LGDFGLARL +H+K     +T+ AGTMGY+APEY   G AT+++D +S+G+V LE+  GR+PID   +  + V++ DWV  L+  G++LE  D +L+G FDEE M++L+++GL CA+P+ + RP +R+V+Q+L  E   +P+P
Sbjct:   24 IFVSSDNMNFTFKSFTIRNLTFLGDSHLRNGVVGLTRELGVPDT--SSGTVIYNNPIRFYDPDSNTTASFSTHFSFTVQNLNPDPTSAGDGLAFFLSHDNDTL---GSPGGYLGLVNSSQPM---KNRFVAIEFDTKLDPHFNDPNGNHIGLDVDSLNSISTSDPLLSSQIDLKSGKSITSW-IDYKNDLRLLNVFLSYTDPVTTTKKPEKPLLSVNIDLSPFLNGEMYVGFSGSTEGSTEIHLIENWSFKTSGFLPVRSKSNHLHNVSDSSVVNDDPVVIPSKKRRHRHNLAIGLGISCPVLICLALFVFGYFTLKKWKSVKAEKE-------LKTELI--TGLREFSYKELYTATKGFHSSRVIGRGAFGNVYRAMFVSSGTISAVKRSRHNSTEGKTEFLAELSIIACLRHKNLVQLQGWCNEKGELLLVYEFMPNGSLDKILYQESQTGAVALDWSHRLNIAIGLASALSYLHHECEQQVVHRDIKTSNIMLDINFNARLGDFGLARLTEHDKSPV--STLTAGTMGYLAPEYLQYGTATEKTDAFSYGVVILEVACGRRPIDKEPESQKTVNLVDWVWRLHSEGRVLEAVDERLKGEFDEEMMKKLLLVGLKCAHPDSNERPSMRRVLQILNNEIEPSPVP 649          

Query:   14 MITSTKPLSFHYQTFK--YDDVKLEGDASLL-YSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSN-ETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNP--WDPSGIHVGINLNSMMSQK--TKPWLID---IKNKKGYYSCKIQ----YNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVG-VGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRG-KSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLY-AKEDQVSIFDWVLGLYRLGKLLEVADRKL-EGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPIL 633
            MI+S++ L+F Y  F     D+ L+G A++     ++LT+T+  ++     G   C E +   D  +  ++ F+T F F I+S   T  G G+AF +A P L L   +     +GL +     N + + F AVEFDT Q+    DP+  HVGI+LN + S    T  +  D    +N       +IQ    Y++  H + V+      D KP K  +SY  DL   L E +  GFS+ATG +   + L  WSF        +++   P  L  S+ P  P+ + ++ + + ++G+  + ++ IF ++ +L   I +R K  +E+        D+++   G  RF + +L  AT  F+E   +G GGFG VY+G L      VA+KR+S +SKQG+KE+  E+  I ++ HRNLV L+G+C  + + LL+Y++M NGSLD +LY   ++ L W  R  I   +AS L YLHEEWEQ V+HRD+K SN++LD +FN +LGDFGLARL DH   S  +TT + GT+GY+APE+  TG+AT  +D+Y+FG   LE+VSGR+PI+ + A +D   + +WV  L+  G ++E  D KL    +D E++E ++ +GL C++ +   RP +RQV+Q L+ +  LP L
