Ca_03715, Ca_03715_v1.0_kabuli (mRNA) Cicer arietinum

Query:  142 SASAQDLRDMDLEKEKEDEGSPRGVLEACVR-------GFESKQPP-----------ELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHPIG---VPKIPKWKSKSTREN-FVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            SASA DLR ++++KEK+D  SPRG LEAC+           S  PP           + +  C N RA S+WG                F P+     P I + KS     N  V+ ++++ +SSL  FS+SD+  AT+NFS EN+IGRGG+A+VY+G L +G+LIAV            A FLSELGIIAHVDHPNTAK IGC ++G MHLVF LS LGSLGS+LHG  K KL WS+RY VALG ADGL+YLHE CQRRIIHRDIKA+NILLTEDF+PQICDFGLAKWLP+QLTHHNVS FEGTFGYFAPEY+MHGIVDEKTDV++FGVLLLE+ITG  ALD  ++S+V+WAKPLL+   +K+LVDPSLGD Y++ ++  +  TAS+C++QS +LRPRM+Q
Sbjct:    3 SASAHDLRLLEVDKEKQDPKSPRGALEACLTRCSISSASSSSDDPPPNREAIDNADADTDVQCKNHRASSNWGKFFKLWKRRSMKRLSSFPPLSGAAPPIIKQNKSADPNMNGMVLHDIYDFQSSLQNFSISDIEIATDNFSPENIIGRGGYADVYQGILPEGKLIAVKRLTKGTPDEQTAEFLSELGIIAHVDHPNTAKFIGCCIEGGMHLVFRLSPLGSLGSLLHGPSKYKLTWSRRYNVALGTADGLVYLHEGCQRRIIHRDIKADNILLTEDFQPQICDFGLAKWLPKQLTHHNVSKFEGTFGYFAPEYFMHGIVDEKTDVFAFGVLLLELITGHPALDESQQSLVLWAKPLLERKAIKELVDPSLGDEYNREELIRLTSTASLCIDQSSLLRPRMSQ 404          

Query: 1283 QVVTLLRG-EDSILSTKASKRRPFQRTYSEEILDAQEYNSTKYLRDLNR 1426
            QVV LL G ED +++ + +K +  QRTYSEE+LD+ EYNSTKYL DL+R
Sbjct:  404 QVVELLLGHEDVVMTPREAKIKMMQRTYSEELLDSVEYNSTKYLGDLDR 452          

Query:  373 PKIPKWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXX--AGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALD-HMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            PK+   +S  T E F M+     + S   F+  +L  AT+ F+ EN+IG+GG AEVYKG L +G+ +A+              + FLSELGIIAHV+HPN A+L G   D  +H V E +  GSL S+L GS++C L+W  RYKVALGIADGL YLH  C RRIIHRDIKA NILL  D+E QI DFGLAKWLPE   HH V   EGTFGY APEY+MHGIVDEK DV++FGVLLLEIIT RRA+D   ++S+V WAKP L+ N+M+D+VDP LG+ ++  +M  V+LTASMCV     +RP M +
Sbjct:  117 PKLTPSESAFTCEAFFMA-----KPSWRNFTYEELAVATDYFNPENMIGKGGHAEVYKGVLINGETVAIKKLMSHAKEEEERVSDFLSELGIIAHVNHPNAARLRGFSSDRGLHFVLEYAPYGSLASMLFGSEEC-LEWKIRYKVALGIADGLSYLHNACPRRIIHRDIKASNILLNHDYEAQISDFGLAKWLPENWPHHVVFPIEGTFGYLAPEYFMHGIVDEKIDVFAFGVLLLEIITSRRAVDTASRQSIVAWAKPFLEKNSMEDIVDPRLGNMFNPTEMQRVMLTASMCVHHIAAMRPDMTR 416          

Query: 1283 QVVTLLRGEDSILSTKASKRRPFQRTYSEEILDAQEYNSTKYLRDLNRH 1429
            ++V LLRGED     +   ++  +RT S    D Q++ S+ YL +L RH
Sbjct:  416 RLVQLLRGEDGPAELQ---QKAGERTMSVNACDLQDHTSSSYLNELRRH 461          

Query:  385 KWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAG-FLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            KW+   T+      N    +  +  F+ +++ KATN+F   N++G GG++EVY+G L DG+ IAV               FL+ELGII+HV HPNTA L+GC V+  ++LVF  S  G+L S LH ++   LDW  RYK+A+G+A GL YLH+ C  RIIHRDIK+ N+LL  D+EPQI DFGLAKWLP + THH V   EGTFGY APE  M G +DEKTD+Y+FG+LLLEIITGRR ++  +K +++WAKP ++  N  +LVDP L D YD +QM  +VLTAS CV+QSPILRP M Q
Sbjct:  236 KWRGSETK------NKPKPQPLIQCFTYNEISKATNDFHQGNIVGIGGYSEVYRGDLWDGRRIAVKRLAKESGDMNKEKEFLTELGIISHVSHPNTALLLGCCVEKGLYLVFRFSENGTLYSALHENENGSLDWPVRYKIAVGVARGLHYLHKRCNHRIIHRDIKSSNVLLGPDYEPQITDFGLAKWLPNKWTHHAVIPVEGTFGYLAPESLMQGTIDEKTDIYAFGILLLEIITGRRPVNPTQKHILLWAKPAMETGNTSELVDPKLQDKYDDQQMNKLVLTASHCVQQSPILRPTMTQ 529          

Query:  457 TFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIG-CGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVST-FEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALD----HMKKSVVIWAKPLL----DANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQAS 1287
            TF+  +L +ATN FS  NL+G+GGF  V+KG L++G+ +AV              F +E+GII+ V H +   L+G C  D +  LV+E     +L   LHG  +  ++WS R K+A+G A GL YLHENC  +IIHRDIKA NIL+   FE ++ DFGLAK   +  TH  VST   GTFGY APEY   G + EK+DV+SFGV+LLE+ITGRR +D    H   S+V WA+PLL    +  N + +VD  L + YD+ +M  +V  A+ CV  +   RPRM+Q +
Sbjct:  341 TFNYEELSRATNGFSEANLLGQGGFGYVFKGMLRNGKEVAVKQLKEGSSQGERE-FQAEVGIISRVHHRHLVALVGYCIADAQRLLVYEFVPNNTLEFHLHGKGRPTMEWSSRLKIAVGSAKGLSYLHENCNPKIIHRDIKASNILIDFKFEAKVADFGLAKIASDTNTH--VSTRVMGTFGYLAPEYASSGKLTEKSDVFSFGVVLLELITGRRPIDVNNVHADNSLVDWARPLLNQVSELGNFEVVVDKKLNNEYDKEEMARMVACAAACVRSTAPRRPRMDQVA 624          

