Ca_01644, Ca_01644_v1.0_kabuli (mRNA) Cicer arietinum

Query:   16 PSGAPQPQNITMVAVDKDKNSAYAFRWAINHLDNP-----VIVAVHVKHKNLPNLGTNVYPPDE--EDVALIFNN------------LRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASAR-------------------------------SAVRSMGNGNQSIPSKLPVQVGQHAEFETGIRSV-LPRSSVTNE--------GSESRSFDSITATKGQTRER--PR--------SAGSNLSMDKIDIPGGRGRHWASMD-ERDMAALGPIDLDVPDSLGTPSASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVP-SSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVE-KDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLR 2031
            P   P P    +VA+     S Y   WAI            ++ +H    ++P    N  P  E  +DV   +                 +  R+ V ++  VI+  +V   + +   R+SI  IVIG S+++       F    DI + I    P++C+VY++SK K++  R                               S V S  + +QS P  LPV+  QH     G  SV +  SSV ++          E+R   SI  +   T  R  PR         A S+ S ++     G    W+ M  +   +       ++ D+L   S +    +L  E+++LR EL+   +MY+ A  +   A  +  ++               + +                                                 +++   L     +Y+ +  EEI  AT  FS   K+G G YG VYK +L HT   +K+L    +Q  KQFQQE+E+LS IRHP++VLLLGACPE G LVYE+M+NGSLEDRLF+ NNS PL W +RF+I+ E+A AL+FLH++KP+PI+HRDLKP+NILLD N+VSK+ DVGL+ +V    +    T Y  TS  GT CYIDPEYQ+TG +++KSDIYS G++LLQ++TAKP + L H V+ A++  D  ++ILD    +WP+E     A LAL C EL  KDRP+L   +LP L  L+
Sbjct:   12 PPPPPPPSRTVVVALSGSSKSKYVVTWAIEKFATEGNVGFKLLHIHPMITSVPTPMGNAIPISEVRDDVVTAYRQEILWQSEEMLKPYTKLFVRRKVAVEVLVIESDNVAAAIAEEVTRDSIDRIVIGGSSRSF------FSRKADICSVISALMPNFCTVYVVSKGKLSCVRPSDSDGNATIREDGSERTNSSSGSSGPTSDSSDVMSSAHDSQSRPLSLPVRRMQHFPAIAGQASVPMETSSVGSDETRCMSLDAEEARDVSSINRSSTDTTSRWTPRRRDYEERKEAMSSSSSNREYGNFGTRFSWSGMGVDTTHSRASQQASNMSDALSEQSYTDNQVNLNFEVEKLRAELRHVQEMYAVAQTETFDASRKLGELNQRRLEEAIKLEELKLKEYEARELAEKEKQNFEKARRDAESMRERAEREIAQRREAERKSARDTKEKEKLEGTLGSPQLQYQHFAWEEIMAATSSFSEELKIGMGAYGAVYKCNLHHTTAVVKVLQSAENQLSKQFQQELEILSKIRHPHLVLLLGACPEQGALVYEYMENGSLEDRLFQVNNSPPLPWFERFRIAWEVAAALVFLHKSKPKPIIHRDLKPANILLDHNFVSKVGDVGLSTMVQVDPLSTKFTIYKQTSPVGTLCYIDPEYQRTGRISSKSDIYSFGMILLQLLTAKPAIALTHFVESAMDSNDEFLKILDQKAGNWPIEETRELAALALCCTELRGKDRPDLKDQILPALENLK 749          

Query:   28 PQPQNITMVAVDKDKNSAYAFRWA--------------------INHLDNPVIVAVHVKHKNLPNLGTNVYPPDEEDVALIFNNL----RAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASAR-------SAVRSMGNGNQSIPSKLPVQVGQHAEFETGIRS----VLPRSSVTNEGSESRSFDSITATKGQTRERPRSAGSNLSMDKIDIPGGRGRH------------------WASM-----DERDMAALGP------IDLD----VPDSLGTPS--ASHTSK-------------DLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKD-RIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLR 2031
            P P     VA++  K S Y   WA                    ++++  P+ +AV V       L  +V    ++++    N +    + M +R+ V ++  ++D  +    + +      +  +VIG S +        F    D+ + I  + P +C+VY+ISK K+AS R        ++R   + + S  +  P    ++ +F + +      V P S        S +   +  +   T +   S G  + +    I G + +                   W S      D R+M +         +++D    VP++    S  ASH S              +L  E+++LR ELK   +MY+ A  + + A  +  ++                 +                                                 D++  +L     +Y+ YT EEI  AT  F+ + K+G G YG VYK +L HT  A+K+L+   +Q  KQF QE+E+LS IRHP++VLLLGACPE GCLVYE+MDNGSL+DRL   N++ P+ W +RF+I+ E+A+AL+FLH++KP PI+HRDLKP NILLD N+VSK+ DVGL+ +V    V + T +  TS  GT CYIDPEYQ+TGI++ KSD+YSLGV++LQ+ITAKP + + H V+ A+  D   + ILD     WP+      A L L C E+ ++DRP+L   ++P L RLR
Sbjct:   18 PPPSPSVAVAINGKKKSKYVVFWALEKFIPEGFTDFKLLYVRPPVSYIPTPMGIAVAVSE-----LREDVVSAYKQELDWSANEMLRPYKKMFERRKVQVEVLLLDSLEPAAAIAEEIAGTGVTKLVIGMSLRGF------FSRKIDMSSLIATAVPRFCTVYVISKGKLASVRPSESDASGSIRFERSSSTSGSTDSPRLPPEYQDFLSAVSEAQSRVSPFSPALKHSMGSNAVAQMDTSSSGTDQEEVSTGRGMEIVHSGIEGKKNKDESFSASFPMGTEAYNSMSWTSKWRDHEDRREMRSSSSSNNHDLVNMDWGAVVPENYSWVSHTASHMSDGLLSVHSITDNQVNLNFEIEKLRAELKHVQEMYAMAQTETVGASKKLTELNQRRFEESEKLVELKEKEEVAKDTASKEKQRYEEAMKEAEKVKELMMKEALHRREAEFKAERDAREKDKLQASLVSPGVQYQHYTWEEIAAATSDFAENLKIGIGAYGSVYKCNLHHTTGAVKVLHAGETQLSKQFDQELEILSKIRHPHLVLLLGACPERGCLVYEYMDNGSLDDRLMLVNDTPPIPWFERFRIALEVASALVFLHKSKPRPIIHRDLKPGNILLDHNFVSKLGDVGLSTMVNQDDVSSRTIFKQTSPVGTLCYIDPEYQRTGIISPKSDVYSLGVVILQLITAKPAIAITHMVEEAIGDDAEFMAILDKKAGSWPISDTRELAALGLCCTEMRRRDRPDLKDQIIPALERLR 758          

Query: 1147 RVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRL 2028
            +V+  L   D+RYRKYT+EEI  ATE FSP K +GEGGYG VY+  LD T  A+K++  +  + +++F +EVEVLS +RHP++VLLLGACPE+GCLVYE+++NGSLE+ +F + N  PL W  RF++  E+A  L FLH +KPEPIVHRDLKP NILL+RNYVSKI+DVGLA+LV     DNVT Y  +  AGT  YIDPEY +TG +  KSD+Y+ G+++LQ++TA+ P G+   V+ AV+K  + E+LD +VTDWP+      A++ L C E   +DRP+L + V+P L RL
Sbjct:  415 KVIDQLLGTDHRYRKYTIEEIVTATEGFSPEKVIGEGGYGKVYQCSLDSTPAAVKVVRLDTPEKKQEFLKEVEVLSQLRHPHVVLLLGACPENGCLVYEYLENGSLEEYIFHRKNKPPLPWFIRFRVIFEVACGLAFLHSSKPEPIVHRDLKPGNILLNRNYVSKIADVGLAKLVTDVAPDNVTMYRNSVLAGTLHYIDPEYHRTGTIRPKSDLYAFGIIILQLLTARNPSGIVPAVENAVKKGTLTEMLDKSVTDWPLAETEELARIGLKCAEFRCRDRPDLKSEVIPVLKRL 708          