Sbjct:   18 MISSSQNLNFTYNGFHPPLTDISLQGLATVTPNGLLKLTNTSVQKT-----GHAFCTERIRFKDSQNGNVSSFSTTFVFAIHSQIPTLSGHGIAFVVA-PTLGLPFALPSQY-IGLFNISNNGNDTNHIF-AVEFDTIQSSEFGDPNDNHVGIDLNGLRSANYSTAGYRDDHDKFQNLSLISRKRIQVWIDYDNRSHRIDVTVAPFDSD-KPRKPLVSYVRDLSSILLEDMYVGFSSATGSVLSEHFLVGWSF--------RLNGEAPM-LSLSKLPKLPRFEPRRISEFYKIGMPLISLSLIFSII-FLAFYIVRRKKKYEEEL-------DDWETEFGKNRFRFKELYHATKGFKEKDLLGSGGFGRVYRGILPTTKLEVAVKRVSHDSKQGMKEFVAEIVSIGRMSHRNLVPLLGYCRRRGELLLVYDYMPNGSLDKYLYNNPETTLDWKQRSTIIKGVASGLFYLHEEWEQVVIHRDVKASNVLLDADFNGRLGDFGLARLYDHG--SDPQTTHVVGTLGYLAPEHSRTGRATTTTDVYAFGAFLLEVVSGRRPIEFHSASDDTFLLVEWVFSLWLRGNIMEAKDPKLGSSGYDLEEVEMVLKLGLLCSHSDPRARPSMRQVLQYLRGDMALPEL 628          

Query:   83 FTTQFSFIIYSN-ETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPW--DPSGIHVGINLNSMMSQKTKP--WLIDIKNKKGYY-------SCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIA---WIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLY--RGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLP-ILPQNMF 638
            F+T F+  +     T  G GLAF  A    P L        LGL++  ++  SS   F AVEFDT ++    D +  HVGI++NSM S  + P  + +    KK  +          I Y+S+   L V  +      KP  S +SY+VDL   L +++  GFSA+TGL+   + +  W+FN S    E  S S+PS       P  P    K+      L +GV +     IF VL    + + ++ K   ED + + ++D       GP RF Y +L  ATN F + + +G GGFG VYKG L   D  VA+KRIS ES+QG++E+ +EV  I  LRHRNLVQL+GWC  + D LL+Y+FM NGSLD +L+    + +LTW  R+ I   +AS LLYLHE WEQ V+HRDIK +N++LD   N ++GDFGLA+L +H   S    T + GT GY+APE   +GK T  +D+Y+FG V LE+  GR+PI+  A  +++ + DWV   ++ G + +V DR+L G FDEE++  ++ +GL C+N +   RP +RQV+  L+ + P P ++P   F
Sbjct:   84 FSTSFAIAMVPEFVTLGGHGLAF--AITPTPDLRGSLPSQYLGLLNSSRVNFSSH--FFAVEFDTVRDLEFEDINDNHVGIDINSMESSISTPAGYFLANSTKKELFLDGGRVIQAWIDYDSNKKRLDVKLSP--FSEKPKLSLLSYDVDLSSVLGDEMYVGFSASTGLLASSHYILGWNFNMS---GEAFSLSLPS------LPRIPSSIKKRKKKRQSLILGVSLLCSLLIFAVLVAASLFVVRKVK--DEDRVEEWELD------FGPHRFSYRELKKATNGFGDKELLGSGGFGKVYKGKLPGSDEFVAVKRISHESRQGVREFMSEVSSIGHLRHRNLVQLLGWCRRRDDLLLVYDFMPNGSLDMYLFDENPEVILTWKQRFKIIKGVASGLLYLHEGWEQTVIHRDIKAANVLLDSEMNGRVGDFGLAKLYEHG--SDPGATRVVGTFGYLAPELTKSGKLTTSTDVYAFGAVLLEVACGRRPIETSALPEELVMVDWVWSRWQSGDIRDVVDRRLNGEFDEEEVVMVIKLGLLCSNNSPEVRPTMRQVVMYLEKQFPSPEVVPAPDF 632          

Query:    8 IIFLLQMITSTKPLSFHYQTFKYDDVKLEGDASLLYSYIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYS-NETGFGDGLAFFLADPELPLLDHMK-EGGGLGLVDKYQILNSSQYSFVAVEFDTHQNP--WDPSGIHVGINLNSMMSQKTKPW-LIDIKNKKG-YYSCKIQYN--SSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLG----------------------------------VGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGT--GPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPI--DLYAKEDQVSI----FDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQN 636