Query:  388 WKSKSTRENFVMS-NVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDG-EMHLVFELSTLGSLGSVLHGSDKC--KLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKS----VVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            WK    R    M  +  +L   + +FSL  +  ATNNF + N IG GGF  VYKG+L DG +IAV              FL+E+G+I+ + HPN  KL GC V+G ++ LV+E     SL   L G  +   +LDW  R K+ +G+A GL YLHE  + +I+HRDIKA N+LL +   P+I DFGLAK L E+ + H  +   GTFGY APEY M G + +K DVYSFG++ LEI+ GR       K+    ++ W + L + NN+ +LVDP LG  Y++ +   ++  A MC    P  RP M++
Sbjct:  587 WKKGYLRSKSQMEKDFKSLELMIASFSLRQIKIATNNFDSANRIGEGGFGPVYKGKLFDGTIIAVKQLSTGSKQGNRE-FLNEIGMISALHHPNLVKLYGCCVEGGQLLLVYEFVENNSLARALFGPQETQLRLDWPTRRKICIGVARGLAYLHEESRLKIVHRDIKATNVLLDKQLNPKISDFGLAK-LDEEDSTHISTRIAGTFGYMAPEYAMRGHLTDKADVYSFGIVALEIVHGRSNKIERSKNNTFYLIDWVEVLREKNNLLELVDPRLGSEYNREEAMTMIQIAIMCTSSEPCERPSMSE 890          

Query:  394 SKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMH-LVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKS----VVIWAKPLL-DANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            ++S+  + +MS++     S+ TF+LS+L KAT+ FS + ++G GGF  VY+G ++DG  +AV              F++E+ +++ + H N  KLIG  ++G    L++EL   GS+ S LH      LDW  R K+ALG A GL YLHE+   R+IHRD KA N+LL +DF P++ DFGLA+   E   H +     GTFGY APEY M G +  K+DVYS+GV+LLE++TGRR +D  + S    +V WA+PLL +   ++ LVDP+L   Y+   M  V   ASMCV Q    RP M +
Sbjct:  315 ARSSGSDSLMSSMATCALSVKTFTLSELEKATDRFSAKRVLGEGGFGRVYQGSMEDGTEVAVKLLTRDNQNRDRE-FIAEVEMLSRLHHRNLVKLIGICIEGRTRCLIYELVHNGSVESHLHEGT---LDWDARLKIALGAARGLAYLHEDSNPRVIHRDFKASNVLLEDDFTPKVSDFGLAREATEGSQHISTRVM-GTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLTGRRPVDMSQPSGEENLVTWARPLLANREGLEQLVDPALAGTYNFDDMAKVAAIASMCVHQEVSHRPFMGE 611          

Query:  457 TFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDG-EMHLVFELSTLGSLGSVLHGSDKCKL--DWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVST-FEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVI----WAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMN 1278
            +F+L  + +ATNNF  EN IG GGF  VYKG L DG  IAV              F++E+G+I+ + HPN  KL GC ++G E+ LV+E     SL   L G++K +L  DWS R KV +GIA GL YLHE  + +I+HRDIKA N+LL      +I DFGLAK   E+ TH  +ST   GT GY APEY M G + +K DVYSFGV+ LEI++G+   ++  K   I    WA  L +  ++ +LVDP LG ++ +++   ++  A +C   SP LRP M+
Sbjct:  654 SFTLKQIKRATNNFDPENKIGEGGFGPVYKGVLADGMTIAVKQLSSKSKQGNRE-FVTEIGMISALQHPNLVKLYGCCIEGKELLLVYEYLENNSLARALFGTEKQRLHLDWSTRNKVCIGIAKGLAYLHEESRLKIVHRDIKATNVLLDLSLNAKISDFGLAKLDEEENTH--ISTRIAGTIGYMAPEYAMRGYLTDKADVYSFGVVCLEIVSGKSNTNYRPKEEFIYLLDWAYVLQEQGSLLELVDPDLGTSFSKKEAMRMLNIALLCTNPSPTLRPPMS 932          

Query:  457 TFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIG-CGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVST-FEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALD----HMKKSVVIWAKPLL----DANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            TF+  +L +ATN FS  NL+G+GGF  V+KG L  G+ +AV              F +E+ II+ V H +   LIG C    +  LV+E     +L   LHG  +  ++WS R K+ALG A GL YLHE+C  +IIHRDIKA NIL+   FE ++ DFGLAK   +  TH  VST   GTFGY APEY   G + EK+DV+SFGV+LLE+ITGRR +D    ++  S+V WA+PLL    +  + + L D  +G+ YD+ +M  +V  A+ CV  S   RPRM+Q
Sbjct:  267 TFTYEELSRATNGFSEANLLGQGGFGYVHKGILPSGKEVAVKQLKAGSGQGERE-FQAEVEIISRVHHRHLVSLIGYCMAGVQRLLVYEFVPNNNLEFHLHGKGRPTMEWSTRLKIALGSAKGLSYLHEDCNPKIIHRDIKASNILIDFKFEAKVADFGLAKIASDTNTH--VSTRVMGTFGYLAPEYAASGKLTEKSDVFSFGVVLLELITGRRPVDANNVYVDDSLVDWARPLLNRASEEGDFEGLADSKMGNEYDREEMARMVACAAACVRHSARRRPRMSQ 548          

Query:  457 TFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDG-EMHLVFELSTLGSLGSVLHGSDKCKL--DWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVST-FEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVI----WAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMN 1278
            +F+L  + +ATNNF  EN IG GGF  VYKG L DG  IAV              F++E+G+I+ + HPN  KL GC ++G E+ LV+E     SL   L G++K +L  DWS R K+ +GIA GL YLHE  + +I+HRDIKA N+LL      +I DFGLAK   ++ TH  +ST   GT GY APEY M G + +K DVYSFGV+ LEI++G+   ++  K   +    WA  L +  ++ +LVDP LG ++ +++   ++  A +C   SP LRP M+
Sbjct:  656 SFTLKQIKRATNNFDPENKIGEGGFGPVYKGVLADGMTIAVKQLSSKSKQGNRE-FVTEIGMISALQHPNLVKLYGCCIEGKELLLVYEYLENNSLARALFGTEKQRLHLDWSTRNKICIGIAKGLAYLHEESRLKIVHRDIKATNVLLDLSLNAKISDFGLAKLNDDENTH--ISTRIAGTIGYMAPEYAMRGYLTDKADVYSFGVVCLEIVSGKSNTNYRPKEEFVYLLDWAYVLQEQGSLLELVDPDLGTSFSKKEAMRMLNIALLCTNPSPTLRPPMS 934          