Query: 1180 RYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSS--VVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEK---DRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKNNSHSPRPPMP 2106
            +Y+++T EEI  AT  FS   K+G G YG VYK +L HT  A+K+L+   S   KQF QE+E+LS IRHP++VLLLGACP+HG LVYE+M+NGSLEDRLF+ N+S+P+ W  R +I+ E+A+AL+FLH++KP PI+HRDLKP+NILL+ N+VSK+ DVGL+ ++ ++  +    T Y  TS  GT CYIDPEYQ+TG ++ KSD+Y+ G+++LQ++T +  M L + V+ A+E    D +++ILD    +WP+E     A LAL C EL  KDRP+L   +LP L  L+ +         D   NS S  P  P
Sbjct:  444 QYQEFTWEEIINATSSFSEDLKIGMGAYGDVYKCNLHHTIAAVKVLHSAESSLSKQFDQELEILSKIRHPHLVLLLGACPDHGALVYEYMENGSLEDRLFQVNDSQPIPWFVRLRIAWEVASALVFLHKSKPTPIIHRDLKPANILLNHNFVSKVGDVGLSTMIQAADPLSTKFTMYKQTSPVGTLCYIDPEYQRTGRISPKSDVYAFGMIILQLLTGQQAMALTYTVETAMENNNDDELIQILDEKAGNWPIEETRQLAALALQCTELRSKDRPDLEDQILPVLESLKKV--------ADKARNSLSAAPSQP 749          

Query: 1180 RYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNS------RPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAV--EKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKNNSHSPRP 2097
            +Y K+  EEI  AT  FS   K+G GGYG VY+ +L HT VA+K+L+ + S   KQF QE+E+LS IRHP+++LLLGACPE G LVYE+M NGSLE+RL ++  +       PL W +RF+I+ EIA+AL FLH  +P PIVHRDLKP+NILLDRN VSKI DVGL+++V        T +  T   GTF YIDPEYQ+TG++T +SDIY+ G++LLQ++TA+  MGLAH +++A+  +  +  EILD    DWPV+ A     + L C E+ K+DRP+L   +LP L RL+++      +F D   + H   P
Sbjct:  413 QYMKFEWEEIVEATSSFSDELKIGVGGYGSVYRCNLHHTTVAVKVLHSDKSSLTKQFHQELEILSKIRHPHLLLLLGACPERGSLVYEYMHNGSLEERLMKRRPNVDTPQPPPLRWFERFRIAWEIASALYFLHTNEPRPIVHRDLKPANILLDRNNVSKIGDVGLSKMVNLDPSHASTVFNETGPVGTFFYIDPEYQRTGVVTPESDIYAFGIILLQLVTARSAMGLAHSIEKALRDQTGKFTEILDKTAGDWPVKEAKEMVMIGLRCAEMRKRDRPDLGKEILPVLERLKEVASIARNMFADNLIDHHHNAP 726          

Query: 1156 TALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLR 2031
            T+  Q    +  ++  EIE AT  F  + K+GEGGYG +Y G L HT VAIK+LNP +SQG  ++QQEV+VLS +RHPN++ L+GACPE   LVYE++  GSLEDRL  K+NS PL+WQ R +I+ EI  AL+FLH  K   +VH DLKP+NILLD N VSK+SD G   L+      N ++   T   GT  Y+DPE   +G LT KSD+YS G++LL+++T +P + +++ VK A++   + ++LDP   DWP   A   A+LAL C E   ++RP+L T V   L  +R
Sbjct:  457 TSTLQLPQYFTDFSFSEIEEATNHFDSTLKIGEGGYGSIYVGLLRHTQVAIKMLNPNSSQGPVEYQQEVDVLSKMRHPNIITLIGACPEGWSLVYEYLPGGSLEDRLTCKDNSPPLSWQNRVRIATEICAALVFLHSNKAHSLVHGDLKPANILLDSNLVSKLSDFGTCSLLH----PNGSKSVRTDVTGTVAYLDPEASSSGELTPKSDVYSFGIILLRLLTGRPALRISNEVKYALDNGTLNDLLDPLAGDWPFVQAEQLARLALRCCETVSENRPDLGTEVWRVLEPMR 744          

Query: 1192 YTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKN--NSHSPRPP 2100
            Y+  EI  AT +F PS KLGEG YG VYKG+L H  VA+K+L    S    +F++ VE+LS +RHPN+V L+GACPE   L+Y+++ NGSLED    +NN   L+W+ R +I++EI +ALLFLH   P  I+H +LKPS ILLD N V+KI+D G+++L+P   +D               ++DP Y  +  +T +SDIY+ G++LLQ++T +P  G+   VK A+E D I  +LD +  DWPV      A +A+ C + +  +RP+LA VVL  ++R++       +  ++T +  N + PR P
Sbjct:  448 YSFMEINEATNEFDPSWKLGEGKYGSVYKGNLQHLQVAVKMLPSYGSLNHFEFERRVEILSRVRHPNLVTLMGACPESRSLIYQYIPNGSLEDCFSSENNVPALSWESRIRIASEICSALLFLHSNIP-CIIHGNLKPSKILLDSNLVTKINDYGISQLIPIDGLDKSDP-----------HVDPHYFVSREMTLESDIYAFGIILLQLLTRRPVSGILRDVKCALENDNISAVLDNSAGDWPVARGKKLANVAIRCCKKNPMNRPDLA-VVLRFIDRMK----APEVPSSETSSYANQNVPRRP 735          

Query: 1192 YTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVV 2007
            ++ +++E ATE F  ++++G+  YG  YKG + +  V IKL     S  +K FQQEV +L   RHPN++  +G C E   LVYE++ NG+LEDR+   NNS PL+W  R QI  EI  ALLFLH  K   +VH DL+P NIL+D NY SKI + G++ L            +  +      Y+DPE+  TG LTT SD+YSLGV++L+++T  PP+ L+  V  A+  D +  ++D +  DWP   A   A + L C  +++K RP+L   V
Sbjct:  147 FSRKDMEQATEHFKNAREVGDTEYGHTYKGMIHNMKVLIKL-----SSSQKLFQQEVSILRQWRHPNIITFIGVCSEVSALVYEWLPNGNLEDRIICTNNSAPLSWYNRTQIIGEICCALLFLHSNKSTALVHGDLRPCNILIDANYRSKICNFGMSNLFLQ------LGTFPPNLTARLPYMDPEFNTTGELTTLSDVYSLGVIILRLLTGMPPLTLSEKVAEALGSDSLHLLIDKSAGDWPYIEAKQLALIGLSCTGMTRKKRPDLLNEV 407          

Query: 1186 RKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHL-DHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPE--HGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMG-------LAHHVKRAVEKDRIVEILDPAVT-DWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDN 2052
            R YT EE+ V T  F   + LGEGG+G VY G++ D+  VA+K+L+  ++QG KQF+ EV++L  + H N+V L+G C E  H  L+YE+M NG+L+  L  +N+  PL+W+ R +I+AE A  L +LH     P++HRD+K  NILLD N+ +K+ D GL+R  P     +V+    T+ AG+  Y+DPEY +T  LT KSD++S GV+LL++IT++P +        +   V   +    I  I+DP++  D+   +     +LA+ CV  S   RPN++ V     N L++   T+N
Sbjct:  579 RSYTYEEVAVITNNFE--RPLGEGGFGVVYHGNVNDNEQVAVKVLSESSAQGYKQFKAEVDLLLRVHHINLVTLVGYCDEGQHLVLIYEYMSNGNLKQHLSGENSRSPLSWENRLRIAAETAQGLEYLHIGCKPPMIHRDIKSMNILLDNNFQAKLGDFGLSRSFPVGSETHVS----TNVAGSPGYLDPEYYRTNWLTEKSDVFSFGVVLLEIITSQPVIDQTREKSHIGEWVGFKLTNGDIKNIVDPSMNGDYDSSSLWKALELAMSCVSPSSSGRPNMSQVA----NELQECLLTEN 868          