            I  LL          F + T    ++KL GDA L    + LT      ++    G+V    P+      +   T F++ FSF I + N +  G GLAF ++    P  + +   GG LGL       N S   FVAVEFDT  +    D +  HVG ++N ++S  +     ++I  K G   +  I+Y+  + V ++ VS++    + KP    +S+ +DL  Y+ + +  GFS +T    E+++++ WSF+SS  +     S  P    P     +PK +S KS   L                                      GV  A  F +  +   L W  +K  K      ++  D F       PK F Y +L   T NF E++ IG G FG VY+G L E    VA+KR S  S+    E+ +E+ II  LRHRNLV+L GWCH K + LL+Y+ M NGSLD  L+  +  L W  R  I + +ASAL YLH E E  V+HRD+K+SNIMLD +FNAKLGDFGLAR ++H+K    E TV AGTMGY+APEY  TG+A++++D++S+G V LE+VSGR+PI  DL  +   V +     +WV GLY+ GK+   AD +LEG FDE +M R++V+GL C++P+ +FRP +R V+Q+L  EA +P++P++
Sbjct:    9 ISILLCFFNGATTTQFDFSTLAISNLKLLGDARLSNGIVGLTRDLSVPNSG--AGKVLYSNPIRFRQPGTHFPTSFSSFFSFSITNVNPSSIGGGLAFVIS----PDANSIGIAGGSLGLTGP----NGSGSKFVAVEFDTLMDVDFKDINSNHVGFDVNGVVSSVSGDLGTVNIDLKSGNTINSWIEYDGLTRVFNVSVSYS----NLKPKVPILSFPLDLDRYVNDFMFVGFSGSTQGSTEIHSIEWWSFSSSFGSSLGSGSGSP---PPRANLMNPKANSVKSPPPLASQPSSSAIPISSNTQLKTSSSSSCHSRFCKENPGTIAGVVTAGAFFLALFAGALFWVYSKKFKR-----VERSDSFASEIIKAPKEFSYKELKAGTKNFNESRIIGHGAFGVVYRGILPETGDIVAVKRCSHSSQDKKNEFLSELSIIGSLRHRNLVRLQGWCHEKGEILLVYDLMPNGSLDKALFESRFTLPWDHRKKILLGVASALAYLHRECENQVIHRDVKSSNIMLDESFNAKLGDFGLARQIEHDK--SPEATVAAGTMGYLAPEYLLTGRASEKTDVFSYGAVVLEVVSGRRPIEKDLNVQRHNVGVNPNLVEWVWGLYKEGKVSAAADSRLEGKFDEGEMWRVLVVGLACSHPDPAFRPTMRSVVQMLIGEADVPVVPKS 663          

Query:    6 IVIIFLLQMITSTKPLSFHYQTFKY-DDVKLEGDAS-LLYSYIQLTSTTRYQSN---AYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDP-SGIHVGINLNSMMSQKTKPWL-IDIKNKKGY-YSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWK-RAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLY---RGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQ----VSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVYPTAISTIFD 651