Query:  400 STRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHL-VFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMK----KSVVIWAKPL----LDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            S R     S    L +S   FS  +L+KATN FS ENL+G GGF  VYKG L DG+++AV              F +E+  ++ + H +   ++G  + G+  L +++  +   L   LHG +K  LDW+ R K+A G A GL YLHE+C  RIIHRDIK+ NILL ++F+ ++ DFGLA+   +  TH       GTFGY APEY   G + EK+DV+SFGV+LLE+ITGR+ +D  +    +S+V WA+PL    ++      L DP LG NY + +M  ++  A  CV      RPRM Q
Sbjct:  345 SKRSGSYQSQSGGLGNSKALFSYEELVKATNGFSQENLLGEGGFGCVYKGILPDGRVVAVKQLKIGGGQGDRE-FKAEVETLSRIHHRHLVSIVGHCISGDRRLLIYDYVSNNDLYFHLHG-EKSVLDWATRVKIAAGAARGLAYLHEDCHPRIIHRDIKSSNILLEDNFDARVSDFGLARLALDCNTHITTRVI-GTFGYMAPEYASSGKLTEKSDVFSFGVVLLELITGRKPVDTSQPLGDESLVEWARPLISHAIETEEFDSLADPKLGGNYVESEMFRMIEAAGACVRHLATKRPRMGQ 644          

Query:    1 MANGGDAHQLRYCLWNHKRSFASKSKEVPIVDALNLKPNTLGSLLAWSASAQDLRDMDLEKEKEDEGSPRGVLEACVRGFESKQPPELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHPIGVPKIPKWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQASCNTAKRGRQYPIY 1326
            MA  GD   +   LW HKRSFASKSK++             GSL A SASAQDLR+MDLEKEK+DE SPRGVLEACV+GF+++Q PE ETSCSNSRARSHWG                 H IGVPKIPKWKS+STRENFV SN++N RSSLVTFSLSDL  ATN+FS+ENLIGRGGF+EVYKG LQDGQLIAV            AGFLSELG+IAHVDHPNTAKL+GC V+GEMHLVFELSTLGSLG VLHGSDK KLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTE+F+PQICDFGLAKWLPEQLTHHN+STFEGTFGY +PEY MHGIVDEKTDVYSFGVLLLEIITGR+ALD M+ SVV WAKPLLDANN+KD+VDPSLG NYDQ QMGCV LTAS+CVEQSPILRPRM+Q    T  RG +  +Y
Sbjct:    1 MAIEGDFCPINQGLWKHKRSFASKSKKI-------------GSLFACSASAQDLRNMDLEKEKDDEASPRGVLEACVKGFDAQQLPEPETSCSNSRARSHWGKFFKLWKRKSVKRLTSIHSIGVPKIPKWKSRSTRENFVTSNLYNFRSSLVTFSLSDLRNATNHFSHENLIGRGGFSEVYKGCLQDGQLIAVKKMTTGSTDEKTAGFLSELGVIAHVDHPNTAKLVGCCVEGEMHLVFELSTLGSLGYVLHGSDKTKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTENFDPQICDFGLAKWLPEQLTHHNMSTFEGTFGYLSPEYCMHGIVDEKTDVYSFGVLLLEIITGRKALDRMQTSVVTWAKPLLDANNIKDVVDPSLGGNYDQGQMGCVSLTASICVEQSPILRPRMSQIV--TLLRGEKSVMY 427          

Query: 1283 QVVTLLRGEDSILSTKA-SKRRPFQRTYSEEILDAQEYNSTKYLRDLNRH 1429
            Q+VTLLRGE S++  +A SKRR  QRTYSEE+LDAQEYNSTKYLRDLNRH
Sbjct:  414 QIVTLLRGEKSVMYARACSKRRNLQRTYSEELLDAQEYNSTKYLRDLNRH 463          

Query:   22 HQLRYCLWNHKRSFASKSKEVPIVDALNLKPNTL-----------------GSLLAWSASAQDLRDMDLEKEKEDEGSPRGVLEACVRGFESK-QPPELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHP-IGVPKIPKWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQASCNTAKRGRQYPIYKSKQKKAFP 1353
            H+L  CL + K+S A+K K++ I +AL+L+ + L                  SL + S+SA DLR ++LEKEKE+  SPRGVLEAC++ F+S  Q  E + +CS +RARSHW                   P I VPKIPKWKSKS+REN V+S ++N RSS VTFSLS+L  ATNNFS+EN+IGRGGFAEVYKG LQDGQLIAV            AGFL ELG+IAHVDHPNTAKL+GC V+GEM LVFELSTLGSLGS+LHGSDK KLDWSKRYK+ALGIADGLLYLHE C RRIIHRDIKAENILLTE+FEPQICDFGLAKWLPEQ THH+VS FEGTFGYFAPEY+MHGIVDEKTDV+SFGVLLLEIITGR A+DHM++SVVIWAKPLLDAN++KDLVDPSLGD+Y + QMGCVVLTASMC+E SPILRPRM+Q    T  RG  + +  +K  +  P
Sbjct:    4 HKLDCCLCDQKKSQANKPKKLTIAEALDLQSDLLHPDTNANTRPKRATKRQASLFSCSSSAHDLRHLELEKEKENIASPRGVLEACMKDFDSHDQSHESKATCSTTRARSHWSKFFKIWRKKSFKRLGSLPPLISVPKIPKWKSKSSRENQVLSKLYNFRSSWVTFSLSELRNATNNFSDENIIGRGGFAEVYKGCLQDGQLIAVKKLSKGTTDEKTAGFLCELGVIAHVDHPNTAKLVGCCVEGEMQLVFELSTLGSLGSLLHGSDKKKLDWSKRYKIALGIADGLLYLHECCHRRIIHRDIKAENILLTENFEPQICDFGLAKWLPEQWTHHSVSKFEGTFGYFAPEYFMHGIVDEKTDVFSFGVLLLEIITGRPAVDHMQQSVVIWAKPLLDANHIKDLVDPSLGDDYKREQMGCVVLTASMCIEHSPILRPRMSQVV--TLLRGEDHVLKATKSSRRRP 464          

Query: 1283 QVVTLLRGEDSIL-STKASKRRPFQRTYSEEILDAQEYNSTKYLRDLNR 1426
            QVVTLLRGED +L +TK+S+RRP QR YSEE+LDAQEYNSTK+LRDL R
Sbjct:  442 QVVTLLRGEDHVLKATKSSRRRPLQRAYSEELLDAQEYNSTKHLRDLKR 490          