Query: 1153 LTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHL-DHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGAC--PEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTS-AAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPM---------GLAHHVKRAVEKDRIVEILDPAVTD-WPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLR 2031
            LT    N    + ++ +E+E AT+ F+ ++ LG+GG G VYKG L D   VA+K          ++F  EV VLS I H N+V L+G C   E   LVYE + NG L  RL   ++   +TW  R +IS EIA AL +LH     P+ HRD+K +NILLD  Y +K+SD G +R +      NV Q ++T+  AGTF Y+DPEY QT   T KSD+YS GV+L+++IT + P          GL  H   A++++R+++I+D  + +   +E  L+ AKLA  C+ L  K RPN+  V + EL R+R
Sbjct:  396 LTTRGGNVQSSKIFSSKELEKATDNFNMNRVLGQGGQGTVYKGMLVDGRIVAVKRSKVLDEDKVEEFINEVGVLSQINHRNIVKLMGCCLETEVPILVYEHIPNGDLFKRLHHDSDDYTMTWDVRLRISVEIAGALAYLHSAASTPVYHRDVKTTNILLDEKYRAKVSDFGTSRSI------NVDQTHLTTLVAGTFGYLDPEYFQTSQFTDKSDVYSFGVVLVELITGEKPFSVMRPEENRGLVSHFNEAMKQNRVLDIVDSRIKEGCTLEQVLAVAKLARRCLSLKGKKRPNMREVSV-ELERIR 695          

Query:    1 MSVQQPSGAPQPQNITMVAVDKDKNSAYAFRWAINHLDNPVIVAVHVKHKNLPNL---------------GTNVYPPDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNGNQSIPSK-LPVQVGQHAEFETGIRSVLPRSSVTNEGSESRSFDSITATKGQTRERPRSAGSNLSMDKIDIPGGRGRHWASMDERDMAALGPI------DLDVPDSLGTPSASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKNNSHSPRPPMPT 2109
            MS+Q+PSG PQ QN+TMVAVDK K+SAYAFRWAI  +DNP+I+AVHVK+KNL N                GTNVYPPDE++VA IFNNLRA+C  K VTMKE V+DD DVVKGLLDFANRN +HS+VIGAS KN + SLKKFK   DIP +IIKSAP YCSVYIISKLKI S R AVR +GN  Q IP+K L VQV    EFE+GIRS+ PR+S TNEGSESRSFDSI+  KG  R+RPRSAGSN SMD ID  GGRGRHWASMDER++AALGPI      +L + DS GT   SHTSK+LEAEMKRLR ELKQTMDMYSSACKQAISAKNQAEQI               +SQ                                                 ++VL ALAQNDNRYRKYTM EIEVATE+FSPSKKLGEGGYGPV+KGHL HT VA+KLLNPEA+QGRKQF QEVEVLS IRHPNMVLLLGACPEH CLVYE+M+NG+LEDRLFRKNNS+PL+WQKRF+I+AEIATALLFLHQTKPEPIVHRDLKPSNILLD+NYVSK++DVGLARLVP SV D+VTQYYMTSAAGTFCYIDPEYQQTG+LT KSDIYSLG+MLLQ+ITA+PPMGL+HHVKRA+EKD+  EILD AVTDWPVE ALSFAKLAL C EL KKDRPNLA+VVLPELNRLR LG  DN VFTDTKNNSHS RPPMPT
Sbjct:    1 MSLQEPSGPPQ-QNVTMVAVDKGKSSAYAFRWAIRCIDNPIIIAVHVKNKNLLNRRLQYKTEIVTLLNAEGTNVYPPDEDEVAQIFNNLRALCPSKMVTMKEVVVDDQDVVKGLLDFANRNLVHSLVIGASTKNLMPSLKKFKASQDIPTSIIKSAPGYCSVYIISKLKIVSTRPAVREIGN--QIIPTKQLAVQVSP--EFESGIRSIQPRTSGTNEGSESRSFDSISTVKGPARDRPRSAGSNQSMDNIDPSGGRGRHWASMDEREIAALGPIVDVNRHELYLIDSFGTHPTSHTSKELEAEMKRLRLELKQTMDMYSSACKQAISAKNQAEQIRRWKEEEGRKVVEVRLSQEAALAIAEREKAKAKAALEAAEEAKRKAEQEAQRRKEAEMKARKEAEERNKVLNALAQNDNRYRKYTMMEIEVATERFSPSKKLGEGGYGPVFKGHLHHTPVAVKLLNPEAAQGRKQFNQEVEVLSSIRHPNMVLLLGACPEHCCLVYEYMENGTLEDRLFRKNNSKPLSWQKRFKIAAEIATALLFLHQTKPEPIVHRDLKPSNILLDKNYVSKVADVGLARLVPPSVADSVTQYYMTSAAGTFCYIDPEYQQTGMLTPKSDIYSLGIMLLQIITARPPMGLSHHVKRAIEKDQFSEILDSAVTDWPVEEALSFAKLALNCAELCKKDRPNLASVVLPELNRLRGLGFNDNQVFTDTKNNSHSLRPPMPT 720          

Query:    1 MSVQQPSGAPQPQNITMVAVDKDKNSAYAFRWAINHLDNPVIVAVHVKHKNLPNLGTNVYPPDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYH--DIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNGNQSIPSKLPVQVGQHAEFETG-IRSVLPRSSVTNEGSESRSFDSITATKGQTRERPRSAGSNLSMD-KIDIPGGRGRHWASMDERDMAALGPIDL-------DVPDSLGTPSASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCT--DNIVFTDTKN--NSHSPRPPMP 2106
            MSVQQP  A   QN TMVAVDKDKNS +AFRWA+NHLDNP+I+AVHVKHKN  +  TNV+PPDEEDVA IFN LR MC RKAV MKEAVIDD DVV+GLL++ANRN+IHSIV+GAS KN L SLKKFK Y   DIP A+IKSAPDYCSVYIISKLKI SARSAVRSM  G  + P +LPVQ    +E E G +R   PRS  T EG        +   + Q RERPRSAGS +S+D  ID+     RHW SMDER++A L  +D+       DV DS GT S   +SK+LEAEMKRLR ELKQTMDMYSSACKQAISAKNQAEQI               +SQ                                                 +R L+ALA NDNRYRKYT+ EIE ATEKF P  K+GEGGYGPVYKGHLDHT VAIK+L P+A  G KQFQQE+EVLSCIRHP+MVLLLGACPEHGCLVYE+MDNGSLEDRL+RKNNSRP++W+KRFQI+AEIATALLFLHQ KPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVP+SV D +TQYYMTSAAGTFCYIDPEYQQTGILTTKSD+YSLG+MLLQ+ITAKPPMGLAH VK+A+EK R  EILDP VTDWPVE ALSFAKL L C ELSKKDRPNLATVVLPELNRL +L  T  ++ VF  ++   NS++  PP P
Sbjct:    1 MSVQQPPCAAPLQNTTMVAVDKDKNSVHAFRWAVNHLDNPIIIAVHVKHKNFSHHVTNVFPPDEEDVANIFNTLRGMCTRKAVKMKEAVIDDSDVVRGLLEYANRNAIHSIVVGASTKNPLISLKKFKTYQYQDIPTAMIKSAPDYCSVYIISKLKIVSARSAVRSMSKGFMA-PKQLPVQACPPSEPEGGSVRGQPPRSRSTYEGP-------VEPMRIQARERPRSAGS-MSIDINIDVHT-HPRHW-SMDEREIAGLVTMDVTKQDSIPDVSDSFGT-SGPQSSKELEAEMKRLRLELKQTMDMYSSACKQAISAKNQAEQIRQWKMEEDRKVEVVRLSQEAALALAEREKIRAKAALEAAEEARRRAEQDAQRRKDAEMKARLEAEEKERALSALAHNDNRYRKYTIVEIEAATEKFYPLNKIGEGGYGPVYKGHLDHTPVAIKILRPDAVHGMKQFQQEIEVLSCIRHPHMVLLLGACPEHGCLVYEYMDNGSLEDRLYRKNNSRPISWRKRFQIAAEIATALLFLHQNKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPASVADTMTQYYMTSAAGTFCYIDPEYQQTGILTTKSDVYSLGIMLLQIITAKPPMGLAHIVKKAIEKGRFEEILDPVVTDWPVEEALSFAKLPLKCSELSKKDRPNLATVVLPELNRLSELELTLHNDQVFYSSEGMINSYAACPPTP 705          