            + +I   ++ T  K L F +  F   ++++L  D S +++  IQ+T           A   GR    +P  LW K   K   F T F   I +     G+GLAF L   E         G  LG+V++    N+ +   V+VEFDT ++  D   G HV +N+N++ S   +      IK   G   +  ++Y+     + VS   ++ + + +    S  +DL  YLPE V  GF+A+T    E+N ++SWSF                           K D   + +WL   + + I +I  +  +L  L  + R+K  + +   + ++D+       P++F   +L  AT NF    K+GQGGFG V+KG  +  D  +A+KR+S++S QG +E+  E+  I  L HRNLV+L+GWC+ +K++LL+YE+M NGSLD +L+   + +S LTW  R NI   L+ AL YLH   E+ +LHRDIK SN+MLD +FNAKLGDFGLAR++   +++   T  IAGT GY+APE F  G+AT E+D+Y+FG++ LE+VSG+KP  +  K++Q     SI +W+  LYR G + + AD  +  +FD+E+M+ ++++GL C +PN + RP ++ V++VL  E   P +P      V+P    +  D
Sbjct:   10 LFLILTCKIETQVKCLKFDFPGFNVSNELELIRDNSYIVFGAIQVTPDVTGGPGGTIANQAGRALYKKPFRLWSK--HKSATFNTTFVINISNKTDPGGEGLAFVLTPEETA--PQNSSGMWLGMVNERTNRNN-ESRIVSVEFDTRKSHSDDLDGNHVALNVNNINSVVQESLSGRGIKIDSGLDLTAHVRYDGKNLSVYVSRNLDVFEQRNL--VFSRAIDLSAYLPETVYVGFTASTSNFTELNCVRSWSFEGL------------------------KIDGDGNMLWLW--ITIPIVFIVGIGAFLGALYLRSRSKAGETNPDIEAELDN---CAANPQKFKLRELKRATGNFGAENKLGQGGFGMVFKGKWQGRD--IAVKRVSEKSHQGKQEFIAEITTIGNLNHRNLVKLLGWCYERKEYLLVYEYMPNGSLDKYLFLEDKSRSNLTWETRKNIITGLSQALEYLHNGCEKRILHRDIKASNVMLDSDFNAKLGDFGLARMIQQSEMTHHSTKEIAGTPGYMAPETFLNGRATVETDVYAFGVLMLEVVSGKKPSYVLVKDNQNNYNNSIVNWLWELYRNGTITDAADPGMGNLFDKEEMKSVLLLGLACCHPNPNQRPSMKTVLKVLTGETSPPDVPTERPAFVWPAMPPSFSD 633          

Query:    6 IVIIFLLQMITSTKPLSFHYQTFKY-DDVKLEGDAS-LLYSYIQLTSTTRYQSN---AYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPWDP-SGIHVGINLNSMMSQKTKPWL-IDIKNKKGY-YSCKIQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWK-RAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLY---RGKSLLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQ----VSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPILPQNMFESVYPTAISTIFD 651
            + +I   ++ T  K L F +  F   ++++L  D S +++  IQ+T           A   GR    +P  LW K   K   F T F   I +     G+GLAF L   E         G  LG+V++    N+ +   V+VEFDT ++  D   G HV +N+N++ S   +      IK   G   +  ++Y+     + VS   ++ + + +    S  +DL  YLPE V  GF+A+T    E+N ++SWSF                           K D   + +WL   + + I +I  +  +L  L  + R+K  + +   + ++D+       P++F   +L  AT NF    K+GQGGFG V+KG  +  D  +A+KR+S++S QG +E+  E+  I  L HRNLV+L+GWC+ +K++LL+YE+M NGSLD +L+   + +S LTW  R NI   L+ AL YLH   E+ +LHRDIK SN+MLD +FNAKLGDFGLAR++   +++   T  IAGT GY+APE F  G+AT E+D+Y+FG++ LE+VSG+KP  +  K++Q     SI +W+  LYR G + + AD  +  +FD+E+M+ ++++GL C +PN + RP ++ V++VL  E   P +P      V+P    +  D