Query:   52 KRSFASKSKE-VPIVDALNLK-----------PNT----------------LGSLLAWSASAQDLRDMDLEKEKEDEGSPRGVLEACVRGF---ESKQPPELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHPIGVPKIPKWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQASCNTAKRGRQYPIYKSKQKKAFPKNIFR 1368
            K++ A+KSK+ + I +ALN +           PNT                  SL +  +SA DLR ++LEKEKED  SPR VLEA ++ F     +Q  E ET+ S ++   HW                   P+ VPK+PKWKSKS+REN  +S ++N RSS VTFSLS L  ATNNFS EN+IGRGGFAEVYKG LQ+GQLIAV            AGFL ELG+IAHVDHPNTAKL+GC V+GEM LVF+LSTLGSLGS+LHGSDK KLDWSKRYK+ LGIADGLLYLHE C RRIIHRDIKAENILLTE+FEPQICDFGLAKWLPEQ THHNVS FEGTFGYFAPEY+MHGIVDEKTDV+SFGVLLLEIITGR A+DHM++SVVIWAKPLLD N++KDLVDPSLGD+Y++ Q+ CVVLTASMC+E SPI RPRM+Q    T  RG  + + K+K+     +++ R
Sbjct:   62 KKNQANKSKKKLTIAEALNFESHMQHANPNPNPNTNTNTNANSRSKRATKRQASLFSCYSSAHDLRHLELEKEKEDSSSPREVLEAFMKDFVDSHHEQSHESETTSSTTKTHYHWTKFFKLWKKKSFKRLGSIPPLSVPKLPKWKSKSSRENQALSKLYNFRSSWVTFSLSKLRHATNNFSAENIIGRGGFAEVYKGCLQNGQLIAVKKLTKGTTDEKTAGFLCELGVIAHVDHPNTAKLVGCCVEGEMLLVFQLSTLGSLGSLLHGSDKNKLDWSKRYKICLGIADGLLYLHECCHRRIIHRDIKAENILLTENFEPQICDFGLAKWLPEQWTHHNVSKFEGTFGYFAPEYFMHGIVDEKTDVFSFGVLLLEIITGRPAVDHMQQSVVIWAKPLLDKNHIKDLVDPSLGDDYERGQLSCVVLTASMCIEHSPIFRPRMSQVV--TLLRGEDH-VLKAKKSSQSSRSLQR 528          

Query: 1283 QVVTLLRGEDSILSTKASKR--RPFQRTYSEEILDAQEYNSTKYLRDLNR 1426
            QVVTLLRGED +L  K S +  R  QRTYSEE+ DAQEYNSTK+LRDL R
Sbjct:  502 QVVTLLRGEDHVLKAKKSSQSSRSLQRTYSEELPDAQEYNSTKHLRDLKR 551          

Query:  157 DLRDMDLEKEKEDEGSPRGVLEACVRGFESKQP------PELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHPIGVPKIP-KWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQASCNTAKR 1305
            DLR +++EKEKED  +PRGVLE C+R FES+         E E  C NS +RSHW                 F P+GVPKI  + + +S REN  ++N++N +SSLVTF+ SDL +ATNNF+NEN IG+GG++EVYKG L++GQLIAV            AGFLSELGIIAHVDHPNTAKLIGC V+G MHLVFELS+LGSLGS+LHG    KLDWSKRYK+ALGIADGLLYLHE+CQRRIIHRDIKA+NILLTEDF PQICDFGLAKWLP+Q THHNVS  EGTFGYFAPEY+MHGIVDEKTDVYSFGVLLLE+I+GR ALD  +KSVVIWAKPLLD N +K+LVDPS+GDNYDQ++M  VVLTAS+C+EQS ILRPRM+QA+C T+KR
Sbjct:    5 DLRCLEIEKEKEDAQTPRGVLEVCIRSFESETSVSENGTTESEAPCPNSSSRSHWRKFFKSWSKRSIKRLASFPPLGVPKISSRRRIRSARENPGLANIYNFKSSLVTFTCSDLQRATNNFNNENTIGKGGYSEVYKGCLKNGQLIAVKRLTKGTSDEKTAGFLSELGIIAHVDHPNTAKLIGCCVEGGMHLVFELSSLGSLGSLLHGLKANKLDWSKRYKIALGIADGLLYLHESCQRRIIHRDIKADNILLTEDFVPQICDFGLAKWLPKQWTHHNVSKSEGTFGYFAPEYFMHGIVDEKTDVYSFGVLLLELISGRPALDDSQKSVVIWAKPLLDNNEIKELVDPSIGDNYDQKEMDHVVLTASLCIEQSSILRPRMSQANCGTSKR 394          

Query:  157 DLRDMDLEKEKEDEGSPRGVLEACVRGFESKQP----PELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHPIGVPKIPKWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHG----SDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQASCNTAKRGRQYPIYKSKQKK 1344
            DLR  D+E+E++D  SPRGV+EAC+ G ES          E+    S+A S+W                   P  VPK PK KS+STREN V+ N++N +S+L  F+ ++L  ATNNF++ENLIG+GGFAEVYKG L DG+L+A+            AGFL+ELGIIAHVDHPNTAKL+GCG+DG MHLVFELS LGSLGS LHG      + +LDWSKRYK+ALG ADGLLYLHENC+RRIIHRDIKA+NILLT++FEPQICDFGLAKWLP Q THHNVS FEGTFGYFAPEYYMHGIVDEKTD+Y+FGVLLLE+ITGRR +D +++S+V+WAKPLLD N+ K+L DPSLGDNYD  +M  VVLTAS+C+EQSP+LRPRM+QAS     RG +Y   ++K+ K
Sbjct:    1 DLRASDMERERQDGSSPRGVIEACLTGLESNSDFTRNSTAESEVPRSKAHSNWSRFFKSWKRFSLKHLTS--PPPVPKEPKRKSRSTRENTVLRNLYNFKSTLQHFTFAELKMATNNFNHENLIGKGGFAEVYKGCLPDGRLVAIKQLTKGTLDEKTAGFLNELGIIAHVDHPNTAKLLGCGIDGGMHLVFELSPLGSLGSALHGLVLICSQVELDWSKRYKIALGAADGLLYLHENCRRRIIHRDIKADNILLTKNFEPQICDFGLAKWLPTQWTHHNVSKFEGTFGYFAPEYYMHGIVDEKTDIYAFGVLLLELITGRRPVDRLQQSLVVWAKPLLDNNDTKELADPSLGDNYDLEEMDRVVLTASLCIEQSPVLRPRMSQASVVILLRGDEYVSERAKKGK 402          