Query:  169 TNVYPPDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYH--DIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNGNQSIPSKLPVQVGQHAEFETG-IRSVLPRSSVTNEGSESRSFDSITATKGQTRERPRSAGSNLSMD-KIDIPGGRGRHWASMDERDMAALGPIDL-------DVPDSLGTPSASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCT--DNIVFTDTKN--NSHSPRPPMP 2106
            TNV+PPDEEDVA IFN LR MC RKAV MKEAVIDD DVV+GLL++ANRN+IHSIV+GAS KN L SLKKFK Y   DIP A+IKSAPDYCSVYIISKLKI SARSAVRSM  G  + P +LPVQ    +E E G +R   PRS  T EG        +   + Q RERPRSAGS +S+D  ID+     RHW SMDER++A L  +D+       DV DS GT S   +SK+LEAEMKRLR ELKQTMDMYSSACKQAISAKNQAEQI               +SQ                                                 +R L+ALA NDNRYRKYT+ EIE ATEKF P  K+GEGGYGPVYKGHLDHT VAIK+L P+A  G KQFQQE+EVLSCIRHP+MVLLLGACPEHGCLVYE+MDNGSLEDRL+RKNNSRP++W+KRFQI+AEIATALLFLHQ KPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVP+SV D +TQYYMTSAAGTFCYIDPEYQQTGILTTKSD+YSLG+MLLQ+ITAKPPMGLAH VK+A+EK R  EILDP VTDWPVE ALSFAKL L C ELSKKDRPNLATVVLPELNRL +L  T  ++ VF  ++   NS++  PP P
Sbjct:   31 TNVFPPDEEDVANIFNTLRGMCTRKAVKMKEAVIDDSDVVRGLLEYANRNAIHSIVVGASTKNPLISLKKFKTYQYQDIPTAMIKSAPDYCSVYIISKLKIVSARSAVRSMSKGFMA-PKQLPVQACPPSEPEGGSVRGQPPRSRSTYEGP-------VEPMRIQARERPRSAGS-MSIDINIDVHT-HPRHW-SMDEREIAGLVTMDVTKQDSIPDVSDSFGT-SGPQSSKELEAEMKRLRLELKQTMDMYSSACKQAISAKNQAEQIRQWKMEEDRKVEVVRLSQEAALALAEREKIRAKAALEAAEEARRRAEQDAQRRKDAEMKARLEAEEKERALSALAHNDNRYRKYTIVEIEAATEKFYPLNKIGEGGYGPVYKGHLDHTPVAIKILRPDAVHGMKQFQQEIEVLSCIRHPHMVLLLGACPEHGCLVYEYMDNGSLEDRLYRKNNSRPISWRKRFQIAAEIATALLFLHQNKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPASVADTMTQYYMTSAAGTFCYIDPEYQQTGILTTKSDVYSLGIMLLQIITAKPPMGLAHIVKKAIEKGRFEEILDPVVTDWPVEEALSFAKLPLKCSELSKKDRPNLATVVLPELNRLSELELTLHNDQVFYSSEGMINSYAACPPTP 679          

Query:   40 NITMVAVDKDKNSAYAFRWAINHL--DNPVIVAVHVKHKNLPNLGTNVYPPDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNGNQSIPSKLPVQVG-------QHAEF-ETGIRSVLPRSSVTNEGSESRSFDSITATKGQTRERPRSAGSNLSMDKIDI--PGGRG-----RHWASMDERDMA---ALGPIDLDV--PD-SLGTP---SASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKNNSHSPR 2094
            N   VA+DKDKNS +  RWAI+HL  +NPVI+ VHV+HKN  +   N    D ++V  +F   R  C RK V +KE +++D+DV + LLD+ ++N + SIV+GAS +N  T  +KFK   D+P+++IKS PD+CSVY+ISK KIAS R+A R   N    IP K+P  +         H+++ + GIR    RS+    G                R+R R+  SNLSMD IDI  PGG          ++ ++ D +   ALG ID+    PD SLG+P   +AS  ++D+EAEM+RLR ELKQT+DMYS+AC++A++AK +A ++                ++                                                 +R LTALA ND RYRKYT+EEIE ATEKFS S K+GEGGYGPVYKG LDHTAVAIK+L P+A+QG+KQFQQEVEVLSCIRHP+MVLLLGACPE+GCLVYE+MDNGSLEDRL +++N+ P++W++RF+I+AEI+TALLFLHQ KPEP+VHRDLKP+NILLDRNYVSKISDVGLARLVP SV D+VTQY+MTSAAGTFCYIDPEYQQTG+LTT+SDIYSLG++LLQ+ITAKPPMGLAHHV +A+E+    ++LDP+V DWPVE AL+FAKLAL C EL KKDRPNL TV++PEL+R+RDLG        D   NS  PR
Sbjct:   14 NAIAVAIDKDKNSQHVVRWAIDHLIINNPVIILVHVRHKNHQHHANNGNDVDSDEVQQLFVPFRGYCARKGVQLKEIILEDNDVARALLDYISKNFLGSIVVGASTRNAFT--RKFK-NQDVPSSLIKSTPDFCSVYVISKGKIASVRTAQRPANN--PPIPPKVPNMLALPGPTPHDHSDYYDDGIRFPYERSNDPMRGQ-------------LIRDRTRTP-SNLSMDSIDISFPGGAAPRISTSRVSTYEDHDFSSPFALGSIDISSQNPDFSLGSPKDLAASQAARDIEAEMRRLRVELKQTIDMYSTACREALTAKKKANELHQWKMEEARRFEEARHAEEAALAIAEMEKAKCKAAIEAAEKAQRLAKMEAQKRKYAELKAKREAEEKNRALTALAHNDVRYRKYTIEEIEDATEKFSQSNKIGEGGYGPVYKGTLDHTAVAIKVLRPDAAQGKKQFQQEVEVLSCIRHPHMVLLLGACPEYGCLVYEYMDNGSLEDRLLQRDNTPPISWRRRFKIAAEISTALLFLHQAKPEPLVHRDLKPANILLDRNYVSKISDVGLARLVPPSVADSVTQYHMTSAAGTFCYIDPEYQQTGMLTTRSDIYSLGILLLQIITAKPPMGLAHHVGKAIERGTFEKMLDPSVVDWPVEEALNFAKLALKCAELRKKDRPNLLTVIVPELSRIRDLGKN-----VDPLGNSDHPR 700          

Query:   34 PQNITMVAVDKDKNSAYAFRWAINHL--DNPVIVAVHVKHKNLPNLGTNVYPPDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNG-------NQSIPSKLPVQVGQHAEFETGIRSVLPRSSVTNEGSESRSFDS-ITATKGQTRERPRSAGSNLSMDKID--IPGGRGRHWASM-DERDMA---ALGPIDLD--------VPDSLGTPSASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLG--CTDNIVFTDTKNNSHS 2088
            P N T VA+DKDKNS +A RWAI+HL   NP+I+ +H++ K         Y   + ++  +F   R  C RK V +KE VIDD+DV K +L++  RN +++IV+GAS +N L   +KFK   DI   ++KSAPD+CSVYIISK KI S R+A R   N        +  IP ++P     H E +   R    R       +E  S++   T  +    +R RS+ S L++D I+  +PG R     S  DE D +   A+G +D+         VP S    SAS +S+DLEAEM+RL+ EL+QTM+MYS+ACK+A++AK +A+++               M++                                                 +R LTALA ND RYRKYT+EEIE AT+KFS + K+GEGGYGPVY+G LDHT VAIK+L P+A+QG++QFQQEVEVLS IRHPNMVLLLGACP++GCLVYE+M NGSLEDRL R+ N+  + W+KRF+I+AEIATALLFLHQ KPEP+VHRDLKP+NILLDRNYVSKISDVGLARLVP SV D+VTQY+MTSAAGTFCYIDPEYQQTG+LTTKSDIYS G+MLLQ+ITA+ PMGL HHV RA+EK  + E+LDPAVTDWP EAA SF+KLA+ C EL KKDRP+L TV++PELNRL+DLG     N  +   K   HS
Sbjct:   10 PPNSTAVAIDKDKNSPHAVRWAIDHLIISNPLIILLHIRQKYNHQNSNGGYVESDSEMQQLFTPFRGYCARKGVLLKEVVIDDNDVPKAILEYIGRNLLNNIVVGASTRNALA--RKFKGV-DISTTVMKSAPDFCSVYIISKGKILSVRTAQRPAANTATPPRQPSPGIPPQIP---SDHGELDDPFRGQGMRGIPRGLATERLSWEKGSTPIRAAAHDRHRSSPSTLALDTIESTLPGRRSTGRDSFSDESDYSGPLAMGSLDISSKNLDFSSVPVSPRVSSASQSSRDLEAEMRRLKLELRQTMEMYSTACKEALNAKKKAKELNQWKIEEAQRFEEARMAEETALAIAEMEKAKCRAAIEAAEKAQKLADAEAQRRKQAELKAKREAEEKNRALTALAHNDVRYRKYTIEEIEEATDKFSEAMKIGEGGYGPVYRGKLDHTPVAIKVLRPDAAQGKRQFQQEVEVLSSIRHPNMVLLLGACPDYGCLVYEYMHNGSLEDRLLRRGNTPVIPWRKRFKIAAEIATALLFLHQAKPEPLVHRDLKPANILLDRNYVSKISDVGLARLVPPSVADSVTQYHMTSAAGTFCYIDPEYQQTGMLTTKSDIYSFGIMLLQIITARSPMGLTHHVSRAIEKGTLAEMLDPAVTDWPAEAAESFSKLAIQCAELRKKDRPDLGTVIVPELNRLKDLGRKLESNKSYGYAKREGHS 714          