Sbjct:   22 LFLILTCKIETQVKCLKFDFPGFNVSNELELIRDNSYIVFGAIQVTPDVTGGPGGTIANQAGRALYKKPFRLWSK--HKSATFNTTFVINISNKTDPGGEGLAFVLTPEETA--PQNSSGMWLGMVNERTNRNN-ESRIVSVEFDTRKSHSDDLDGNHVALNVNNINSVVQESLSGRGIKIDSGLDLTAHVRYDGKNLSVYVSRNLDVFEQRNL--VFSRAIDLSAYLPETVYVGFTASTSNFTELNCVRSWSFEGL------------------------KIDGDGNMLWLW--ITIPIVFIVGIGAFLGALYLRSRSKAGETNPDIEAELDN---CAANPQKFKLRELKRATGNFGAENKLGQGGFGMVFKGKWQGRD--IAVKRVSEKSHQGKQEFIAEITTIGNLNHRNLVKLLGWCYERKEYLLVYEYMPNGSLDKYLFLEDKSRSNLTWETRKNIITGLSQALEYLHNGCEKRILHRDIKASNVMLDSDFNAKLGDFGLARMIQQSEMTHHSTKEIAGTPGYMAPETFLNGRATVETDVYAFGVLMLEVVSGKKPSYVLVKDNQNNYNNSIVNWLWELYRNGTITDAADPGMGNLFDKEEMKSVLLLGLACCHPNPNQRPSMKTVLKVLTGETSPPDVPTERPAFVWPAMPPSFSD 645          

Query:   16 TSTKPLSFHYQTFKY--DDVKLEGDASLLYSYI-QLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSN-ETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNPW--DPSGIHVGINLNSMMSQKTKP---W-LIDIKNKKGYYSCK-----IQYNSSVHDLKVSFT--GNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPK--PDSKKSTIWLRLGVG--VGIAWIFLV-LGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKSL-LTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQ-VSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLPIL 633
            +S++ L+F Y +F     ++ ++G A++  + I +LT  T       S G     EP+   D  +  ++ F+T F   IYS   T  G G+AFF+A P  P+L        LGL       N + +  +AVEFDT  NP   D +  HVGIN+NS+ S K+     W  I+  N     S K     + Y+   + + V+    G +   KP K+ +S   DL     + +  GFSAATG +   + +  WSF         V       L  S+ P  P+  P S +     R+ +   + I  +F+V L +L   I +R +   E+        ++++   G  R  +  L  AT  F++   +G GGFG VY+G +      +A+KR+S ES+QG+KE+  E+  I ++ HRNLV L+G+C  + + LL+Y++M NGSLD +LY    + L W  R+N+ + +AS L YLHEEWEQ V+HRDIK SN++LD  +N +LGDFGLARL DH   S  +TT + GT GY+AP++  TG+AT  +D+++FG++ LE+  GR+PI++  + D+ V + D V G +  G +L+  D  L  V+D+ ++E ++ +GL C++ +   RP +RQV+Q L+ +A LP L