Query:  109 KPNTLGSLLAWSASAQDLRDMDLEKEKEDEGSPRGVLEAC-----VRGFESKQPP-----------ELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHPIG--VPKIPKWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            K     + L  SASA DLR +++EKEK+D  SPRG LEAC     +    S  PP           + +  C N RA S+WG                F P+    P I K  +K+  +  V+ ++++ +SSL  FS+SD+  AT+NFS EN+IGRGG+AEVY+G L +G+LIAV            A FLSELGIIAHVDHPNTAK IGC ++G MHLVF LS LGSLGS+LHG  K KL WS+RY VALG ADGL+YLHE CQRRIIHRDIKA+NILLTEDF+PQICDFGLAKWLP+QLTHHNVS FEGTFGYFAPEY+MHGIVDEKTDV++FGVLLLE+ITG  ALD  ++S+V+WAKPLL+   +++LVDPSLGD Y++ ++  +  TAS+C++QS +LRPRM+Q
Sbjct:    6 KHKRTNAFLLNSASAHDLRCLEVEKEKQDPKSPRGALEACLTRSSISSSSSDDPPPNREASDNADADTDAQCKNHRASSNWGKFFKLWKRRSMKRLSSFPPLSGAAPSISK-SNKTHIDGMVLHDIYDFQSSLHNFSISDIEIATDNFSPENIIGRGGYAEVYQGILPEGKLIAVKRLTKGTPDEQTAEFLSELGIIAHVDHPNTAKFIGCCIEGGMHLVFRLSPLGSLGSLLHGPSKYKLTWSRRYNVALGTADGLVYLHEGCQRRIIHRDIKADNILLTEDFQPQICDFGLAKWLPKQLTHHNVSKFEGTFGYFAPEYFMHGIVDEKTDVFAFGVLLLELITGHPALDESQQSLVLWAKPLLEKKAIRELVDPSLGDEYNREELIRLTSTASLCIDQSSLLRPRMSQ 413          

Query: 1283 QVVTLLRGEDSILST-KASKRRPFQRTYSEEILDAQEYNSTKYLRDLNR 1426
            QVV LL G + ++ T + +K +  QRTYSEE+LD+ EYNSTKYL DL+R
Sbjct:  413 QVVELLLGHEGVVMTPREAKIKMMQRTYSEELLDSVEYNSTKYLGDLDR 461          

Query:  142 SASAQDLRDMDLEKEKEDEGSPRGVLEACVR-------GFESKQPP-----------ELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHPIG--VPKIPKWKSKSTR---ENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            SASA DLR +++EKEK+D  SPRG LEAC+           S+ PP           + +  C N RA S+WG                F P+    P I K ++KS     +  ++ ++++ +SSL  FS+SD+  AT+NF+ EN+IGRGG+AEVY+G L +G+LIAV            A FLSELGIIAHVDHPNTAK IGC ++G MHLVF LS LGSLGS+LHG  K KL W +RYKVALG ADGL+YLHE+CQRRIIHRDIKA+NILLTEDF+PQICDFGLAKWLP+QLTHHNVS FEGTFGYFAPEY+MHGIVDEKTDV++FGVLLLE+ITG  ALD  ++S+V+WAKPLL+   +++LVDPSLGD Y++ ++  +  TAS+C++ S ILRP+M+Q
Sbjct:    3 SASAHDLRCLEVEKEKQDPKSPRGALEACLTQCSISSASSSSEDPPPNREASDNADADADVRCKNPRASSNWGKFFKLWKRRSMKRLSSFPPLSGAAPSISK-RNKSAEPHLDGLILHDIYDFQSSLHNFSISDIEIATDNFNPENIIGRGGYAEVYQGILPEGKLIAVKRLTKGTPDEQTAEFLSELGIIAHVDHPNTAKFIGCCIEGGMHLVFRLSPLGSLGSLLHGPSKDKLTWKRRYKVALGTADGLMYLHESCQRRIIHRDIKADNILLTEDFQPQICDFGLAKWLPKQLTHHNVSKFEGTFGYFAPEYFMHGIVDEKTDVFAFGVLLLELITGHPALDESQQSLVLWAKPLLEKKAIRELVDPSLGDEYNREELIRLTSTASLCIDPSSILRPKMSQ 404          

Query: 1283 QVVTLLRGEDS-ILSTKASKRRPFQRTYSEEILDAQEYNSTKYLRDLNR 1426
            QVV LL GE+  +++ + +K++  QRTYSEE+LD+ EYNSTKYL DL+R
Sbjct:  404 QVVELLLGEEGGVMTPREAKKKMMQRTYSEELLDSVEYNSTKYLGDLDR 452          

Query:   43 WNHKRSFASKSKEVPIVDALNLKPNTLGSLLAWSASAQDLRDMDLEKEKEDEGSPRGVLEACVRGFESKQPPELETSC------SNSRARSHWGXXXXXXXXXXXXXXXXFHPIGVPKIPKWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQASCNTAK-----RGRQY-PIYKSKQKKAFPKNIFRRDI 1377
            W   ++     ++ P  +A++ +    GS    S SAQDLR +D++K K DE +P+G+LE C   F     PE++TSC        SRARSHW                   P+ + K  + KS+S REN +  N  N  SS   FSL +L  AT NF +ENLIG+GG+AEVYKGRL+DGQ IA+              FL ELGIIAHV+HPNTAKLIG GV G +HLV +LS LGSLGS+LH + K KL+WS RYK+ALG ADGL YLHE+CQRRIIHRDIKA+NILLTEDFEPQICDFGLAKWLP+Q TH NV+ FEGTFGYFAPEY+MHGIVDEKTD++SFGVLLLE+ITGRRA+DHMK+S+V+WAKPLL  N++ +LVDP+L D YD+ +M  ++LTAS+C+EQSP+LRPRMNQAS N  K     RG +Y P    + +   PK  +  +I
Sbjct:   13 WKMAKNVRKLLEKTPKDEAVSARDKISGSRFPSSVSAQDLRLLDMKKGK-DEHTPKGILEFCAESFV----PEMQTSCLGSSESKRSRARSHWRSFLNRFTKNSVIRFPSLTPV-MSKRSRGKSQSARENVLAVNTFN--SSWKNFSLVELQNATKNFHHENLIGKGGYAEVYKGRLKDGQFIAIKRLTQGTPEERVMSFLHELGIIAHVNHPNTAKLIGYGVQGGLHLVLQLSPLGSLGSLLHVT-KSKLEWSSRYKIALGTADGLRYLHEHCQRRIIHRDIKADNILLTEDFEPQICDFGLAKWLPKQWTHFNVTKFEGTFGYFAPEYFMHGIVDEKTDIFSFGVLLLELITGRRAVDHMKQSLVVWAKPLLYKNSVAELVDPAL-DEYDEEEMDRMLLTASLCIEQSPVLRPRMNQASTNFRKVVVLLRGDEYNPDGAQESQNHMPKRTYSNEI 459          