Query:   40 NITMVAVDKDKNSAYAFRWAINHLDNPVIVAVHVKHKNLPNLGTNVYPPDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGA-----SNKNHLTS----LKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNGNQSIPSKLPVQVGQHAEFETGIRSVLPRSSVTNEGSESRSFDSITATKGQTRERPRSAGSNLSMDKIDIPGGRGR-----HWASMDERDMA------ALGPIDLDVPDSLGTPSASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKNNSHSPRPP 2100
            N+ MVAV K KNS +AFRW  N++DNP+I+AVHVKHK  P+ GTNV+PPDE+D+A +F+ LR MC  K V +KEA+I D D+ +G+LD+A RN I +I++GA      N +   S     KKF+   D+  AI+KSAPDY SVY+ISK K+  +R A+  +G          P       + E    S L R   TN  S   S       K  +     +  +N S++ ID+     R     H +S++E   +      +L    L+   SL   S S    ++EAEMK LR +L+QTM MY SACK+AISA+N+A +I               MS+                                                 D+ L  LA+ D RYR+YT++EIE AT+ FS S K+GEGGYGPV+KG LDHT VAIK+L P+A+QGRKQF QEVEVL  IRHPNMVLLLGAC E+GCLVYE+MDNGSLEDRL RK N+ P+ W+KRF+I+ EIATALLFLHQTKPE IVHRDLKP+NILLD+N+VSKISDVGLARLVP SV D+VTQY+MT AAGT CYIDPEYQ TG LTTKSDIYSLG+M LQ+ITAKPPMGL+HHVKRA+E +   ++LDP VTDWPV+ AL+FAK++L C ELSKKDRP+LA  V+PELNRL+D GC       D +N  H+   P
Sbjct:   12 NLVMVAVGKHKNSGHAFRWTTNNIDNPIIIAVHVKHKGTPHQGTNVFPPDEKDIANVFSPLRQMCNEKVVKLKEAIIIDTDISRGILDYAKRNHIQTIIVGAPTGYKKNSSFKVSKHEDYKKFRGQDDLATAIMKSAPDYSSVYVISKDKVVESRPAIVPLGTVVAQSHGIAP------CKSENDKWSQLYRRGSTNSRSGRSSIHEFI--KSFSSNNNNNNHNNESLESIDLSSRSQRTPPLSHNSSLNENGSSGSNKFGSLNVAKLERNSSL--QSDSQLVGEMEAEMKELRLKLRQTMTMYKSACKEAISAQNKANEITQWKMEEERMVEEVIMSKEAALALAEKEKAKAKAAIKAADEAMRIAEKEAQRRMQVEKTAKKDIEERDQALNVLARKDIRYRQYTLDEIEKATQNFSLSMKIGEGGYGPVFKGQLDHTNVAIKILRPDANQGRKQFLQEVEVLCNIRHPNMVLLLGACQEYGCLVYEYMDNGSLEDRLLRKRNTPPIPWRKRFEIAYEIATALLFLHQTKPEAIVHRDLKPANILLDKNFVSKISDVGLARLVPPSVADSVTQYHMTEAAGTLCYIDPEYQNTGKLTTKSDIYSLGIMFLQIITAKPPMGLSHHVKRAIENENFFDMLDPDVTDWPVDEALAFAKISLRCAELSKKDRPDLALEVIPELNRLKDFGC-------DLQNYQHNQSHP 701          

Query:   34 PQNITMVAVDKDKNSAYAFRWAINHL--DNPVIVAVHVKHKNLPNLGTNVYP---PDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNGNQSIPSKLPVQVG-------QHAEFETGIRSVLPRSSVTNEGSESRSFDSITATKGQTR-ERPRSAGSNLSMDKIDIPGGRGRHWASMDERDMAA--------LGPIDLD--VPDSLGTPSASHTS-KDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLG 2040
            P N T+VA+DKDKNS YA RW I+HL  +NP I+ +HV+HK L + G N        E D   +F   R  C RKA+ +KE V+DD DV + ++D+  RN I +IV+GAS KN LT  +KF+ Y D+  +I KSAPD+CSVY+ISK K+ S RSA R + N   ++P KLP   G        + E E   R +       N GSE  +F+    T    R  R RSA +NLS+D ID+        +  D+ D +         L   D+D  +    G  S + TS K+L AEMKRL+ ELKQTMDMYS+ACK+AI+AK +A+++               +S+                                                  R LTALA ND RYRKY +EEIEVATEKFS + K+GEGGYGPVY+G LDHT VAIK+L P+A+QG +QFQQE+EVLSC+RHPNMVLLLGACPE+GCLVYE+M NGSLEDRL R+ ++  + W+ RF+I+AEIATALLFLHQ KPEP VHRDLKP+NILLDRNYVSKISDVGLARLVP SV D+VTQY+MTSAAGTFCYIDPEYQQTG+L TKSD+YS+G+MLLQ+ITAKPPMGL HHV+RA+EK    ++LD  V DWPVE AL+FA LAL C EL KKDRP+L +VVLPELNRL   G
Sbjct:   13 PINSTVVAIDKDKNSHYAVRWTIDHLLINNPQIILIHVRHKYLQHQGYNAGEGGGESETDAQQLFIAYRGYCARKAIQLKEIVLDDVDVSRAIIDYITRNRIKNIVVGASTKNALT--RKFRNY-DVSTSITKSAPDFCSVYVISKGKVVSVRSAQRPVVN--TAVPPKLPSPRGLPPQALPDNPELEDVAR-IQSLKGWRNVGSERVTFER---TNNNMRVPRARSAPTNLSIDNIDLQRPSTSRDSVSDDLDFSTPIRFASVDLSSQDMDFSITSDSGRDSLTPTSAKELAAEMKRLKLELKQTMDMYSTACKEAITAKQKAKELHQWRMEEARRFKEARLSEEAALAMAEMEKARCKAAIEAAEVAQKLAEKEAQRRRYAELKASREAEEKARALTALAHNDVRYRKYAIEEIEVATEKFSQAMKIGEGGYGPVYRGKLDHTPVAIKVLRPDAAQGMRQFQQEIEVLSCMRHPNMVLLLGACPEYGCLVYEYMSNGSLEDRLLRRGDTPSIPWRMRFKIAAEIATALLFLHQAKPEPFVHRDLKPANILLDRNYVSKISDVGLARLVPPSVADSVTQYHMTSAAGTFCYIDPEYQQTGMLGTKSDVYSMGIMLLQIITAKPPMGLTHHVRRAIEKGTFADMLDQTVPDWPVEEALAFANLALKCSELRKKDRPDLGSVVLPELNRLSGFG 696          