Sbjct:   22 SSSQSLNFTYNSFHRPPTNISIQGIATVTSNGILKLTDKT-----VISTGHAFYTEPIRFKDSPNDTVSSFSTTFVIGIYSGIPTISGHGMAFFIA-PN-PVLSSAMASQYLGLFSSTNNGNDTNH-ILAVEFDTIMNPEFDDTNDNHVGININSLTSVKSSLVGYWDEINQFNNLTLISRKRMQVWVDYDDRTNQIDVTMAPFGEV---KPRKALVSVVRDLSSVFLQDMYLGFSAATGYVLSEHFVFGWSF--------MVKGKTAPPLTLSKVPKFPRVGPTSLQRFYKNRMPLFSLLLIPVLFVVSLIFLVRFIVRRRRKFAEEF-------EDWETEFGKNRLRFKDLYYATKGFKDKDLLGSGGFGRVYRGVMPTTKKEIAVKRVSNESRQGLKEFVAEIVSIGRMSHRNLVPLLGYCRRRDELLLVYDYMPNGSLDKYLYDCPEVTLDWKQRFNVIIGVASGLFYLHEEWEQVVIHRDIKASNVLLDAEYNGRLGDFGLARLCDHG--SDPQTTRVVGTWGYLAPDHVRTGRATTATDVFAFGVLLLEVACGRRPIEIEIESDESVLLVDSVFGFWIEGNILDATDPNLGSVYDQREVETVLKLGLLCSHSDPQVRPTMRQVLQYLRGDATLPDL 635          

Query:   45 YIQLTSTTRYQSNAYSVGRVTCFEPLHLWDKTSRKLTDFTTQFSFIIYSNETGFGDGLAFFLADPELPLLDHMKEGGGLGLVDKYQILNSSQYSFVAVEFDTHQNP--WDPSGIHVGINLNSMMSQKTKPWLIDIKNKKGYYSCK------------------IQYNSSVHDLKVSFTGNIVDGKPVKSYMSYNVDLRDYLPEKVIFGFSAATGLMFEMNTLKSWSFNSSLENDEKVSSSIPSNLEPSRTPNSPKPDSKKSTIWLRLGVGVGIAWIFLVLGWLCILIWKRAKGEKEDSIFDMKMDDEFQKGTGPKRFCYNKLATATNNFEETQKIGQGGFGGVYKGYLKEIDSNVAIKRISKESKQGIKEYATEVKIISKLRHRNLVQLIGWCHMKKDFLLIYEFMQNGSLDSHLYRGKS--LLTWGMRYNIAMDLASALLYLHEEWEQCVLHRDIKTSNIMLDYNFNAKLGDFGLARLVDHEKVSQLETTVIAGTMGYIAPEYFTTGKATKESDIYSFGIVSLELVSGRKPIDLYAKEDQVSIFDWVLGLYRLGKLLEVADRKLEGVFDEEQMERLVVIGLWCANPNYSFRPCVRQVIQVLKFEAPLP 631
            Y  LT+TT++     + G+    E + + + ++  ++ F+  F F I       G     F+  P   L     +   LG+ +K     +S  + +A+E D H++    D    HVGIN+N + S  +           GYY  K                  I Y+     L V+     +   P+K  +S N DL  YL EK+  GF+A+TG +  ++ L  W  N  +E   ++  SIP        P  PK  S ++   L + + V +   F V  W+  + + R K  KE       + +E++   GP RF Y +L  AT  F+E Q +G+GGFG VYKG L   D+ +A+KR S +S+QG+ E+  E+  I +LRH NLV+L+G+C  K++  L+Y++M NGSLD +L R ++   LTW  R+ I  D+A+ALL+LH+EW Q ++HRDIK +N+++D   NA+LGDFGLA+L D  +    ET+ +AGT GYIAPE+  TG+AT  +D+Y+FG+V LE+V GR+ I+  A E++  + DW+L L+  GK+ + A+  +    +  Q+E ++ +G+ C++   S RP +  V+++L   + LP
Sbjct:   40 YFTLTNTTKH-----TFGQAFENEHVEIKNSSTGVISSFSVNFFFAIVPEHNQQGSHGMTFVISPTRGLPGASSDQY-LGIFNKTNNGKASN-NVIAIELDIHKDEEFGDIDDNHVGININGLRSVASA--------SAGYYDDKDGSFKKLSLISREVMRLSIVYSQPDQQLNVTLFPAEIPVPPLKPLLSLNRDLSPYLLEKMYLGFTASTGSVGAIHYLMGWLVNGVIEYP-RLELSIPV------LPPYPKKTSNRTKTVLAVCLTVSVFAAF-VASWIGFVFYLRHKKVKE-------VLEEWEIQYGPHRFAYKELFNATKGFKEKQLLGKGGFGQVYKGTLPGSDAEIAVKRTSHDSRQGMSEFLAEISTIGRLRHPNLVRLLGYCRHKENLYLVYDYMPNGSLDKYLNRSENQERLTWEQRFRIIKDVATALLHLHQEWVQVIIHRDIKPANVLIDNEMNARLGDFGLAKLYD--QGFDPETSKVAGTFGYIAPEFLRTGRATTSTDVYAFGLVMLEVVCGRRIIERRAAENEEYLVDWILELWENGKIFDAAEESIRQEQNRGQVELVLKLGVLCSHQAASIRPAMSVVMRILNGVSQLP 616