Query:   25 QLRYCLWNHKRSFASKSKEVPIVDAL-NLKPNTLGSLLAWSASAQDLRDMDLEKEKEDEGSPRGVLEACVRGFESKQPPELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHPIGVPKIPKWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLH-----------------------------------GSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQASCNTAKR 1305
            Q  YC+W+ K S A + K++ I +A  N K          SASA+D                      C  G +  +  EL TSC N RAR  W                   P  VP IP        ++  +SN+ N +SSLV F+LS+L  AT+NFS ENLIGRGGFAEVYKGRL DGQLIAV            + FLSELGIIAH++HPNTA+LIGCGV+GEMHLVF+LS LG+L S+LH                                    S+K KLDW++RY++ +GIADGLLYLHENCQRRIIHRDIKAEN+LLTE+FEPQICDFGLAKWLPEQ +HHNVS  EGTFGYFAPEY MHGIVDEKTDVYSFGVLLLEIITGRRALDH+ +S+V+ AKPLLDANN+KDLVDPSLGD+YDQ QM  VVLTAS+CVE SPILRPRM+QAS NT KR
Sbjct:    6 QKDYCIWDPKTSPACRLKKISIEEAFFNAKHK--------SASAKD----------------------CFSGLDGNKQSELPTSCKNLRARFQWDKALKLLKKRSINNTSSCPPFCVP-IPN------TDDPTLSNLDNFKSSLVNFTLSELKNATHNFSKENLIGRGGFAEVYKGRLLDGQLIAVKRLNKGTSDERTSNFLSELGIIAHLNHPNTARLIGCGVEGEMHLVFQLSPLGNLDSLLHVNGKGGKCLNENRGGVSGIQTKLEGGLYRQIAVLERSNKNKLDWTRRYRIIVGIADGLLYLHENCQRRIIHRDIKAENVLLTENFEPQICDFGLAKWLPEQCSHHNVSKSEGTFGYFAPEYLMHGIVDEKTDVYSFGVLLLEIITGRRALDHLHQSLVLSAKPLLDANNIKDLVDPSLGDDYDQEQMDRVVLTASLCVEISPILRPRMSQASFNTTKR 431          

Query:  109 KPNTLGSLLAWSASAQDLRDMDLEKEKEDEGSPRGVLEACVR----------------GFESKQPPELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHPIGVPKIPKWKSKSTRENFVMSNVHNL---RSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            K     +LL  S S  DLR  ++EKEK+D  SPRG LEAC+                   E+ +  + E    N RA S+WG                F P+        ++K+   +    NVH++   +SSL +FS++DL  AT+NFS EN+IGRGG+AEVY+G L +G+LIAV            A FLSELGIIAHVDHPNTAK IGC +DG MHLVF LS LGSLGS+LHG  K KL W++RYKVALG ADGL+YLHE CQRRIIHRDIKA+NILLTEDF+PQICDFGLAKWLP+QLTHHNVS FEGTFGYFAPEY+MHGIVDEKTDV++FGVLLLE+ITG  ALD  ++S+V+WAKPLL+   +  LVD SLGD Y+  ++  +  TAS+C+EQS +LRPRM+Q
Sbjct:   40 KHKRTNALLTNSDSVHDLRCQEVEKEKQDTNSPRGALEACLTRCSISSTSSSLDDPPSNREAVENADAEARIKNHRASSNWGKFFKHWKRKSMKRLSSFPPLA-----HRRNKNADTHVDGLNVHDIYDFQSSLHSFSITDLEIATDNFSPENIIGRGGYAEVYQGILPEGKLIAVKRLIKGTPDEKTAEFLSELGIIAHVDHPNTAKFIGCCIDGGMHLVFWLSPLGSLGSLLHGPSKDKLTWNRRYKVALGTADGLMYLHEGCQRRIIHRDIKADNILLTEDFQPQICDFGLAKWLPKQLTHHNVSKFEGTFGYFAPEYFMHGIVDEKTDVFAFGVLLLELITGHPALDDSQQSLVLWAKPLLEKKEITQLVDSSLGDEYNVEELSRLTSTASLCIEQSSLLRPRMSQ 444          

Query: 1283 QVVTLLRGEDSI-LSTKASKRRPFQRTYSEEILDAQEYNSTKYLRDLN 1423
            QVV LL G+  + ++ +  KR   QRTYSE++LD+ EYNSTKYL DL+
Sbjct:  444 QVVELLLGQGGVDMTLREDKRNMMQRTYSEDLLDSIEYNSTKYLGDLD 491          

Query:  142 SASAQDLRDMDLEKEKEDEGSPRGVLEACV-------RGFESKQPP-----------ELETSCSNSRARSHWGXXXXXXXXXXXXXXXXFHPI---GVPKIPKWKSKSTREN-FVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQA 1284
            SASA DLR ++++KEK+D  SPRG LEAC+           S  PP           + +  C N RA S+WGKFFKLWK++S+KRLSSF P+     P I + KS     N  V+ ++++ +SSL  FS+SD+  AT+NFS EN+IGRGG+A+VY+G L +G+LIAVK++T GT +E+TA FLSELGIIAHVDHPNTAK IGC ++G MHLVF LS LGSLGS+LHG  K KL WS+RY VALG ADGL+YLHE CQRRIIHRDIKA+NILLTEDF+PQICDFGLAKWLP+QLTHHNVS FEGTFGYFAPEY+MHGIVDEKTDV++FGVLLLE+ITG  ALD  ++S+V+WAKPLL+   +K+LVDPSLGD Y++ ++  +  TAS+C++QS +LRPRM+Q 
Sbjct:    3 SASAHDLRLLEVDKEKQDPKSPRGALEACLTRCSISSASSSSDDPPPNREAIDNADADTDVQCKNHRASSNWGKFFKLWKRRSMKRLSSFPPLSGAAPPIIKQNKSADPNMNGMVLHDIYDFQSSLQNFSISDIEIATDNFSPENIIGRGGYADVYQGILPEGKLIAVKRLTKGTPDEQTAEFLSELGIIAHVDHPNTAKFIGCCIEGGMHLVFRLSPLGSLGSLLHGPSKYKLTWSRRYNVALGTADGLVYLHEGCQRRIIHRDIKADNILLTEDFQPQICDFGLAKWLPKQLTHHNVSKFEGTFGYFAPEYFMHGIVDEKTDVFAFGVLLLELITGHPALDESQQSLVLWAKPLLERKAIKELVDPSLGDEYNREELIRLTSTASLCIDQSSLLRPRMSQV 405          