Query:   34 PQNITMVAVDKD-KNSAYAFRWAINHL----DNPVIVAVHVKHKNLPNLGTNVYPPDEE----DVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGASNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNG----NQSIPSKLPVQVG-QHAEFETGIRSVLPRSSVTNEGSESRSFDSITATKGQTRERPRSAGSNLSMDKIDIPGGRGRHWASMDERDMAA-----------LGPID-----LDVPDSLGTP--SASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLG 2040
            P N T VAVDKD KNS +A R+AI+HL     NP I+ +HV+HKN      + +  D E    D   +F    A C RK V +KE ++DDHDV K LL++ N + I++IV+GAS +N LT  +KFK+ +D+P +++K AP++CSVY+ISK K+   R+A R + N      Q  P  LP  +  +  E + G RS   + +V          + I       RER RSA  NLSMD IDIP   G    S+  R+  A            G +D     LD   +  +P  S+  +++D+EAEMKRL+ ELKQTMDMYSSACK+AISAKN+A+++                ++                                                 +R L ALA ND RYRKYT+EEIE AT++FS S K+GEGGYGPVYKG LDHT VAIK+L P+A+QGRKQFQQEVEVLSCIR+PNMVLLLGACPE GCLVYE+MDNGSLED LFR+ N+ P++W++RF+I+AEI+T LLFLHQ KPEP+VHRDLKP+NIL+DRNYVSKISDVGLARLVP S+ D VTQY+MT+AAGTFCYIDPEYQQ+G+LTTKSDIYSLG++LLQ+ITAKP MGL+HHV+R++EK    E+LDPAV DWP+E AL+FA+LAL C EL K+DRP+L TVV+PELNRLRD G
Sbjct:   13 PINATAVAVDKDNKNSNHAVRFAIDHLVANNTNPYIILIHVRHKN-----HHPHQSDGESGNHDGHHVFVPYSAYCARKEVQVKEVILDDHDVAKALLEYINNHYINNIVVGASTRNALT--RKFKIGYDVPTSLVKLAPEFCSVYVISKGKMVVGRTAKRPVVNTATPPKQPSPQGLPPCIPTEQTEADNGARS-RGQPAVRGGWKNGGGSEKIPVV----RERTRSAPVNLSMD-IDIPNP-GSSRCSLSSRNSNADENEFPGMFNSFGSVDIISQGLDFSSASCSPKESSRQSARDIEAEMKRLKLELKQTMDMYSSACKEAISAKNKAKELNQWKQEEARKFEEARHAEEAALAIAEMEKAKCKAAIEAAEASQRVAEMEAQRRRQAEMKAKKEAQEKNRALNALAHNDVRYRKYTIEEIEQATQEFSASNKIGEGGYGPVYKGKLDHTPVAIKVLRPDAAQGRKQFQQEVEVLSCIRYPNMVLLLGACPEFGCLVYEYMDNGSLEDLLFRRGNTPPISWRRRFKIAAEISTTLLFLHQAKPEPLVHRDLKPANILIDRNYVSKISDVGLARLVPPSMADEVTQYHMTAAAGTFCYIDPEYQQSGMLTTKSDIYSLGIVLLQIITAKPAMGLSHHVRRSIEKGTFSEMLDPAVPDWPIELALAFAQLALQCAELRKRDRPDLGTVVVPELNRLRDFG 699          

Query:   34 PQNITMVAVDKDKNSAYAFRWAINHL----DNPVIVAVHVKHKNLPNLGTNVYPPDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGA--SNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNGNQSIPSKLPVQVGQHAEFETGIRSVLPRSSVTNEGSESRSFDSITATKGQTRERPRSAGS---NLSMDKIDIPGGR---GRHWASMDERDMAAL--GPIDLDVP--DSLGTP-----SASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKNNSHSPRPP 2100
            P N T+VA+DKDKNS YA RWA +HL    +NP ++ VHV+ KN  N G       ++++  +F   R  C RK ++M E +++D DV + +LD+ N N +++IV+G+  S+KN      KF   HD+ A+I+KS P++CS+Y+ISK K+ S+R+A R + N    +P + P             +  LPR    +  +    + +        RER RSA +   + + D     G R   GR+  S DE D  +L  G +DL     D +G       SAS +++D+EAEMKRL+ EL+QTMDMYSSACK+A++AK  A ++                ++                                                 DR LTAL QND RYRKY++EEIE AT++F+ + K+GEGGYGPVYKG LDHT VAIK+L P+A+QG+KQFQQEVEVLSCIRHP+MVLLLGACPE+GCLVYEFM+NGSLEDRLFR+ NS PL+W+KRFQI+AEIATAL FLHQTKPEP+VHRDLKP+NILLDRNYVSKISDVGLARLVP+SV +NVTQY+MTSAAGTFCYIDPEYQQTG LTTKSDIYSLG+MLLQ+ITAK PMGLAHHV RA+EK    ++LDP VTDWPVE A++FAKL L C EL K+DRP+L   ++PEL RLR+LG  +    +     S+S   P
Sbjct:  517 PANSTVVAIDKDKNSHYAVRWAADHLFNMINNPNMILVHVRLKN-SNHG-------DDELNHLFVPYRGYCARKGISMMEVILEDSDVARAILDYVNNNLVNNIVVGSASSSKNPFARSLKFTKSHDVAASILKSTPEFCSIYVISKGKVQSSRAAQRRITN--TLVPPREPSSAFHLQNLPDPDQDPLPRGQRNSRNTTPERYHNDNGFNAM-RERRRSAANGSLDFNYDFKQANGQRNPVGRNSFS-DESDGGSLMMGSVDLSAQNYDFIGASGSSDESASQSTRDIEAEMKRLKLELRQTMDMYSSACKEALNAKKTANELNMWKKEEARRFEEARSAEEAALAVAEMEKAKCKAAMEAAEKAQRMADLEGQRRKQAEMKARRESQEKDRALTALGQNDVRYRKYSIEEIEEATDRFASNMKVGEGGYGPVYKGTLDHTPVAIKVLRPDAAQGKKQFQQEVEVLSCIRHPHMVLLLGACPEYGCLVYEFMENGSLEDRLFRRGNSPPLSWRKRFQIAAEIATALSFLHQTKPEPLVHRDLKPANILLDRNYVSKISDVGLARLVPASVANNVTQYHMTSAAGTFCYIDPEYQQTGKLTTKSDIYSLGIMLLQIITAKNPMGLAHHVARAIEKGTFKDMLDPVVTDWPVEEAINFAKLCLKCSELRKRDRPDLGKDIVPELVRLRNLGLDNESDASHIMGKSNSKEKP 1214          