Query: 1277 IRQVVTLLRG-EDSILSTKASKRRPFQRTYSEEILDAQEYNSTKYLRDLNR 1426
            + QVV LL G ED +++ + +K +  QRTYSEE+LD+ EYNSTKYL DL+R
Sbjct:  402 MSQVVELLLGHEDVVMTPREAKIKMMQRTYSEELLDSVEYNSTKYLGDLDR 452          

Query:  373 PKIPKWKSKSTRENFVMSNVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVX--XXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHM-KKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            PK+   +S  T E F M+     + S   F+  +L  AT+ F+ EN+IG+GG AEVYKG L +G+ +A+K         EE+ + FLSELGIIAHV+HPN A+L G   D  +H V E +  GSL S+L GS++C L+W  RYKVALGIADGL YLH  C RRIIHRDIKA NILL  D+E QI DFGLAKWLPE   HH V   EGTFGY APEY+MHGIVDEK DV++FGVLLLEIIT RRA+D   ++S+V WAKP L+ N+M+D+VDP LG+ ++  +M  V+LTASMCV     +RP M +
Sbjct:  117 PKLTPSESAFTCEAFFMA-----KPSWRNFTYEELAVATDYFNPENMIGKGGHAEVYKGVLINGETVAIKKLMSHAKEEEERVSDFLSELGIIAHVNHPNAARLRGFSSDRGLHFVLEYAPYGSLASMLFGSEEC-LEWKIRYKVALGIADGLSYLHNACPRRIIHRDIKASNILLNHDYEAQISDFGLAKWLPENWPHHVVFPIEGTFGYLAPEYFMHGIVDEKIDVFAFGVLLLEIITSRRAVDTASRQSIVAWAKPFLEKNSMEDIVDPRLGNMFNPTEMQRVMLTASMCVHHIAAMRPDMTR 416          

Query:  460 FSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXX-XXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKSVVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQA 1284
            F+ +++ KATN+F   N++G GG++EVY+G L DG+ IAVK++   +    K   FL+ELGII+HV HPNTA L+GC V+  ++LVF  S  G+L S LH ++   LDW  RYK+A+G+A GL YLH+ C  RIIHRDIK+ N+LL  D+EPQI DFGLAKWLP + THH V   EGTFGY APE  M G +DEKTD+Y+FG+LLLEIITGRR ++  +K +++WAKP ++  N  +LVDP L D YD +QM  +VLTAS CV+QSPILRP M Q 
Sbjct:  255 FTYNEISKATNDFHQGNIVGIGGYSEVYRGDLWDGRRIAVKRLAKESGDMNKEKEFLTELGIISHVSHPNTALLLGCCVEKGLYLVFRFSENGTLYSALHENENGSLDWPVRYKIAVGVARGLHYLHKRCNHRIIHRDIKSSNVLLGPDYEPQITDFGLAKWLPNKWTHHAVIPVEGTFGYLAPESLMQGTIDEKTDIYAFGILLLEIITGRRPVNPTQKHILLWAKPAMETGNTSELVDPKLQDKYDDQQMNKLVLTASHCVQQSPILRPTMTQV 530          

Query:  457 TFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIG-CGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVST-FEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALD----HMKKSVVIWAKPLLDA----NNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQAS 1287
            TF+  +L +ATN FS  NL+G+GGF  V+KG L++G+ +AVK++  G+++ +   F +E+GII+ V H +   L+G C  D +  LV+E     +L   LHG  +  ++WS R K+A+G A GL YLHENC  +IIHRDIKA NIL+   FE ++ DFGLAK   +  TH  VST   GTFGY APEY   G + EK+DV+SFGV+LLE+ITGRR +D    H   S+V WA+PLL+      N + +VD  L + YD+ +M  +V  A+ CV  +   RPRM+Q +
Sbjct:  341 TFNYEELSRATNGFSEANLLGQGGFGYVFKGMLRNGKEVAVKQLKEGSSQGERE-FQAEVGIISRVHHRHLVALVGYCIADAQRLLVYEFVPNNTLEFHLHGKGRPTMEWSSRLKIAVGSAKGLSYLHENCNPKIIHRDIKASNILIDFKFEAKVADFGLAKIASDTNTH--VSTRVMGTFGYLAPEYASSGKLTEKSDVFSFGVVLLELITGRRPIDVNNVHADNSLVDWARPLLNQVSELGNFEVVVDKKLNNEYDKEEMARMVACAAACVRSTAPRRPRMDQVA 624          

Query:  457 TFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIG-CGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVST-FEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALD----HMKKSVVIWAKPL----LDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            TF+  +L +ATN FS  NL+G GGF  VYKG L +G  +AVK++  G+ + +   F +E+ II+ + H N   L+G C    +  LV+E     +L   LHG  +  ++WS R K+A+  + GL YLHENC  +IIHRDIKA NIL+   FE ++ DFGLAK   +  TH  VST   GTFGY APEY   G + EK+DVYSFGV+LLE+ITGRR +D    +   S+V WA+PL    L+ +N + L D  L + YD+ +M  +V  A+ CV  +   RPRM+Q
Sbjct:  170 TFTYGELARATNKFSEANLLGEGGFGFVYKGILNNGNEVAVKQLKVGSAQGEKE-FQAEVNIISQIHHRNLVSLVGYCIAGAQRLLVYEFVPNNTLEFHLHGKGRPTMEWSLRLKIAVSSSKGLSYLHENCNPKIIHRDIKAANILIDFKFEAKVADFGLAKIALDTNTH--VSTRVMGTFGYLAPEYAASGKLTEKSDVYSFGVVLLELITGRRPVDANNVYADDSLVDWARPLLVQALEESNFEGLADIKLNNEYDREEMARMVACAAACVRYTARRRPRMDQ 451          

Query:  457 TFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIG-CGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVST-FEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALD----HMKKSVVIWAKPLL----DANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            TF+  +L +ATN FS  NL+G+GGF  V+KG L  G+ +AVK++  G+ + +   F +E+ II+ V H +   LIG C    +  LV+E     +L   LHG  +  ++WS R K+ALG A GL YLHE+C  +IIHRDIKA NIL+   FE ++ DFGLAK   +  TH  VST   GTFGY APEY   G + EK+DV+SFGV+LLE+ITGRR +D    ++  S+V WA+PLL    +  + + L D  +G+ YD+ +M  +V  A+ CV  S   RPRM+Q
Sbjct:  267 TFTYEELSRATNGFSEANLLGQGGFGYVHKGILPSGKEVAVKQLKAGSGQGERE-FQAEVEIISRVHHRHLVSLIGYCMAGVQRLLVYEFVPNNNLEFHLHGKGRPTMEWSTRLKIALGSAKGLSYLHEDCNPKIIHRDIKASNILIDFKFEAKVADFGLAKIASDTNTH--VSTRVMGTFGYLAPEYAASGKLTEKSDVFSFGVVLLELITGRRPVDANNVYVDDSLVDWARPLLNRASEEGDFEGLADSKMGNEYDREEMARMVACAAACVRHSARRRPRMSQ 548          

Query:  388 WKSKSTRENFVMS-NVHNLRSSLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDG-EMHLVFELSTLGSLGSVLHG--SDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKS----VVIWAKPLLDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQA 1284
            WK    R    M  +  +L   + +FSL  +  ATNNF + N IG GGF  VYKG+L DG +IAVK+++TG+ +     FL+E+G+I+ + HPN  KL GC V+G ++ LV+E     SL   L G    + +LDW  R K+ +G+A GL YLHE  + +I+HRDIKA N+LL +   P+I DFGLAK L E+ + H  +   GTFGY APEY M G + +K DVYSFG++ LEI+ GR       K+    ++ W + L + NN+ +LVDP LG  Y++ +   ++  A MC    P  RP M++ 
Sbjct:  587 WKKGYLRSKSQMEKDFKSLELMIASFSLRQIKIATNNFDSANRIGEGGFGPVYKGKLFDGTIIAVKQLSTGSKQGNRE-FLNEIGMISALHHPNLVKLYGCCVEGGQLLLVYEFVENNSLARALFGPQETQLRLDWPTRRKICIGVARGLAYLHEESRLKIVHRDIKATNVLLDKQLNPKISDFGLAK-LDEEDSTHISTRIAGTFGYMAPEYAMRGHLTDKADVYSFGIVALEIVHGRSNKIERSKNNTFYLIDWVEVLREKNNLLELVDPRLGSEYNREEAMTMIQIAIMCTSSEPCERPSMSEV 891          

Query:  448 SLVTFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMH-LVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMKKS----VVIWAKPLL-DANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            S+ TF+LS+L KAT+ FS + ++G GGF  VY+G ++DG  +AVK +T          F++E+ +++ + H N  KLIG  ++G    L++EL   GS+ S LH   +  LDW  R K+ALG A GL YLHE+   R+IHRD KA N+LL +DF P++ DFGLA+   E  + H  +   GTFGY APEY M G +  K+DVYS+GV+LLE++TGRR +D  + S    +V WA+PLL +   ++ LVDP+L   Y+   M  V   ASMCV Q    RP M +
Sbjct:  333 SVKTFTLSELEKATDRFSAKRVLGEGGFGRVYQGSMEDGTEVAVKLLTRDNQNRDRE-FIAEVEMLSRLHHRNLVKLIGICIEGRTRCLIYELVHNGSVESHLH---EGTLDWDARLKIALGAARGLAYLHEDSNPRVIHRDFKASNVLLEDDFTPKVSDFGLAREATEG-SQHISTRVMGTFGYVAPEYAMTGHLLVKSDVYSYGVVLLELLTGRRPVDMSQPSGEENLVTWARPLLANREGLEQLVDPALAGTYNFDDMAKVAAIASMCVHQEVSHRPFMGE 611          

Query:  460 FSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIG-CGVDGEMHLVFELSTLGSLGSVLHGSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVST-FEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMK-----KSVVIWAKPL----LDANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRPRMNQ 1281
            F+  DL KAT+NFSN NL+G+GGF  V++G L DG L+A+K++ +G+ + +   F +E+  I+ V H +   L+G C    +  LV+E     +L   LH  ++  ++WSKR K+ALG A GL YLHE+C  + IHRD+KA NIL+ + +E ++ DFGLA+   +  TH  VST   GTFGY APEY   G + EK+DV+S GV+LLE+ITGRR +D  +      S+V WAKPL    L+  N   LVDP L +++D  +M  +V  A+  V  S   RP+M+Q
Sbjct:  131 FTYEDLSKATSNFSNTNLLGQGGFGYVHRGVLVDGTLVAIKQLKSGSGQGERE-FQAEIQTISRVHHRHLVSLLGYCITGAQRLLVYEFVPNKTLEFHLHEKERPVMEWSKRMKIALGAAKGLAYLHEDCNPKTIHRDVKAANILIDDSYEAKLADFGLARSSLDTDTH--VSTRIMGTFGYLAPEYASSGKLTEKSDVFSIGVVLLELITGRRPVDKSQPFADDDSIVDWAKPLMIQALNDGNFDGLVDPRLENDFDINEMTRMVACAAASVRHSAKRRPKMSQ 412          

Query:  457 TFSLSDLIKATNNFSNENLIGRGGFAEVYKGRLQDGQLIAVXXXXXXXXXXXXAGFLSELGIIAHVDHPNTAKLIGCGVDGEMHL-VFELSTLGSLGSVLH--GSDKCKLDWSKRYKVALGIADGLLYLHENCQRRIIHRDIKAENILLTEDFEPQICDFGLAKWLPEQLTHHNVSTFEGTFGYFAPEYYMHGIVDEKTDVYSFGVLLLEIITGRRALDHMK----KSVVIWAKPLL-DANNMKDLVDPSLGDNYDQRQMGCVVLTASMCVEQSPILRP 1269
            TF+ S+L  AT NF  E LIG GGF  VYKG L      A  K       +    FL E+ +++ + HPN   LIG   DG+  L V+E   LGSL   LH     K  LDW+ R K+A G A GL YLH+     +I+RD+K  NILL +D+ P++ DFGLAK  P     H  +   GT+GY APEY M G +  K+DVYSFGV+LLEIITGR+A+D  +    +++V WA+PL  D      + DP L   Y  R +   +  A+MCV++ P LRP
Sbjct:   60 TFTFSELATATRNFRKECLIGEGGFGRVYKGYLASTSQTAAIKQLDHNGLQGNREFLVEVLMLSLLHHPNLVNLIGYCADGDQRLLVYEYMPLGSLEDHLHDISPGKQPLDWNTRMKIAAGAAKGLEYLHDKTMPPVIYRDLKCSNILLDDDYFPKLSDFGLAKLGPVGDKSHVSTRVMGTYGYCAPEYAMTGQLTLKSDVYSFGVVLLEIITGRKAIDSSRSTGEQNLVAWARPLFKDRRKFSQMADPMLQGQYPPRGLYQALAVAAMCVQEQPNLRP 338