Query:   34 PQNITMVAVDKDKNSAYAFRWAINHL----DNPVIVAVHVKHKNLPNLGTNVYPPDEEDVALIFNNLRAMCQRKAVTMKEAVIDDHDVVKGLLDFANRNSIHSIVIGA--SNKNHLTSLKKFKVYHDIPAAIIKSAPDYCSVYIISKLKIASARSAVRSMGNGNQSIPSKLPVQVGQHAEFETGIRSVLPRSSVTNEGSESRSFDSITATKGQTRERPRSAGS---NLSMDKIDIPGGR---GRHWASMDERDMAAL--GPIDLDVP--DSLGTP-----SASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLG 2040
            P N T+VA+DKDKNS YA RWA +HL    +NP ++ VHV+ KN  N G       ++++  +F   R  C RK ++M E +++D DV + +LD+ N N +++IV+G+  S+KN      KF   HD+ A+I+KS P++CS+Y+ISK K+ S+R+A R + N    +P + P             +  LPR    +  +    + +        RER RSA +   + + D     G R   GR+  S DE D  +L  G +DL     D +G       SAS +++D+EAEMKRL+ EL+QTMDMYSSACK+A++AK  A ++                ++                                                 DR LTAL QND RYRKY++EEIE AT++F+ + K+GEGGYGPVYKG LDHT VAIK+L P+A+QG+KQFQQEVEVLSCIRHP+MVLLLGACPE+GCLVYEFM+NGSLEDRLFR+ NS PL+W+KRFQI+AEIATAL FLHQTKPEP+VHRDLKP+NILLDRNYVSKISDVGLARLVP+SV +NVTQY+MTSAAGTFCYIDPEYQQTG LTTKSDIYSLG+MLLQ+ITAK PMGLAHHV RA+EK    ++LDP VTDWPVE A++FAKL L C EL K+DRP+L   ++PEL RLR+LG
Sbjct:   12 PANSTVVAIDKDKNSHYAVRWAADHLFNMINNPNMILVHVRLKN-SNHG-------DDELNHLFVPYRGYCARKGISMMEVILEDSDVARAILDYVNNNLVNNIVVGSASSSKNPFARSLKFTKSHDVAASILKSTPEFCSIYVISKGKVQSSRAAQRRITN--TLVPPREPSSAFHLQNLPDPDQDPLPRGQRNSRNTTPERYHNDNGFNAM-RERRRSAANGSLDFNYDFKQANGQRNPVGRNSFS-DESDGGSLMMGSVDLSAQNYDFIGASGSSDESASQSTRDIEAEMKRLKLELRQTMDMYSSACKEALNAKKTANELNMWKKEEARRFEEARSAEEAALAVAEMEKAKCKAAMEAAEKAQRMAELEGQRRKQAEMKARRESQEKDRALTALGQNDVRYRKYSIEEIEEATDRFASNMKVGEGGYGPVYKGTLDHTPVAIKVLRPDAAQGKKQFQQEVEVLSCIRHPHMVLLLGACPEYGCLVYEFMENGSLEDRLFRRGNSPPLSWRKRFQIAAEIATALSFLHQTKPEPLVHRDLKPANILLDRNYVSKISDVGLARLVPASVANNVTQYHMTSAAGTFCYIDPEYQQTGKLTTKSDIYSLGIMLLQIITAKNPMGLAHHVSRAIEKGTFKDMLDPVVTDWPVEEAINFAKLCLKCSELRKRDRPDLGKDIVPELVRLRNLG 689          

Query: 1147 RVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRL 2028
            +V+  L   D+RYRKYT+EEI  ATE FSP K +GEGGYG VY+  LD T  A+K++  +  + +++F +EVEVLS +RHP++VLLLGACPE+GCLVYE+++NGSLE+ +F + N  PL W  RF++  E+A  L FLH +KPEPIVHRDLKP NILL+RNYVSKI+DVGLA+LV     DNVT Y  +  AGT  YIDPEY +TG +  KSD+Y+ G+++LQ++TA+ P G+   V+ AV+K  + E+LD +VTDWP+      A++ L C E   +DRP+L + V+P L RL
Sbjct:  415 KVIDQLLGTDHRYRKYTIEEIVTATEGFSPEKVIGEGGYGKVYQCSLDSTPAAVKVVRLDTPEKKQEFLKEVEVLSQLRHPHVVLLLGACPENGCLVYEYLENGSLEEYIFHRKNKPPLPWFIRFRVIFEVACGLAFLHSSKPEPIVHRDLKPGNILLNRNYVSKIADVGLAKLVTDVAPDNVTMYRNSVLAGTLHYIDPEYHRTGTIRPKSDLYAFGIIILQLLTARNPSGIVPAVENAVKKGTLTEMLDKSVTDWPLAETEELARIGLKCAEFRCRDRPDLKSEVIPVLKRL 708          

Query: 1180 RYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVP-SSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVE-KDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLG 2040
            +Y+ +  EEI  AT  FS   K+G G YG VYK +L HT   +K+L    +Q  KQFQQE+E+LS IRHP++VLLLGACPE G LVYE+M+NGSLEDRLF+ NNS PL W +RF+I+ E+A AL+FLH++KP+PI+HRDLKP+NILLD N+VSK+ DVGL+ +V    +    T Y  TS  GT CYIDPEYQ+TG +++KSDIYS G++LLQ++TAKP + L H V+ A++  D  ++ILD    +WP+E     A LAL C EL  KDRP+L   +LP L  L+ + 
Sbjct:  464 QYQHFAWEEIMAATSSFSEELKIGMGAYGAVYKCNLHHTTAVVKVLQSAENQLSKQFQQELEILSKIRHPHLVLLLGACPEQGALVYEYMENGSLEDRLFQVNNSPPLPWFERFRIAWEVAAALVFLHKSKPKPIIHRDLKPANILLDHNFVSKVGDVGLSTMVQVDPLSTKFTIYKQTSPVGTLCYIDPEYQRTGRISSKSDIYSFGMILLQLLTAKPAIALTHFVESAMDSNDEFLKILDQKAGNWPIEETRELAALALCCTELRGKDRPDLKDQILPALENLKKVA 752          

Query:  799 LGTPSASHTSKDLEAEMKRLRRELKQTMDMYSSACKQAISAKNQAEQIXXXXXXXXXXXXXXXMSQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDRVLTALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKD-RIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLG 2040
            L   S +    +L  E+++LR ELK   +MY+ A  + + A  +  ++ + + EE  K+ E++  +E A   A +EK R + AM+ AE  K    +EA  RREAE KA ++A E+D++  +L     +Y+ YT EEI  AT  F+ + K+G G YG VYK +L HT  A+K+L+   +Q  KQF QE+E+LS IRHP++VLLLGACPE GCLVYE+MDNGSL+DRL   N++ P+ W +RF+I+ E+A+AL+FLH++KP PI+HRDLKP NILLD N+VSK+ DVGL+ +V    V + T +  TS  GT CYIDPEYQ+TGI++ KSD+YSLGV++LQ+ITAKP + + H V+ A+  D   + ILD     WP+      A L L C E+ ++DRP+L   ++P L RLR + 
Sbjct:  347 LSVHSITDNQVNLNFEIEKLRAELKHVQEMYAMAQTETVGASKKLTELNQRRFEESEKLVELKEKEEVAKDTASKEKQRYEEAMKEAEKVKELMMKEALHRREAEFKAERDAREKDKLQASLVSPGVQYQHYTWEEIAAATSDFAENLKIGIGAYGSVYKCNLHHTTGAVKVLHAGETQLSKQFDQELEILSKIRHPHLVLLLGACPERGCLVYEYMDNGSLDDRLMLVNDTPPIPWFERFRIALEVASALVFLHKSKPRPIIHRDLKPGNILLDHNFVSKLGDVGLSTMVNQDDVSSRTIFKQTSPVGTLCYIDPEYQRTGIISPKSDVYSLGVVILQLITAKPAIAITHMVEEAIGDDAEFMAILDKKAGSWPISDTRELAALGLCCTEMRRRDRPDLKDQIIPALERLRKVA 761          

Query: 1180 RYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSS--VVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEK---DRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKNNSHSPRPPMP 2106
            +Y+++T EEI  AT  FS   K+G G YG VYK +L HT  A+K+L+   S   KQF QE+E+LS IRHP++VLLLGACP+HG LVYE+M+NGSLEDRLF+ N+S+P+ W  R +I+ E+A+AL+FLH++KP PI+HRDLKP+NILL+ N+VSK+ DVGL+ ++ ++  +    T Y  TS  GT CYIDPEYQ+TG ++ KSD+Y+ G+++LQ++T +  M L + V+ A+E    D +++ILD    +WP+E     A LAL C EL  KDRP+L   +LP L  L+ +         D   NS S  P  P
Sbjct:  444 QYQEFTWEEIINATSSFSEDLKIGMGAYGDVYKCNLHHTIAAVKVLHSAESSLSKQFDQELEILSKIRHPHLVLLLGACPDHGALVYEYMENGSLEDRLFQVNDSQPIPWFVRLRIAWEVASALVFLHKSKPTPIIHRDLKPANILLNHNFVSKVGDVGLSTMIQAADPLSTKFTMYKQTSPVGTLCYIDPEYQRTGRISPKSDVYAFGMIILQLLTGQQAMALTYTVETAMENNNDDELIQILDEKAGNWPIEETRQLAALALQCTELRSKDRPDLEDQILPVLESLKKVA--------DKARNSLSAAPSQP 749          

Query: 1180 RYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKN------NSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAV--EKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRDLGCTDNIVFTDTKNNSHSPRP 2097
            +Y K+  EEI  AT  FS   K+G GGYG VY+ +L HT VA+K+L+ + S   KQF QE+E+LS IRHP+++LLLGACPE G LVYE+M NGSLE+RL ++          PL W +RF+I+ EIA+AL FLH  +P PIVHRDLKP+NILLDRN VSKI DVGL+++V        T +  T   GTF YIDPEYQ+TG++T +SDIY+ G++LLQ++TA+  MGLAH +++A+  +  +  EILD    DWPV+ A     + L C E+ K+DRP+L   +LP L RL+++      +F D   + H   P
Sbjct:  413 QYMKFEWEEIVEATSSFSDELKIGVGGYGSVYRCNLHHTTVAVKVLHSDKSSLTKQFHQELEILSKIRHPHLLLLLGACPERGSLVYEYMHNGSLEERLMKRRPNVDTPQPPPLRWFERFRIAWEIASALYFLHTNEPRPIVHRDLKPANILLDRNNVSKIGDVGLSKMVNLDPSHASTVFNETGPVGTFFYIDPEYQRTGVVTPESDIYAFGIILLQLVTARSAMGLAHSIEKALRDQTGKFTEILDKTAGDWPVKEAKEMVMIGLRCAEMRKRDRPDLGKEILPVLERLKEVASIARNMFADNLIDHHHNAP 726          

Query: 1189 KYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLRD 2034
            +++  E+E ATE FS S K+GEGG+G VYKG L +  VAIK+L P++ QG+ QF+QEV +LS +RHP++V LLGAC E   LVYEF+ NGSLED L   +  + LTWQ R +I AEI +AL+FLH+ KP P+VH DLKP+NILL  N VSK+SD G++RL+  S  +N T Y      GT  Y+DPE+  TG LT +SD+YS G+++L+++T KPP+G+ + V+ A+EK  +  ++D +V +WP       A LAL C ELS++ RP+L+  V   +  +RD
Sbjct:  432 EFSSSEVESATENFSNSLKIGEGGFGCVYKGILRNMTVAIKVLRPDSLQGQSQFEQEVSILSRVRHPHLVTLLGACSESSTLVYEFLPNGSLEDFLMCSDKRQTLTWQARIRIIAEICSALIFLHKNKPHPVVHGDLKPANILLGVNLVSKLSDFGISRLLIQSSTNNTTLYRTMHPVGTPLYMDPEFLSTGELTPQSDVYSFGIVVLRLLTGKPPVGIKNIVEDAMEKGDLNSVIDTSVGEWPHLHIEQLAYLALRCTELSRRCRPDLSGEVWAIVEAIRD 713          

Query: 1156 TALAQNDNRYRKYTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLR 2031
            T+  Q    +  ++  EIE AT  F  + K+GEGGYG +Y G L HT VAIK+LNP +SQG  ++QQEV+VLS +RHPN++ L+GACPE   LVYE++  GSLEDRL  K+NS PL+WQ R +I+ EI  AL+FLH  K   +VH DLKP+NILLD N VSK+SD G   L+      N ++   T   GT  Y+DPE   +G LT KSD+YS G++LL+++T +P + +++ VK A++   + ++LDP   DWP   A   A+LAL C E   ++RP+L T V   L  +R
Sbjct:  457 TSTLQLPQYFTDFSFSEIEEATNHFDSTLKIGEGGYGSIYVGLLRHTQVAIKMLNPNSSQGPVEYQQEVDVLSKMRHPNIITLIGACPEGWSLVYEYLPGGSLEDRLTCKDNSPPLSWQNRVRIATEICAALVFLHSNKAHSLVHGDLKPANILLDSNLVSKLSDFGTCSLLHP----NGSKSVRTDVTGTVAYLDPEASSSGELTPKSDVYSFGIILLRLLTGRPALRISNEVKYALDNGTLNDLLDPLAGDWPFVQAEQLARLALRCCETVSENRPDLGTEVWRVLEPMR 744          

Query: 1192 YTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNLATVVLPELNRLR 2031
            Y+  EI  AT +F PS KLGEG YG VYKG+L H  VA+K+L    S    +F++ VE+LS +RHPN+V L+GACPE   L+Y+++ NGSLED    +NN   L+W+ R +I++EI +ALLFLH   P  I+H +LKPS ILLD N V+KI+D G+++L+P   +D               ++DP Y  +  +T +SDIY+ G++LLQ++T +P  G+   VK A+E D I  +LD +  DWPV      A +A+ C + +  +RP+LA VVL  ++R++
Sbjct:  448 YSFMEINEATNEFDPSWKLGEGKYGSVYKGNLQHLQVAVKMLPSYGSLNHFEFERRVEILSRVRHPNLVTLMGACPESRSLIYQYIPNGSLEDCFSSENNVPALSWESRIRIASEICSALLFLHSNIP-CIIHGNLKPSKILLDSNLVTKINDYGISQLIPIDGLDKSDP-----------HVDPHYFVSREMTLESDIYAFGIILLQLLTRRPVSGILRDVKCALENDNISAVLDNSAGDWPVARGKKLANVAIRCCKKNPMNRPDLA-VVLRFIDRMK 714          

Query: 1192 YTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHTAVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPEHGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLV--PSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVEILDPAVTDWPVEAALSFAKLALGCVELSKKDRPNL---ATVVLPELNR 2025
            ++ +++E ATE F  ++++G+  YG  YKG + +  V IKL     S  +K FQQEV +L   RHPN++  +G C E   LVYE++ NG+LEDR+   NNS PL+W  R QI  EI  ALLFLH  K   +VH DL+P NIL+D NY SKI + G++ L     +   N+T            Y+DPE+  TG LTT SD+YSLGV++L+++T  PP+ L+  V  A+  D +  ++D +  DWP   A   A + L C  +++K RP+L     +V+  L R
Sbjct:  147 FSRKDMEQATEHFKNAREVGDTEYGHTYKGMIHNMKVLIKL-----SSSQKLFQQEVSILRQWRHPNIITFIGVCSEVSALVYEWLPNGNLEDRIICTNNSAPLSWYNRTQIIGEICCALLFLHSNKSTALVHGDLRPCNILIDANYRSKICNFGMSNLFLQLGTFPPNLT--------ARLPYMDPEFNTTGELTTLSDVYSLGVIILRLLTGMPPLTLSEKVAEALGSDSLHLLIDKSAGDWPYIEAKQLALIGLSCTGMTRKKRPDLLNEVWIVIEPLTR 416          

Query: 1192 YTMEEIEVATEKFSPSKKLGEGGYGPVYKGHLDHT--------AVAIKLLNPEASQGRKQFQQEVEVLSCIRHPNMVLLLGACPE--HGCLVYEFMDNGSLEDRLFRKNNSRPLTWQKRFQISAEIATALLFLHQTKPEPIVHRDLKPSNILLDRNYVSKISDVGLARLVPSSVVDNVTQYYMTSAAGTFCYIDPEYQQTGILTTKSDIYSLGVMLLQVITAKPPMGLAHHVKRAVEKDRIVE--------------ILDPAVTDWPVE-AALSFAKLALGCVELSKKDRPNLATVV 2007
            +T  E+ V T+ FS S  LGEGG+GPV+KG +D           VA+KLL+ +  QG ++F  EV  L  ++HPN+V L+G C E  H  LVYEFM  GSLE +LFR+  S PL W  R  I+ E A  L FLH+ + +PI++RD K SNILLD +Y +K+SD GLA+  P     +V+    T   GT  Y  PEY  TG LT KSD+YS GV+LL+++T +  + +A    R+  K+ +VE              I+DP + D   E  A   A LA  C+    K RP+++TVV
Sbjct:   64 FTQAELRVITQSFSSSNFLGEGGFGPVHKGFIDDKLRPGLKAQPVAVKLLDLDGLQGHREFMTEVMCLGKLKHPNLVKLIGYCCEEAHRLLVYEFMPRGSLESQLFRRC-SLPLPWTTRLNIAYEAAKGLQFLHEAE-KPIIYRDFKASNILLDSDYTAKLSDFGLAKDGPQGDDTHVS----TRVMGTQGYAAPEYIMTGHLTAKSDVYSFGVVLLELLTGRKSVDIA----RSSRKETLVEWARPMLNDARKLGRIMDPRLEDQYSETGARKAATLAYQCLRYRPKTRPDISTVV 350